Integrated Pathology Case Study On Cardiovascular Disease

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Integrated Pathology Case Study

Multifactorial disease - Vascular Dysfunction in Heart Disease
BSc Biomedical Sciences

School of Healthcare Science
Faculty of Science and Engineering

Manchester Metropolitan University

Ayesha Iqbal 12109879

Cardiovascular disease (CVD) morbidity and mortality has reached epidemic proportions. Consequently, the importance of prevention of the disease, in addition to the treatment of the clinical outcome of the existing disease, has emerged as a priority in the field. These efforts have turned to what is in fact the underlying cause of myocardial infarctions and the resulting heart disease, specifically, atherosclerotic vascular disease.

This vascular condition affects the entire vascular tree and is also the cause of cerebrovascular and peripheral vascular disease (PAD), as well as the reason for major clinical complications such as restenosis and vein graft arterialisation. The development of atherosclerotic vascular disease involves a complex interplay of genetic, metabolic, cellular, and immunological factors, and understanding these factors is the first step in targeting heart disease.

Aetiology of the disease
• aetiology: describe the specific disorder and the biological basis of its cause of origin

CVD are diseases of the cardiac muscle or vasculature. The cause of most CVD is a build-up of atheroma a fatty deposit within the inside lining of blood vessels arteries. Atheroma is also known as
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