Emily Davis
Partner: None
Chemistry 253- TA: Alma Wellensiek
Lab 3: Identifying a Constituent of “Panacetin”
9/15/2011
Purpose: The purpose of this experiment is to determine the unknown component of Panacetin.
Theory: Panacetin is an analgesic (pain reducing) and antipyretic (fever reducing) drug that is sold in drug stores. However, there is a suspicion that this bottle may be counterfeit, not containing the chemicals that it should. Panacetin should be made up of about 50 percent of the unknown component that we previously separated out of Panacetin for testing. We suspect that this unknown compound is either acetanilide or phenacetin, both of which can be toxic to humans. It is very important that this component is
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These were most likely impurities, in which case I added a bit more water than was necessary. Also, the lab manual says to take two samples of each mixture (unknown; ½ phenacetin; ½ acetanilide) for the melting point, but we only conducted one. There were a few safety concerns in this lab. Both phenacetin and acetanilide are known to be mild irritants, thus contact with skin and eyes should be avoided or minimized around the unknown. Another issue to keep in mind is that we will be moving glass from hot to cold surfaces, which can cause the glass to crack or break. Extra care should be taken when lowering the temperature of a beaker to avoid this issue.
Observations/ Results: When boiling the water before placing it in the unknown, my water never actually came to a boil. It was steaming very heavily and I was losing a considerable amount of water, especially from my smaller beaker, so I had to just assume that it was hot enough. This may have affected the amount of material that I got to dissolve. Either way, the fact that it took 51mL was a good indicator that my unknown was phenacetin, due to phenacetin having a much lower solubility than acetanilide. I also noticed that even though I had put in more hot water than phenacetin should have needed to dissolve (45.9mL), white flakes still remained in the beaker. I assumed these to be impurities. Observations/
The purpose of this lab is to investigate the composition of a compound suspected to be Panacetin, a type of pain-killer. Panacetin is typically made up of sucrose, aspirin, and acetaminophen, but the third component in this experiment is unknown. The unknown component is suspected to be a chemical relative of acetaminophen, either acetanilide or phenacetin. Using techniques such as extraction, evaporation, and filtration, the three components will be isolated based on their solubilities and acid-base properties. Then, the percent composition of Panacetin can be deduced based on the masses of the three dried components. The
Product bubbled upon addition to the hydrochloric acid; liquid turned cloudy ¡V precipitate was present; zinc sample disintegrated slowly and turned black in color.
Oxycontin is the brand name for an opioid analgesic containing the active ingredient oxycodone hydrochloride. Correspondingly, oxycodone is an opiate or a class of drugs derived from the opium poppy. Oxycodone-containing products come in an assortment of forms. The forms often include tablets, capsules, and liquid forms. However, oxycontin is mainly in the formation of white round tablets that have an “OC” on one side and the number 10 or another integer on the flipside. The “OC” stands for Oxycontin/Oxycodone and the digits on the back represent the amount of oxycodone (in milligrams) that the drug carries. Oxycodone was initially prescribed to medicate the chronic pain that patients with terminally ill cancer faced. In such cases, oxycontin works by changing the way the brain and nervous system respond to pain. In spite of it’s benefits, when abused, Oxycontin becomes dangerous. A toxic overdose and/or death can occur by taking the tablet broken, chewed, or crushed. With this drug, addiction and death are two
In part 1, the mass of maleic anhydride weighed was about 8.06 grams. When the maleic anhydride was added to the boiling water and it began to dissolve almost instantly. Although the solution was taken off of the bunsen burner, it kept on bubbling. Before the solution began to cool down it was clear and odourless. Once the solution began to cool down in the ice, it began to precipitate and it also began to turn white/foggy. After cooling, the precipitate weighed about 1.45 grams. In part 2, the filtrate was boiled using refluxing equipment. The solution at first was slightly yellow and this could be a source of error, it was also odourless. Secondly, at around 8 minutes of boiling the solution was turning white/foggy and a precipitate was beginning
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The tables above display the melting point range of each of the chemicals tested. Table 1 represents the results found in part 1 of the lab. It was found that the 50-50 mix has the lowest melting point. This is likely because the less pure a compound is, the lower its melting point will be. The 50-50 mix is the least pure of the 3 compounds so therefore the melting point was lower. In Part two of the lab it was found that the melting point range of the unknown compound (shown in table 2) is closest to the melting point of trans-cinnamic acid. To confirm this, the melting point of the unknown compound was tested next to trans-cinnamic acid and a 50-50 mix of trans-cinnamic acid and the unknown compound. As seen in table 3, while the start point of each of the compounds varied, all three of the compounds had an extremely similar end point.
“Panacetin” is a common painkiller. It is known that Panacetin contains 8-12% sucrose, 35-45% aspirin, and 45-55% of another unknown active ingredient, but if counterfeited, this active ingredient would most likely be acetanilide or phenacetin. In this experiment, students are given a sample of Panacetin that is suspected to be a counterfeit . Students are instructed to separate its components and calculate what percentages of aspirin, sucrose, and the unknown component are present in the drug in order to determine if the composition is stated accurately on the label. Different filtration techniques were employed in order to obtain the pure components of the drug. Once the unknown component was obtained, it was possible to take the melting points of the unknown, the unknown mixed with acetanilide, and the unknown mixed with phenacetin. The melting points were compared in order to identify the unknown.
Antivenin is a drug that has always been fascinating to me, as it has affected my life personally in the past. My mother was stung by a deadly baby scorpion while I was in the womb, and I was immediately injected with antivenin via my mother's IV. Because of this, I've always been curious about this drug. I think it will be a good opportunity to discover the properties of a drug that I may owe my life to. There are a lot of important details surrounding the use of Antivenin, regarding proper dosage, and the commonly seen side effects associated with it's use. I would like to use this paper as an opportunity to discover the many methods of obtaining antivenin, and how it is administered. I will also discover and go into detail about the history
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The product portfolio includes Acetadote® (acetylcysteine) Injection for the treatment of acetaminophen poisoning, Caldolor® (ibuprofen) Injection, the first injectable treatment for pain and fever approved
If a substance is pure, the melting points would be similar; however, for the 50-50 mixture, the melting point was depressed due to the amount of impurity between the two substances. In part two of the experiment, in order to determine the identity of the unknown substance, the compound was heated rapidly at a rate ramp of 10C in order to find the approximate melting point. The substances were similar in ranges as the unknown held a value of 3.8 while acetanilide had a value of 3.7. By using the melting point 115.2C-119.0C, it was determined that the unknown substance was most likely acetanilide. After testing the unknown mixture with acetanilide, it was confirmed that the unknown chemical was in fact
As a powder, specialists and high-profile researchers use it in their procedures to perform extensive research. However, it is advisable always to wear gloves, masks, and other protective garments when performing research using Etizolam and other chemicals because most of them are toxic and they can bring harmful side effects to the human body.
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Acetanilide also known as antifebrin is an analgesic and has fever reducing properties. It is similar to a class of drugs known as acetaminophen which is the main ingredient of the over the counter drug Tylenol. In the 1940 it was discovered that acetanilide is much more toxic analgesic than other drugs, and therefore was abandoned. Acetanilide has a melting point of 114.3 ° C and boiling point of 304 ° C. Acetanilide is also soluble in water. The main reactants used to create acetanilide are aniline and acetic anhydride, but there are numerous ways to synthesize it.