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Introduction Sepsis is a critical condition caused by an overreacting immune response to an

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Introduction
Sepsis is a critical condition caused by an overreacting immune response to an infection. Most of the time, such infection are caused by bacteria. When a person is being infected, chemicals are released into the bloodstream to fight off infection. This may result in multiples inflammation found within the body. Inflammation can trigger a cascade of event which may cause multiple organ damage, leading to multiple failure of organs where the body is unable to function normally. In worst scenario, infection can lead to an increase in low blood pressure which rapidly leads to the failure of several organs causing death. Besides causing inflammation, it also causes increased in coagulation, decreased fibrinolysis and decreases the …show more content…

The knowledge of this topic do change overtime due to advance technology that progress year by year. In the past, people may have the thought of sepsis as a severe disease with no cure for it. Even if there is, not much could be done due to certain factors that must be accounted for. One such factor would be the cost of equipment. Also, looking at the point of view of a patient, money would most probably be a key problem for treatment. This result in the rate of mortality being high, leading to death. As for the 21th century, with advance technology, rate of mortality of sepsis could be reduce with the help of recombinant activated protein C invention.
Study patient
Patients used in the research are all adults who are contracted with sepsis (Donati et al, 2013). To make sure that the experiments are fair, group of people are registered in a randomized manner. Neither the patients nor the experimenters know which of the group being studied is a test group and which is a control group. This is to prevent the placebo effect from occurring (Shorr et al, 2010). Experiments are being conducted in different countries (Abraham et al, 2005).
Treatment assignment
Treatment was all done similarly regarding to the amount of dosage they used. One of the research was done using a recombinant activated protein C name drotrecogin alfa (DrotAA). Patients were randomly assigned

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