preview

Ic50 Unit 1 Lab Report

Satisfactory Essays
A1805 Description: IC50: 0.6 μM, 0.1 μM and 0.1 for μM v-Abl, c-Kit and PDGFR, respectively. Imatinib is a Abl/c-kit/PDGFR inhibitor. Abl is a proto-oncogene related with chronic myelogenous leukemia. c-kit is a protein on the surface of various types of cells. PDGFR is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. In vitro: The H727 and BON-1 carcinoid cell lines had been used for the in vitro studies. A cytotoxic effect of imatinib on both H727 and BON-1 carcinoid cells was observed in the dose –dependent manner [1]. In vivo: In mice, imatinib inhibited the growth of primary murine lung fibroblasts and the PDGFR-beta autophosphorylation. Administration of imatinib also prevented bleomycin-induced
Get Access