Introduction and Rationale for Conducting the Research

1871 Words8 Pages
Introduction and Rationale for Conducting the Research - Include in this section a brief review of pertinent literature and any available preliminary data. (1 page maximum) In the United States, salmonellosis is the second most common foodborne disease, with 800,000 to 4 million cases occurring each year with over 300, 000 hospitalization and approximately 500 deaths (4,13). Salmonella enterica serover Typhimurium colonize in the intestinal tracts of many mammals and birds, and one of the major routes of human salmonellosis is believed to be consumption and handling of contaminated poultry and poultry products (4). According to Food Safety and Inspection Service surveillance (FSIS), 11 to 16% of processed poultry carcasses were contaminated with Salmonella spp. (6). The most widely used option for reducing established Salmonella in poultry flocks is the addition of antibiotics to poultry feeds. However, due to the emergence of microorganisms resistant to multiple classes of antibiotics, there are public health concerns that such practices may lead to dissemination of antibiotic resistant pathogens and an increase of untreatable human diseases (5). Thus, strategies for the control and prevention of poultry colonization aimed at reducing the incidence of salmonellosis in humans are essential. An alternative approach for the control of pathogenic Salmonella spp. contamination of poultry is the induction of chicken immunity against Salmonella colonization. The idea of using
Get Access