Insulin Type 2 Diabetes

The body tends to deal with this imbalance by filtering out excess glucose throughout the kidneys, resulting in high levels of sugar in the urine. As glucose level rises the kidneys over-whelmed and don’t function normally. They lose their ability to absorb much water the result is frequent urination. This is commonly the earliest sign of diabetes. It is often followed by unquenchable thirst as the body tries to regain the lost fluids. It often seems that more fluid comes out than went in.

When your body is found to have too much glucose in it, your body isn’t making enough insulin or the insulin is working correctly to help move the glucose through the blood into the cells. Your pancreas make insulin and puts it in your blood stream. The glucose stays in the blood and doesn’t get to the cells to be used up.

He said, diabetes mellitus is a chronic disease that occurs when the body doesn 't make enough of insulin, or the body doesn 't use insulin properly. Insulin is a key to regulation of blood glucose in our body. In types II diabetes a condition of when insulin insensitivity as a result of insulin resistance that decreases insulin production and eventual pancreatic beta-cell failure enough insulin to meet body needs. Impairment of beta- cell also can lead to problems with insulin production and resistance that can interfere with the process of glucose uptake in by cells and muscle. This condition leads to a decrease in glucose transport into the liver, muscle cells, and fat cells which can lead to a condition called hyperglycemia. Hyperglycemia occurs when there is a high level of blood glucose levels in our blood (Concepts Advisory Panel (2015) p.742).

Diabetes mellitus, is the fancy way to say diabetes but many people referred it as diabetes. Diabetes is a group of metabolic diseases which can cause you to have high blood sugar levels over a long period. The two main types of diabetes are type 1 and type 2. Type 1 results from the pancreas's failure to produce enough insulin. This form was previously referred to as "insulin-dependent diabetes mellitus" or "juvenile diabetes". The cause is unknown. Type 2 begins with insulin resistance, a condition in which the cells fail to respond to insulin properly. There is no known preventive for type 1 diabetes, Or Type 2 diabetes which accounts for 85-90% of all cases can often be prevented or delayed by maintaining a normal body weight, engaging

Glucose regulation is determined through a loop feedback system where the production of insulin is based off the reaction of B-cell to insulin sensitive tissue. B-cell reaction determines the level of insulin that is produce in the body. Normal regulation is dependent on the b-cell response and when the b-cell response is inadequate and is unable to produce enough insulin in the body, insulin resistance diabetes (diabetes type 2) is present. There are a number of causes for diabetes including genetics, obesity, low or no level of physical activity, unhealthy diet (high in fat and sugar), smoking, and alcohol consumption; with obesity being the greatest factor. With diabetes type 2 comes many risk factors such as, increase

Diabetes Type 2 is a lifelong disease that develops slowly. Type 2 diabetes causes the person fat, liver and muscle cells not to respond correctly to the hormone insulin, as a result the glucose doesn’t get into these cells to be stored in energy, which causes the levels of blood sugar in the blood to increase and eventually causing damage to the nerves and small blood vessels of the eyes, kidneys and heart and lead to atherosclerosis or the hardening of the arteries which causes a heart attack or stroke. Common symptoms of diabetes type 2 is fatigue, hunger because the body can’t process the food properly so its expelled through urine, increased thirst because the person keeps peeing out everything they are consuming which makes them thirsty,

Even with the improvements in diabetes control and patient care, Type 2 diabetes is associated with a higher risk of death than the general population. For the current modelling analysis, the relative risk (RR) of death was estimated to be 2.45 for patients with DME and this was estimated based on the results from two studies. Mulnier et al. reported a RR of 1.93 (95%:CI: 1.89 to 1.97) for diabetic patients when compared to the general population.23 In the second study, Hirai et al., determined that the RR of death in diabetic patients with clinically significant macular edema was 1.27 (95%CI: 1.01 to 1.61).24 By combining the two estimates, the overall RR of mortality used in the model was 2.45 (i.e. 1.93 x 1.27).

Insulin has been used for diabetes since 1922. “Leonard Thompson, a 14-year-old boy dying from diabetes in a Toronto hospital, became the first person to receive an injection of insulin” (“The History of a Wonderful Thing We Call Insulin” 1). Without insulin, thousands of people with diabetes would die. Insulin is available for people who need it because it was initially tested on animals. Oskar Minkowski and Joseph von Mering removed a pancreas gland from a dog in 1889, and it ended up dying later (“The History of a Wonderful Thing We Call Insulin” 1). Animals like dogs, have hormones in their blood so the experiment worked on them. It wasn’t safe for humans yet (Parry 1). Although putting an animal’s life at risk for medical research might

Insulin works to control glucose levels in the body. When the pancreas doesn’t produce sufficient amounts or the insulin doesn’t function properly, diabetes occurs. Uncontrolled high sugar levels in the bloodstream produce familiar symptoms such as:

