Illustrations of Poly-Pharmacology in Dietary Phyto-nutrient is Curcumin

This paper hopes to share insight into the steps that are taken by companies, and the strenuous process behind developing an effective new drug.

According to Dr. William LaValley, who focuses most of his clinical work on the treatment of cancer, curcumin—a derivative of turmeric, and the pigment that gives the curry spice turmeric its yellow-orange color—may fit the bill. It's a natural compound that has been extensively researched, and has been found to have numerous health applications.

Tickoo, S. (2002). Drosophila melanogaster as a model system for drug discovery and pathway screening. Current Opinion in Pharmacology, 2(5),

Curcumin has also been discovered to decrease the risk of forming liver cancer. It does this by decreasing the effects that human carcinogens, for example, thioacetamide, have on the liver.

Cancer is the second leading cause of death in the United States. As of 1990, there has been estimated 5 million people who have been taken by the disease. Every one of four people in the U.S will die of cancer, averaging at 1,500 people per day. There are many things in our daily lives that contribute to the growth and spread of cancer. The food and chemical industries take the blame. Naming it the “man made disease.” What many people do not understand is that there are other treatment options rather than chemo and radiation therapy. One of these alternative treatments is natural medicine. Natural medicine is beneficial because people have

The chemistry of heterocyclic compounds is one of the most complex and intriguing branches of organic chemistry, of equal interest in its theoretical implications, for the diversity of its synthetic procedures, and for the physiological and industrial significance of heterocycles. One of the most important heterocyclic scaffolds is quinoxaline. Quinoxaline is a bicyclic heterocycle consisting of a benzene ring fused to a pyrazine, hence a quinoxaline is also called Benzo[a]pyrazine, Benzopyrazine, Benzoparadiazine,1,4-Benzodiazine, Phenopiazine, Phenpiazine, Quinazine, and Chinoxalin. It is isomeric with quinazoline, phthalazine, and cinnoline (Figure 1).

High throughput screening (HTS) is essential in the process of finding a potential drug candidate, and automation is key for a good screen both in terms of robustness and reproducibility.

To first identify novel drug targets, I would thoroughly search the literature, look at online cancer resources and discuss potential targets with scientific experts at the Beatson and externally. Below I have outlined the key information that should be gathered.

Ng, Rick. Drugs: From Discovery to Approval. 3rd ed. Hoboken, NJ: John Wiley & Sons, 2015.

Turmeric has two very distinct healing traits, the first is prevention by infusing the body’s systems with natural nourishments to thrive and the second it enforces and fights the infection and cause for the heart abnormalities. Curcumin has the ability to reverse progressive heart disease by improving the arterial endothelium or what we know as the inner lining of the blood vessels associated with the heart. It helps to relax these vessels and acts as a blood thinner, so the blood flows easily through the vessels normally, eliminating chest pains, and improving blood pressure, combined with exercise it can be very effective in preventing heart attacks.

Alternative treatments such as pomegranate juice and pomegranate extract could offer treatment to slow or even stop the growth of malignant tumors, by interfering with the cell’s growth cycle. Intravenous vitamin C offers a treatment which helps patients deal with their high fatigue and anxiety that comes with having cancer, and even their social and cognitive function, as well as their immune system. Medical marijuana offers an alternative selection to those looking to manage their pain without the use of narcotics, or help those who suffer with chemotherapy induced nausea and vomiting, as well as promote weight-gain. In a diverse society, a diverse selection of treatments should be available. With more research and FDA approval, the implementation of these few complementary or alternative treatments for cancer could allow the pharmaceutical industry to offer a broader offering of medicines for those who are looking for something with fewer side effects, or even those who have exhausted the current, most popular treatments. Treatment of any disease, especially a disease as unpredictable and deviant as cancer, should never be limited to a one-size-fits-all

Turmeric has an active ingredient called curcumin. It stops the development of cancer by interfering with aspects of cell signaling of chronic disease. Curcumin helps prevent many forms of cancer, including breast, lung, stomach, liver and colon due to its anti-inflammatory and antioxidant properties.

The polyhydroquinoline motifs range prominent among nitrogen containing heterocycles due to their occurrence in a broad range of biologically active natural products & pharmaceuticals. 1, 4-Dihydropyridine (DHP) scaffold is an important pharmacophore found in a large number of biologically active and potential therapeutic compounds. DHP is a diverse pharmacologically active motif which is useful for clinically validated therapeutic agents such as amlodipine, lacidipine, nicradipine and also many

We marked the drugs and small compound molecules in the intersection of transcriptomic and cell morphological profiles, and collectively, transcriptomic ($T$) and cell morphological ($C$) profiles of 9515 drugs and small compound molecules were provided as a back-end data for our proposed pipeline. Finally, we standardized the transcriptomic and cell morphological profiles via \textit{unitization with zero minimum} ($\frac{x-minimum}{range}$), where $x$ is a non-missing values in a vector of numerical values representing changes of a variable.

1Drug Discovery Research Center, Luzhou, Sichuan, People 's Republic of China; 2Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO, USA