Influenza Virus ( Kapoor And Dhama 2014 )

According to Center for Disease Control (CDC), influenza viruses are divided into three types, designated as A, B, and C. Influenza type C usually only causes either very mild symptoms or no symptoms at all. Types A and B, however, are responsible for epidemics of respiratory illnesses that can result in hospitalization, or even death. Influenza is constantly changing over time by mutations. This continual change allows the virus to evade the antibodies that were meant to kill it. A host infected with influenza virus develops antibodies against that virus; as the virus changes, the "first" antibody no longer recognizes the "newer" virus and infection can occur because the host does not recognize the new flu virus as a problem until the infection is well under way. The first antibody developed may, in some instances, provide partial protection against infection with a new influenza virus. According to Medicine Net.com, In 2009, almost all individuals had no antibodies that could recognize the novel H1N1 virus immediately. It quickly spread throughout the world so fast that the WHO declared this new flu strain (termed novel H1N1 influenza A swine flu). There are currently four main strains of influenza circulating worldwide. Three of the viruses are type A, and one is type B. Type A viruses are divided into subtypes based on the differences in two viral proteins called hemagglutinin (H) and neuraminidase (N). The three subtypes of influenza A are A(H1N1), A(H3N2), and A(H5N1). The reason for several strands of type A are because of the two kinds of change influenza A

Throughout the history, influenza viruses have caused several pandemics or global epidemics, killing many people. For example, the influenza strike in 1918 to 1919 infected an estimated 500 million people worldwide, which is one-third of the planet’s population at the time and killed an estimated 20 million to 50 million people. More than 25 percentage of the U.S. population were affected, and caused 675,000 deaths in U.S during the pandemic.(History, 2015). There were no effective treatments for this type of influenza and no available vaccines can prevent its spread during the period. (History, 2015) U.S government required general population to wear masks and other protective equipments in public areas, and many public places also closed due to the influenza strike. Health care providers tried everything they knew to save people, but none shows any evidence of effects. (National Center for Biotechnology Information [NCBI], 2015). Scientists found out that the influenza virus had invaded their lungs and caused pneumonia, which made so many people died from the pandemic (History,2015). Another influenza strike happened

Every year, millions of people start talking about the influenza virus and getting their vaccines as the flu season approaches, which starts around the October-November period and reaches its peak between December and March. Therefore, public health officials around the world- and in the U.S in particular- are constantly challenged by properly preparing for the annual influenza dilemma, given that this viruses, and other respiratory viruses, are a serious health threat to the U.S population and the world as a whole. Furthermore, what makes the influenza virus even more challenging to control is that it can mutate rapidly and reassort to form new strains, having the ability to reside in multiple animal hosts. In fact, many scientists and researchers have been doing in-depth intensive research so as to understand the mechanism behind this unique characteristic of the virus, try to find new ways to control it, and explore different areas of protection and vaccination.

Influenza is very contagious and spreads rapidly from person to person. Influenza causes worldwide yearly epidemics. According to World Health organization Influenza affects 5-15% world’s population and resulting in 500,000 deaths yearly. Ottenberg stated that, in United States, an average of 200,000 were hospitalized and 36,000 died each year from influenza complications. Influenza is the sixth leading cause of death among US adults and is related to 1 in 20 death in persons older than 65 years. Disease control and prevention estimates indicate that infections like H1N1 which is one of the types of influenza, have resulted in an estimated 42 to 86 million cases and 8520 to 17620 deaths. As I mentioned earlier that infections like

Influenza, normally called “the flu”, the influenza virus causes an infection in the respiration tract. Even though the influenza virus can sometimes be compared with the common cold. It also can cause a more severe illness or death. During this past century, pandemics took place in 1918, 1957, and 1968, in all of these cases there where unfortunately many deaths. The “Spanish flu” in 1918, killed approximately half a million people in the United States alone. It killed around 20 million worldwide. The “Asian flu” in 1957, in the United States their 70,000 people died. In 1968 the “Hong-Kong flu” There where 34,000 deaths in the United

Avian influenza is a disease that has been wreaking havoc on human populations since the 16th century. With the recent outbreak in 1997 of a new H5N1 avian flu subtype, the world has begun preparing for a pandemic by looking upon its past affects. In the 20th Century, the world witnessed three pandemics in the years of 1918, 1957, and 1968. In 1918 no vaccine, antibiotic, or clear recognition of the disease was known. Killing over 40 million in less than a year, the H1N1 strain ingrained a deep and lasting fear of the virus throughout the world. Though 1957 and 1968 brought on milder pandemics, they still killed an estimated 3 million people and presented a new

Influenza virus has been causing recurrent epidemics of acute febrile syndrome every 1 to 4 years for at least recent centuries. The first epidemic report of the influenza like illness was noted in 1173-1174,1 but the first definitive epidemic was reported in 1694.2 The greatest pandemic in recorded history occurred in 1918-99 when approximately 21 million deaths were recorded worldwide.3 it was among the deadliest events in reported human history. After that Three others have occurred in the twentieth century: the 1957 H2N2 pandemic, the 1968 H3N2 pandemic and the 2009 pandemic influenza A (H1N1) virus (pH1N1). In the recent event an influenza strain with a combination of gene segments not previously reported in swine or human influenza virus

