Introduction to Addictions and Substance Use Disorders Essay

Most people do not completely know the definition of drug use and addiction, or the treatments that can be provided to stop it. The National Institute on Drug Abuse defines addiction as “addiction is a chronic disease characterized by drug seeking and use that is compulsive, or difficult to control, despite harmful consequences.” (National Institute on Drug Abuse). This definition gives an accurate representation of what addiction is, and how it can be such a serious problem. As given by the definition, addiction is a chronic disease, and when you have an addiction it is extremely difficult to quit. “Drug addiction is a complex disease”. It later goes on to state that “brain changes can be persistent, which is why drug addiction is considered a “relapsing” disease.” (National Institute on Drug Abuse). This shows why people

Brain chemistry can affect different addicts more then others. Drugs and alcohol are more of the main addictions that brain chemistry affects. Once taking these addictive substances your internal natural drug dopamine is lowers causing you to seek more external addictive substances. This causes craving and makes it a lot harder for the addict to stop. In Olds and Milner’s later experiments, they allowed the rats to press a particular lever to arouse themselves, to the effect that they would press it as much as seven-hundred times per hour. This region soon came to be known as the "pleasure center". Using drugs and alcohol stimulates the pleasure center in the brain that makes your brain think, “feels good- want more“. This can make it increasingly harder for an addict to stop using, until they hit a point called “rock bottom”. This is where choice comes back into play.

It is believed that certain individuals are predisposed or vulnerable to addiction based on biological, psychological and social influences. The euphoric high produced by many addictive substances is the result of overstimulation of the “pleasure center” of the brain. This is the same area that controls emotions, fear, self-control and overall feelings of wellness. The presence of these foreign chemicals creates a response that the brain will crave as soon as it fades. The brain’s chemistry works against its own health, as it rewires its decision making faculties around the primary goal of finding and taking more of the drug” (1). Many people mistakenly believe that psychological addiction is somehow less serious or real than physical addiction. The psychological aspects of addiction are much more challenging to repair and recover from than the physical addiction. Psychological addiction can last for years or even a lifetime.

This research paper will evaluate the biological aspects of addictive substance or behavior and how it affects the brain and organs. Biological aspects include dopamine levels that are replaced in the brain due to the reward system being overtaken and the absorption rate of the drug once it is ingested will be discussed. The biological aspects are extensive and permanent if the individual does not get the help they need. Furthermore the clinical issues of addictive substance or behavior will be discussed along with medical treatments and ethical issues. This includes treatments such as counseling

Addiction is defined as a chronic brain disease that is characterized by compulsive drug seeking and use, despite harmful consequences. In my opinion, compulsive drug use is a hallmark of addiction, yet a mechanistic understanding of this process has been elusive. Drug use is initiated primarily to obtain the excitatory actions of addictive drugs on brain reward systems. The reward pathway evolved to promote activities that are essential to the survival of the human race as well as other mammals (Bailey 2004). When stimulated by drugs of abuse, addiction often occurs especially in those who are genetically or otherwise “neurochemically” vulnerable

This research paper is a compilation of information gathered during lectures and through the web on the Nervous System and the Reward Pathway. This paper examines the structure of these systems, their discovery and the effects that drugs have on influencing these systems and how addictions are formed.

“Can Neuroscience Improve Addiction Treatment and Policies?” is a research that focus in the causes and effects of drugs in the brain. There is not explanation or analyses in the probable social and cultural causes and effects for using a drug.

Over the last few days at Providence Crosstown Clinic, I have gained a tremendous amount of insight into the field of addiction and substance use disorder. Crosstown Clinic is an addictions treatment clinic with an interdisciplinary team that cares for over seventy clients with substance-use disorder. Clients come into the clinic three times a day and are given either DEM (diacetylmorphine) or HME (hydromorphine). DEM is an addictive drug derived from opium that produces an intense euphoria, also known as “high”; whereas, hydromorphone is a synthetic narcotic analgesic, similar to morphine and heroin. During the first few days, I have learned Crosstown clinic began as a study to assess long-term opioid medications effectiveness, also known as the SALOME trail, to test whether hydromorphone, a licensed medication, is as good as diacetylmorphine, the active ingredient of heroin, at assisting people who suffer from chronic opioid addiction and who are not benefiting sufficiently from other treatments. I was told by the clinic nurse that the test found that hydromorphone is almost the same as DEM; however, clients prefer DEM better since it gives them a longer “high”. I have yet to work with clients with substance use disorder, and I am excited to learn more about alcohol and substance use like alcohol, marijuana, cocaine, and amphetamines.

