Specific Purpose: To inform my audience about type one diabetes and the dangers of living with it.
Thesis Statement: Type one diabetes is a dangerously incurable disease due to the blood’s sensitivity to sugar, inadequate insulin production, and the lack of types of treatments.
Title: Type One Diabetes
Introduction:
I. Imagine that every time you ate, an hour after, your body felt like it had just eaten ten Thanksgiving dinners. For a diabetic, this feeling is known all too well. Type one diabetes is an autoimmune disease that affects the pancreas. Only ten percent of diabetics are type one, with the remaining ninety percent accounting for type two. Many serious complications can arise if diabetes is left untreated, with the worst outcome being
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Body:
I. In healthy people, the pancreas effectively regulates blood glucose (BG) levels without showing any signs of its work. A. Beta cells in the pancreas are responsible for the production of insulin, which is released in response to rising blood sugar levels. B. For a diabetic, this silent process is a luxury that their pancreas can’t afford. 1. Klandorf states that the body’s own T lymphocytes progressively attack the beta cells until they are destroyed, halting the production of insulin. 2. The effects of insulin greatly outweigh the body’s ability to bring up its BG leading to the dramatic BG fluctuations.
(Transition): Though the BG seem uncontrollable, this usually naturally occurring hormone can be administered to lower these rising BG levels.
II. According to Kirsten O’Brien, there is a great analogy for explaining the action of insulin.
A. (Demonstrate story)
B. This is how the process occurs many times each day.
(Transition): In diabetics, this entire mechanism is hindered, leading to high BG levels.
III. Though the sugar regulating process seems to go unnoticed, the body makes sure to alert when the BG levels are
Type 1 diabetes is a disease that is most commonly diagnosed in children, is rarely diagnosed in adulthood, and “Diabetes at a glance” (2016) reveals that nearly two million people were newly diagnosed with the disease in 2016 in the U.S. alone, and one of the people included in that two million is myself. Throughout the
Type 1 diabetes is also called insulin-dependent because the pancreas produce little to no insulin due to the destruction of beta cell in pancreas(Bardsley et al, 2004). Therefore, the insulin have to be injected manually for body to function normally. (Seewaldt et.al, 2000) states that in type 1 diabetes, the beta cell located in the islets of Langerhans have antigen that cause the immune system to produce antibodies and kill the insulin producing cells. The autoimmune response is thought to be caused by the autoreactive CD4 and CD8 effector cells that recognise islet self-antigens, as an outcome there is greater than 90% destruction on insulin producing cell BACH (1994). Similarly, (Nakayama et al,2005) and (Kent et al, 2005) supports that insulin in itself is a
Type 1 diabetes is a chronic illness characterized by the body’s inability to produce insulin. Onset most often occurs in childhood, but the disease can also develop in adults in their late 30s and early 40s. The classic symptom of type 1 diabetes is: The need to urinate frequently, excessive drinking as a result of thirst, excessive hunger and abnormally large intake of solids by mouth. Unexplained weight loss, Other symptoms may include fatigue, nausea, and blurred vision. The onset of symptomatic disease may be sudden and is a classic sign of diabetes mellitus that is under poor control or not under treatment
For this assignment, I interviewed a thirty-two year old African American male with type-one diabetes. I learned having this particular disease is difficult to manage; nutritious eating, exercise, watching their disorder, taking medication and reducing their risk for problems are usually part of your their day-to-day routine. It seems that all of this is pretty overwhelming and there are two main types of diabetes (type-one and type-two). This particular illness distresses your body’s capability to generate or use insulin. Insulin is a hormone. When your body turns the food you eat into energy, it’s usually referred to as glucose or sugar. If you produce little or no insulin, or are insulin resistant, too much sugar rests in your blood. Blood glucose levels are greater than standard for individuals with diabetes. The cause of diabetes is unknown. Genetics, diet, obesity and lack of exercise may play a role in developing diabetes, specifically in cases of type-two diabetes.
