Hypothalamic Inflammation

Table 2 shows some of the chemical mediators involved in Mr X’s inflammatory process, causing it to become more severe and uncontrolled, resulting in a further decline in his clinical presentation.

Hypothyroidism can affect the body temperature because it slows down the metabolism. This causes the energy produced to be less. With that

The thermoregulatory centre is the part of the brain that monitors and controls body temperature. The pancreas meanwhile monitors and controls blood glucose concentration. It produces a hormone called insulin that reduces blood glucose levels.( Diabetes is a disease which can be caused by insufficient insulin.)

Body temperature is maintained within a fairly regular range by the hypothalamus that is found in the brain. The hypothalamus

8. Thermoregulation is to regulate temperature. The hypothalamus sends signals to the blood vessels, muscles, and/or sweat glands to alter the temperature of the human body when needed. You should always keep your body at a steady temperature.

The hypothalamus is the part of the brain notified by receptors of an occurring imbalance in the body temperature and triggers reactions to overcome or counteract the change.

While a natural response to pain and injury, inflammation is also related to some debilitating conditions and diseases. The tame end of symptoms include headaches, weight gain, and joint pain. But heart disease, Crohn’s disease, and even some types of cancer are also related to chronic inflammation. And chronic inflammation wasn't something treatable fifty years ago, before the advent of Systemic Enzyme Therapy. Now there is Heal N Soothe.

Eagleton (2012) explains the pathological process inflammation has in weakening the arterial wall through the release of cellular and cytokine messengers which initiate various actions

There are some grades of systematic inflammation process related to some pathological conditions such as cardiovascular disease and type 2 diabetes.

Inflammation is the primary response of the lung immune system to infection or irritation like an occult foreign body. Activated

What is Inflammation? There are two types of inflammation, acute inflammation and chronic inflammation. Acute inflammation is a good inflammation, it helps the body heal after the immune cells and nutrients destroy the bacteria and repair the damage tissue. Chronic inflammation is the bad inflammation, it comes when the body is not able to heal itself properly. It is also brought on by our immune system being overstressed or over exposure to the unhealed wound. A lot of foods like white bread, French fries, red meat and margarine are another

In recent years, the healthcare industry has seen a significant shift with a lot of new innovations and a number of target studies done on various topics. In particular, there has been an increased focus on understanding the inflammation and its role & relationship to chronic diseases. In this post, we are going to understand the inflammation and its role in general health & chronic diseases in little more detail.

The systemic response results in a variety of pathophysiolocigal changes aimed at repairing the injury (Whicher and Westacott, 1992), and it is accompanied by the hepatic synthesis and release of several plasma proteins, known as acute phase proteins (APP) (Baumann and Gauldie, 1990), which initiate the anti-inflammatory process through a wide range of biological functions. The pattern of responding APP varies between animal species, and they are classified as major, moderate, minor and negative APP based on their increase in plasma (Murata et al., 2004). Positive associations have been established between circulating concentrations of specific APP and the extent of particular disorders in different species, which support their potential use as health markers in animals. Nevertheless, they act as non-specific markers, as they do not clarify the etiology of disease (Petersen et al., 2004) but are able to disclose the presence of inflammatory lesions, whether they are primary or secondary to other disorders (Eckersall, 1995).

Studies have revealed that the P2X7 receptor may hold some of these answers (Ferrari et al. 1997), (Perregaux and Gabel, 1998). P2X7 is said to be a key mediator in the activation and secretion of the interleukin-1 family of cytokines. Perhaps the two most well established are the mechanisms involved with the maturation and release of IL-1β and IL-18. Muñoz-Planillo et al. (2013) suggests that rapid K+ efflux acts as a co-signal alongside activation of toll-like receptors via pathogen-associated molecular patterns (PAMPs). These two signals combined are said to initiate the assembly of the NLRP3 inflammasome. Whilst the signal received through toll-like receptors is responsible for the synthesis of inflammasome components and inactive forms of IL-1β and IL-18, the second signal received through rapid K+ efflux influences the assembly of the inflammasome itself leading to the activation of caspase-1. Caspase-1 processes and activates pro-IL-1β and pro-IL-18

“Inflammation is a nonspecific, defensive response of the body to tissue damage” says J.Tortora & Derrickson (2011), it is an effort