Diabetes type 2 is a condition in which blood sugar levels are too high. After eating foods that contain carbohydrates, chemicals in the small intestine break down the carbohydrates into simple sugar molecules called glucose. The cell lining of the small intestine absorbs the glucose, which then passes into the bloodstream. When the blood reaches the pancreas, beta cells in the pancreas detect the rising glucose levels. To reduce the glucose level, beta cells release insulin into the bloodstream. As the blood circulates through the body, the insulin and glucose exit the bloodstream into tissue to reach the body’s cells. Most cells of the body have certain receptors on their surface that bind to the circulating insulin. Insulin acts like a key in a lock to open up the cell so that the circulating glucose can get inside the cell. The cell can use the glucose to produce the energy it needs to function properly. If a person has insulin resistance, insulin cannot unlock the cells to let glucose in because the locks, called receptors, are abnormal and/or missing. As a result, glucose is locked out of the cells. The amount of glucose builds up in the bloodstream in a condition called hyperglycemia. To compensate for hyperglycemia, the pancreas produces more and more insulin. Overworked beta cells try to keep with the demand, but gradually lose their ability to produce enough insulin.

Diabetes type 2 is a condition in which blood sugar levels are too high. After eating foods that contain carbohydrates, chemicals in the small intestine break down the carbohydrates into simple sugar molecules called glucose. The cell lining in the small intestine absorb the glucose, which then passes into the bloodstream. When the blood reaches the pancreas, beta cells inside the pancreas detect the rising glucose levels. To reduce the glucose level, beta cells release insulin into the bloodstream. As the blood circulates through the body, the insulin and glucose exit the bloodstream into tissue to reach the body’s cells. Most cells of the body have certain receptors on their surface that bind to the circulating insulin. Insulin acts like a key in a lick to open up the cell so that the circulating glucose can get inside the cell. The cell can use the glucose to produce the energy it needs to function properly. If a person has insulin resistance, insulin cannot unlock the cells to let glucose in because the locks, called receptors, are abnormal and/or missing. As a result, glucose is locked out of the cells. The amount of glucose builds up in the bloodstream in a condition called hyperglycemia. To compensate for hyperglycemia, the pancreas produces more and more insulin. Overworked beta cells try to keep with the demand, but gradually lose their ability to produce enough insulin.

The body must keep a healthy blood glucose level so that there is a continuous supply of energy to the cells. If the blood sugar levels fall too low (hypoglycaemia) it can cause harmful complications such as fatigue and even loss of consciousness. If blood sugar levels raise too high (hyperglycaemia) it can lead to many difficulties such as cardiovascular disease, nerve damage and kidney damage (S Preet, 2013). This is why is important for the body to regulate its glucose levels. It does this by the pancreatic islets detecting a change in blood glucose levels, they then release the hormone insulin into the blood stream. Muscle cells are prompted by the insulin, to absorb glucose. The way insulin does this is by binding itself to receptors on the cell membrane, thuds increasing the amount of transporters and allowing more glucose to be transported into the cells. If glucose levels fall then another hormone is released by the pancreas called glucagon. Glucagon allows stored glucose (glycogen) to be released from the liver into the blood stream and raises blood glucose levels (Amis, 2011). This process of keeping blood glucose levels constant is an example of ‘homoeostatic control’ where the rise and fall of glucose levels allows each different hormone to be used in a constant

Insulin resistance is a fundamental aspect of Type 2 diabetes. Insulin lowers blood glucose by suppressing liver glucose production and increases glucose uptake into muscle and fat cells. The majority of glucose gets largely stored in the muscle and adipose tissue contributes little to glucose disposal. Insulin is a critical regulator of adipocytes as it promotes adipocyte triglyceride storage by helping preadipocytes get differentiated to adipocytes. Adipocytes are over 1 billion cells that specialize storing energy as fat and together they constitute the largest endocrine system that communicates to other tissues by adipocyte-released secretagogues including proteohormones lectin, adiponectin, and visfatin. (Redinger, R., 2007) Along

Certain hormones (insulin and glucagon) control the level of glucose in the blood. Insulin lowers blood glucose, and glucagon increases blood glucose. Hyperglycemia can result from having too little insulin in the bloodstream, or from the body not responding normally to insulin. Normally, the body gets rid of excess glucose through urine. If you

The pancreas is an extremely important organ for blood glucose homeostasis. The islets of Langerhan in the pancreas are composed of alpha and beta-cells which secrete hormones to help regulate blood glucose. When glucose levels are elevated the hormone insulin is released from the beta-cells in the pancreas. Insulin has several roles within the body. It stops the production of glucose in the liver, since you do not want more glucose to be added to the already elevated concentration of glucose in the blood (White & Kahn, 1994). It also binds to insulin receptors on the cell membrane of skeletal muscle cells, cardiac muscle cells, and adipose cells causing the GLUT4 transport to fuse with the cell membrane (Larance, et al., 2008). This allows