For this speech, I will be focusing on Type 1 (What Is Type 1 Diabetes?). BODY First main point: First, Diabetes is a common chronic disease without a known cause or cure. In 2015, 30.3 million Americans (9.4%) had diabetes, with approximately 1.25 million having type 1 diabetes (Statistics About
Type one diabetes is an autoimmune disease. There are cells in the pancreas that produce insulin, the hormone that regulates the amount of insulin in your blood and
Type 1 Diabetes, also called “insulin-dependent diabetes”, “juvenile diabetes”, or “early-onset diabetes”, is when the pancreas produces little to no insulin. Type 1 diabetes is not as common as type 2, but 10% of all diabetics are type 1. Patients with type 1 diabetes will need to take insulin injections for the rest of there lives. Also people with type 1
Homeostasis controls the glucose level in the body. Glucose is a small soluble molecule that is carried in the blood plasma and it deliver energy to the cells to function properly. The core level of glucose in the blood is about 4.5-5 millimole/litre. If the level raise above or falls under the core level on the long-term basis, it will modify the behaviour of the cells and serious health problems can arise. The pancreas plays a vital role in regulating blood glucose. The pancreas is a dual-purpose gland. It produces digestive enzymes in cells called acini, but also has an endocrine function. Within the acinar tissues are cell clusters known as islets of Langerhans, which produce hormones involved in controlling the blood sugar – the body’s
I hate my diabetes. I wish I could take a vacation from it and eat a slice of cake without calculating carbohydrates. But, I can’t. So instead, I’ve learned to flip things around, and use the challenges of diabetes as an inspiration to live as fully as I would if I didn’t have diabetes. Living with Type One is an exercise in judgments, measurements, willpower and self-restraint.
Type 1 diabetes is a serious chronic condition that tends to arise prior to adulthood. The disease requires substantial lifestyle changes in order to cope, and can lead to several debilitating outcomes if left unchecked. According to the American Diabetes Association ([ADA], 2017), Type 1 diabetes is defined as a chronic condition where the body no longer produces the insulin hormone, and is therefore unable to utilize and store glucose. As a result, individuals with Type 1 diabetes may experience excessively high or low blood glucose levels: hyperglycemia and hypoglycemia respectively (ADA, 2017). Both sides of the spectrum can have devastating effects on the body’s cardiovascular and renal activities, in addition to deteriorating the peripheral
Low blood glucose levels are detected by the alpha cells of the pancreatic islets, which respond to hypoglycaemic stimuli by producing the hormone glucagon. Glucagon is a polypeptide hormone that acts in an antagonistic way to insulin, causing blood glucose levels to rise and promote processes that spare glucose utilisation. It has a powerful effect on the liver which stimulates the production of glucose from stored glycogen and amino acids. The insoluble glycogen molecules found in muscle and liver cells is able to be converted back into soluble glucose molecules which then dissolves into the bloodstream, rising blood glucose levels, and glucagon therefore having a hyperglycaemic effect on the body. This process is called gluconeogenesis.
Type 1 Diabetes effects millions of people around the world (Michel & Montada-Atin, 2014). Most often, a person is diagnosed before their 30th birthday, with diagnosis commonly being between 11 and 13 years of age (Michel & Montada-Atin, 2014). Diabetes is a disease of the pancreas. More specifically, the breakdown of β cells in the pancreas causes the production of insulin to cease (Michel & Montada-Atin, 2014). Once the body is unable to
The homeostatic mechanism that blood sugar regulation falls under is negative feedback. After blood sugar drops and glucagon is released, glucagon will increase blood glucose to an ideal value in order to maintain a stable internal condition. After sugar levels have returned to normal, glucagon release is then suppressed by rising blood glucose levels and insulin. After insulin is secreted due to increased blood sugar and muscle and fat tissues absorb the glucose, the glucose level will begin falling below a threshold, and beta cells will then inhibit secretion of insulin to restore homeostasis. There must be a working relationship between glucagon and insulin and they both must be operative in order to maintain a homeostatic balance.
The purpose of blood glucose regulation is to maintain the levels of blood sugar in the body at homeostasis. As humans, our bodies rely on our blood glucose levels to be maintained within a very small range (approximately between 5mM and 10mM). It is important for blood glucose levels to remain stable and within these approximate boundaries because the brain and body struggle to function properly outside of this range. Insulin and Glucagon are both pancreatic endocrine hormones secreted from the pancreas in order to maintain homeostasis in blood glucose regulation. It is the production of these hormones that is necessary in humans in order to prevent diseases such as diabetes or hypoglycemia from developing.
Type 1 is characterized by the body’s inability to produce insulin. It is caused by autoimmune-mediated destruction of pancreatic beta cells, which are responsible for producing insulin. There appears to be a hereditary link in people with Type 1 diabetes. Other factors have been known to cause Type 1 diabetes such as viral infections, toxins, and other environmental factors. Type 1 diabetes is the rare form, affecting about 10% of the diabetes population. Its onset usually occurs in people less than the age of 20.