The virus has been studied in detail during 2009-2010. Being a complex virus, it is important to study the current scenario and the trends of the circulating virus. During 2015, the incidence of pandemic H1N1 2009 influenza virus among patients presenting with ILI, diagnosed in our tertiary care hospital during the study period was 18.6%. In the 2012-2013 the incidence of pandemic H1N1 2009 influenza virus among patients presenting with ILI, was 8.20% indicating a sharp increase in the number of cases. 9 After 2010, the 2009 pandemic H1N1 influenza A reappeared in several northern and western states of the country during the winter months of 2012-2013. The presently ongoing resurgence since December 2014 however appears to be worse than the previous one, leading to over 30,000 cases and 2000 deaths countrywide (as of 28th March,2015) as compared to 5044 cases and 405 deaths in 2012 and 5250 cases and 692 deaths in 2013.10 The resurgent waves lead to more number of hospitalizations and deaths due to pdmH1N1 as compared to the rest part of the year and appear at an interval of 1.5-2

It is caused by various types of influenza viral strains. According to Marjorie, three types of influenza viruses are recognized: A, B and C. Type A is more common. Influenza virus belongs to the Orthomyxoviridae family, are enveloped, pleomorphic, and contain the genomes of 8 single-stranded negative-sense segments of RNA. Influenza viruses have three key structural proteins: hemagglutinin (HA), neuraminidase (NA) and Matrix 2 (M2). Both HA and NA are surface glycoproteins diverse enough that their serological recognition gives rise to the traditional classification into different subtypes.

Influenza is a viral infection that attacks your respiratory system — your nose, throat and lungs. The virus is sphere covered with spike like proteins, called the hem agglutinin and the neuraminidase, ready to latch on to a healthy human cell. The process of entering a cell, reproducing, and moving to another cell takes about 4 to 6 hours. There are multiple complications of the influenza virus such as Guillain-Barre syndrome and Reye's syndrome. The most serious complication is pneumonia. When having the flu, you can have a bunch of symptoms. Headaches, fever, runny nose, coughing, sore throat, body aches, and tiredness are a few symptoms of the flu.

Influenza is a virus that is transmitted mainly via airborne process, which is one of the fastest mode of transmission. It is transmitted though airborne due to symptoms such as coughing and sneezing of the host (the infected). The host sneezes and coughs, influenza can easily be transmitted the agent via droplets and small microorganism, therefore entering the uninfected though the respiratory system (mouth and nasal) (WHO, 2016). Another way the virus can lead to pandemic, is due to the fact that the number of human and animals continue to grow and interact. Thus, the pandemic of influenza type A is possible. This mode of transmission is both and; the airborne (respiratory system) and physically (hand contamination). The customarily begins in rural areas (farms) as the virus can be found in hosts such as horses, pigs, chickens and birds. There has been an undetected interchange of the disease among animals and humans in rural environments which then eventually grows to become a global pandemic (Webster, RG & Monto, AS et al 2013, Textbook of influenza). The virus may continue to spread physically due to hand contamination in public; these may include door handles, public transport and other hand held hold objects. The last mode of transmission is genetically, this may then lead to asthma or even death (WHO,

Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza viruses that causes regular outbreaks in pigs. People do not normally get swine flu, but human infections can and do happen. Swine flu is also known as pig influenza, swine flu, hog flu and pig flu. This is a viral disease caused by several type swine flu viruses known as Swine influenza virus (SIV) or swine-origin influenza virus (S-OIV) which is a strain belongs to the influenza family and endemic to pigs. There are several subtypes of Influenza A virus known as H1N1, H1N2, H2N1, H3N1, H3N2, and H2N3. CDC has determined that this virus is contagious and is spreading from human to human. However, at this time, it not known how easily the virus spreads between

The bird flu virus, also called avian influenza (flu), is a highly pathogenic type A virus which mainly infects the respiratory system in wild aquatic birds. This very contagious virus has also been known to sicken and kill domestic birds such as chickens, ducks, turkeys and other animals including people. (CDC, n.d.). Unlike the seasonal winter flu, where there is usually some immunity from previous exposure, vaccine is readily available, and the public health system can meet patient needs, the virulence of the avian influenza type A virus and its ability to infect people of all ages with various degrees of health, causes many concerns. Any introduction of a new virus into the human population with little or no immunity against it could

Restate Thesis: Influenza is a common virus that is present in almost every part of the world. Studies show that influenza causes people to be prevalent to other diseases, especially respiratory diseases. According to an article on The Lancet, August 14th, 2009 by Jamieson, the virus caused the widespread outbreak of respiratory infection

With a huge number of victims, 80 to 100 million, since 1918, the influenza is considered as one of the most pandemic diseases ever. There are three types of influenza virus: influenza virus A, influenza virus B, and influenza virus c. These are a subtypes of the virus family orthomyx-oviride. The types B and C do not cause pandemic diseases while type A does. The type A classified into three main subtype H1.N1, H1.N2, and H3.N2. The (H.N) refers to the two kinds of proteins on the surface of the virus (hemagglutinin and neuraminidase). The difference in numbers is due to the difference in protein variability. A H1.N1 virus which is widely known as Spanish flu is the only type that can transmit from human to human. The H5.N1, or “bird flu”