Importance of Steriochemistry

2434 Words Mar 22nd, 2011 10 Pages
ASSIGNMENT ON

PHARMACEUTICAL IMPORTANCE OF STEREOCHEMISTRY

PREPARED FOR: Nowshin Nowaz Rumzhum Lecturer, Dept. of pharmacy Stamford University Bangladesh

PREPARED BY: Md. Wahid Rezwan ID No: BPH02805674 Batch No: 28th D

STAMFORD UNIVERSITY BANGLADESH

Introduction: Stereochemistry may seem like a trivial subject because differences between stereoisomers are usually subtle. In nature, however, and most importantly, in biological systems such as the human body, these subtle differences have sweeping implications. Most drugs for example, are often
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CHIRALITY AND ENANTIOMERS:

This section contains the basics needed to understand chiral drugs. Undergraduate textbooks in chemistry are good resources for a more thorough discussion of chirality and enantiomers. The most important point is that chiral drugs have 2 structurally similar forms that can behave very differently in biological systems due to their different shapes in 3-dimensional space. These 2 possible form sare termed enantiomers, and the 2 enantiomers of a given chiral drug should be considered 2 different drugs. This topic is discussed further in the next section. each chiral center. Optical rotation is often used because it is easier to determine experimentally than absolute configuration,but it does not provide information about the absolute configuration of an enantiomer. For a given enantiomer pair, one enantiomer can be designated (+) andthe other as (–) on the basis of the direction they rotate polarized light. Optical rotations have also been described as dextrorotatory for (+) and levorotatory for (–). Racemates can be designated as (R,S) or (±).

CHIRAL DRUGS IN BIOLOGICAL FIELDS:

Chiral drug have identical physical and chemical properties in an achiral environment. In a chiral environment, one enantiomer may display different chemical and pharmacologic behavior than

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