Imaging Biomarkers And Their Implications For Tumor Heterogeneity

3618 Words Jul 1st, 2015 15 Pages
Babak Saboury, MD, MPH; Sepideh Panahi, MD; Robert Morales MD; Eliot Siegel, MD
Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland Medical Center, Baltimore, MD, USA
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Radiomics and Personalized Medicine:
Imaging Biomarkers and their Implications for Tumor Heterogeneity Introduction

Cancer is the cause of death in one out of four people in the United States.{Cronin, 2014 #124;Ward, 2014 #128} The mortality rate has been almost constant in spite of all new discoveries to cure cancer in the past few decades{Cronin, 2014 #124}. This shows that several contributing factors play major roles. The practice of clinical oncology focuses on the diversity on cancer cells. Researchers have found that tumors from different subpopulations of cells can harbor very different characteristics, thereby displaying differing biologic characteristics including degree of differentiation, growth rates, and response to various therapeutic interventions{Marusyk, 2010 #130}. There are two emerging concepts in tumor biology: intertumor and intratumor heterogeneity. intertumor heterogeneity occurs among various malignancies, i.e. different biological characteristics between different histological subtypes, while intratumor heterogeneity represents different biological characteristics within the sub-populations of neoplastic and non-neoplastic cells that continuously evolve within a tumor mass {Gatenby, 2013 #1257;Gillies, 2013…
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