Insulin Lispro

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Insulin lispro (Humalog) manufactured by Eli Lilly and it is the first rapid insulin to receive approval by the FDA in 1996. The insulin sequence at the position B28 (proline) and B29 (lysine) reversed to form lispro figure (1). The onset of activity is 15 minutes, peak action 60-90 minutes, and duration (3-4 hours); injected shortly before meals (0-15 minutes). Therefore it stimulates physiological insulin secretion relative to meals. The FDA approved the insulin lispro (Humalog) for pediatric patients from 3 years and older, and it is pregnancy category
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