While the choice to use alcohol and drugs is initially voluntary, alcohol and/or drug addiction arises because the normal functioning of the brain is impaired so that alcoholism and drug addiction become a “chronic relapsing disease of the brain” (National Institute of Drug Abuse, Drugs, Brains and Behavior. The Science of Addiction. 2014, 5). Drugs impact the pathways of the brain by flooding the circuit with dopamine, which disturbs and distorts normal communication between the brain’s neurons. Dopamine is a neurotransmitter present in regions of the brain which regulates movement, emotion, motivation and feelings of pleasure. Over stimulating the system with drugs produces euphoric effects which strongly reinforce the behavior of drug use teaching the user to repeat drug use. Continuing alcohol and drug use despite the adverse consequences of such use results in abusers experiencing some or all of the following symptoms: mental stress, impulsive behavior, anger, disorganized thinking, poor coping skills, inadequate decision making and inflexible cognitive response patterns.

Addiction is like all behaviours “the business of the brain”. Addictions are compulsive physical and psychological needs from habit-forming sustenances like nicotine, alcohol, and drugs. Being occupied with or involved in such activities, leads a person who uses them again and again to become tolerant and dependent eventually experiencing withdrawal. (Molintas, 2006).

This first video called, The Mechanisms of Drug Addiction in the Brain (Alila Medical Media, 2014), was a very informative video of the brain structure. It showed us how different drugs react in our brain and showed us a great visual of how these drugs interact and lead to more production of dopamine (e.g. over stimulation of dopamine levels leading to euphoria/good feelings). The video explains this process as, the major reward pathways involved in the transmission of the neurotransmitter dopamine from the ventral tegmental area – the VTA - of the midbrain to the limbic system and the frontal cortex (Alila Medical Media, 2014). The text also explained this process as directly or indirectly targeting the brain’s rewards system by releasing

The release of Dopamine in nucleus accumbens (NAs) via mesolimbic pathway mediate a positive reinforcing phase that is critical for the development of addiction. For this reason, one might deduce that addiction would no longer exist if a scientist were to create a way to block the dopamine-reward neural basis of addiction. However, elimination of addiction is more complex than that as it requires treatment of its the neurological, psychological, genetic, and environmental components.

Though the effect it gives to the user is quite desirable, cocaine creates a psychological dependence – which leads to the heightened tolerance for the substance. Tolerance means the user will eventually need more and more of the drug in order to get the desired effects cocaine produces. This fits the second classification of addiction according to American Psychiatric Association’s definition for what addiction is; loss of control in limiting intake (Farrenkopf, 2008). Since the amount of dopamine receptors are greatly reduced after prolonged substance abuse, the dopamine receptors become less and less responsive to the stimuli created by dopamine naturally released in the body. Only cocaine can give the user the pleasurable euphoric effect at this point. This is not the only negative neurological outcome from cocaine. The use of cocaine affects memory and recollection in the limbic system, specifically the amygdala and hippocampus (Kreek, Levran, Reed, Schlussman, Zhou & Butellman, 2012 ). Whenever a person undergoes an extreme high, the regions in the brain previously mentioned, associates the place, person, or

The complexity of the human brain creates mystery when determining the influence of neurophysiological factors and their role in the process of addiction. There is a proposed relationship between drug addiction and the mesolimbic dopamine system, with the mesolimbic pathway from the ventral tegmental area to the nucleus accumbens considered the ‘reward centre’ of the human brain (Alcohol Rehab, 2011). A release of dopamine is necessary for ‘reward’ which is hypothesised to initiate the addiction cycle by providing positive reinforcement for drug self-administration (Feltenstein & See, 2009). Methamphetamine triggers the release of dopamine from synaptic vesicles which flood the synaptic cleft activating feelings of euphoria, well-being

“Addiction is a brain disease expressed in the form of compulsive behavior,” says by Alan Leshner in his article, “Addiction Is a Brain Disease” featured in the book Drug Abuse: Opposing Viewpoints. Addiction has a variety of meanings depending on what your viewpoint of addiction. According to dictionary.com, the concrete definition of the word addiction is, “the state of being enslaved to a habit or practice or to something that is psychologically or physically habit-forming, as narcotics, to such an extent that its cessation causes severe trauma.” Basically various doctors and therapist consider addiction to be a genetic disorder. “Provocative, controversial, unquestionably incomplete, the dopamine hypothesis provides a basic framework