Immunological Theory of Aging Essay

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Throughout history, mankind has been obsessed with discovering a cure for any ailments or disorders that could disrupt or hinder their short lives, especially those to evade the aging process. With society becoming increasingly interested in everlasting beauty and living longer, the race to discover the main contributor toward aging begun in the early nineteen hundreds. In the midst of this quest, several biological theories had been developed. Among these theories is the immunity or immunological theory. This paper will discuss the immunological theory of aging by explaining the theory, giving a history of its origin and a description of further development within the evolution of the theory. Aging, as exhibited within the immunity…show more content…
During this same time, immunologists and cell biologists were in a stalemate of debates focused on aging in respect to their individual fields. In the same period, a cytokine that was found to have promoted T-cell proliferation within cellular culture was discovered, promoting a flourish of immunology papers announcing the discovery of proof that the “unlimited growth of normal human T-cells” existed and directly countered the biologists’ Hayflick limit programmed aging theory (Effros, 2005). However, intrigued by the constant conflict of these two groups of researchers, Walford anxiously investigated whether or not the claim that human lymphocytes cultured were in truth restricted by the Hayflick limit was true (Effros, 2005). In order to come to a solution to the question, Walford systemically analyzed the proliferative potential of the lymphocytes. These cells derived from the peripheral blood of young adult donors were propagated in the cell culture with repeated stimulation of an antigen (Effros, 2005). Continuous exposure to the T-cell specific growth factor interleukin-2, concluded with a mean number of population doublings, showed a steady decrease between the ages of 25 and 40 (Effros, 2005). With the continuous repeat of this data, Walford’s reasoning began to

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