Insulin Deficiency Research Paper

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Insulin deficiency also causes protein metabolism in skeletal muscle.This leads to increased release of alanine to the circulation.These substances then enter the liver where they are used as substrates for gluconeogenesis which is overly stimulated in the absence of insulin and the elevated glucagon.The increased rate of glucose production in the liver,coupled with the glucagon-mediated inhibition of glucose storage into glycogen results in the overproduction of glucose release from the liver and leads consequent hyperglycemia.
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