Introduction. Chronic Obstructive Pulmonary Disorder (Copd)

1383 WordsApr 15, 20176 Pages
Introduction Chronic Obstructive Pulmonary disorder (COPD) is a very prevalent disease in the world today with the most common cause being related to tobacco smoke. Not only is it associated with lung disease, but it has also been seen to be linked with many other comorbidities. However, the most concerning effect that COPD has on the body is towards the muscular dysfunction of skeletal muscle. Reasons, that are independent of lung function, that make this so concerning includes; an overall decrease in functional capacity, a poor quality of life, an increase in health care utilization, or even mortality. COPD has been linked to vitamin D deficiency. However, the effects of Vitamin D deficiency, pertaining to COPD, on skeletal muscle has…show more content…
The highest neutrophil count at roughly 35% is the vitamin D deficient smoking mouse at 18 weeks with little to no change over the course of time. This shows that smoking enhances and increases the effect of Vitamin D and vice versa when it comes to neutrophil count in the lungs. Fig 2 Figure 2 shows the change in body mass of the over the 18-week time. The control (normal air breathing and vitamin fed mouse) shows steady increase in body mass through all 18 weeks, starting at 26.7g and increasing to 32g. Second highest on the graph was the Vitamin D deficient mouse breathing normal air. This mouse did show increase in body mass but at a slower rate than the control, ending at roughly 29g and starting at 24g. The smoking vitamin D fed and vitamin D deficient mouse is when you start to see the major impact of smoking on skeletal muscle. Both stayed similar throughout the 18 weeks, only seeming to gain 2g of body mass from the initial ~24g. Fig 3 Figure 3 shows the percentage of gain in body mass compared to the initial mass of the body at the 6, 12, and 18-week time points. The vitamin D deficient groups showed the lowest percentage of body mass gain compared to the vitamin fed groups. Even though smoking was independent, and played no affect in body mass, the smoking vitamin D deficient mouse showed the lowest body mass gain at every single point. Table 1 Table 1 takes both muscle masses (mg) of the right and left of
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