Identification Of A Nuclear Receptor For Bile Acids

Discuss what you did in this lab and what you will cover in the lab

The content of this section depends to a large extend on the nature of the experiment. Topics here should include a section labelled:

The vials were placed in the water and the oxygen levels were read every 5 minutes until 30 minutes was reached. As the oxygen levels were collected they were put into a table that had all three tubes labeled at each 5-minute increment. After 30 minutes the experiment was completed and the clean up process could begin.

Review each scenario below, and choose one to complete for your assignment. Each scenario contains specific questions that will ask you to provide examples, explain your suggestions for improvement, and refer to the lesson. Be sure to respond to each question in complete sentences.

This document is not meant to be a substitute for a formal laboratory report. The Lab Report Assistant is simply a summary of the experiment’s questions, diagrams if needed, and data tables that should be addressed in a formal lab report. The intent is to facilitate students’ writing of lab reports by providing this information in an editable file which can be sent to an instructor.

including the main method used to accomplish the purpose. Ex: The purpose of the experiment

This document is not meant to be a substitute for a formal laboratory report. The Lab Report Assistant is simply a summary of the experiment’s questions, diagrams if needed, and data tables that should be addressed in a formal lab report. The intent is to facilitate students’ writing of lab reports by providing this information in an editable file which can be sent to an instructor.

The liver X receptors (LXRs) are identified as orphan members of the nuclear receptor superfamily. Like other receptors in the family, LXRs heterodimerize with RXR and bind to specific response elements. LXRα and β are nuclear receptors regulating the metabolism of several important lipids, such as cholesterol and bile acids.

About OCA – up for debate about how science-y we want to get here OCA is an agonist of the farnesoid X receptor (FXR), a nuclear receptor expressed in the liver and intestine and a key regulator of bile acid, inflammatory, fibrotic and metabolic pathways.

Fatty acids, monoglycerols, cholesterol, and apoprotein are packaged up to form cholymircons. Before the cholymicrons can move into the blood, they are transported through the lymphatics system. The cholymicrons are then transported through the blood which provide deliver lipids, and triglycerides to the tissues that need it for energy. The remaining cholymicrons will finish at the liver where they bind to LDL receptors which will allow for them to enter into the hepatic cells. In the liver, triglycerides can be formed and packaged into lipoproteins. Horowittz (2003) reported in the review article, that most fatty intra-abdominal adipose tissue contains the greatest lipolytic activity. Most of the fatty acids that are released from the intra-abdominal

1. Lab reports are to be computer-generated and double-spaced. All sections of the report must

Welch et al.4 analysed MRP4 and BSEP inhibition data of previously generated data5 in order to illustrate compounds in the dataset that inhibit only MRP4, BSEP or both transporters simultaneously and correlate the inhibition info to the DILI data for this compounds. The analysis of the data demonstrated that most of the BSEP inhibitors were also MRP4 inhibitors and that most of the cholestatic compounds were inhibiting both BSEP and MRP4 or only MRP4. Finally, only one of the cholestatic compounds was identified to inhibit only BSEP4. For one more time the fact that the MRP4 inhibition itself without the inhibition of BSEP is capable of resulting to DILI is difficult to rationalise based upon a two transporter system as investigated in this work. Because as it has been highlighted before MRP4 is hypothesised to act as a backup mechanism and not as the main efflux mechanism of bile acids. The paper in this instance is lacking of sufficient explanation in this

This substance is produced when a human digests lipids or fats. According to Sareen Gropper and Jack Smith’s “Advanced Nutrition and Human Metabolism” bile is produced through the process of chemically altering cholesterol, which is a type of fat found in a human’s blood. This process takes place in the liver and bile acids are produced. These bile acids are then conjugated or united with taurine and glycine to produce biosurfactants known as bile salts. The existence of bile salts inside of bile gives the substance the capacity to amalgamate lipids and fats with their aqueous (watery) environment inside of the gallbladder. According to Sareen Gropper and Jack Smith’s “Advanced Nutrition and Human Metabolism” bile is released from its origin (gallbladder) into the small intestine. Through the process of emulsification the bile substance in the small intestine disintegrates fats into much tinier particles which can be digested and absorbed at a much more efficient and quicker rate. This evidently shows that without bile and in turn bile salts the digestion of fats will not be

Describe the lab that you designed to investigate the problem and explain how the lab/methodology helped in your investigation.

Make An Investigatory Project Sample Format: # Abstract After finishing the research and experimentation, you are required to write a (maximum) 250-word...