Invasive Lobular Carcinoma Essay

The N category describes whether or not the cancer has spread into nearby lymph nodes.

Over the past decade breast cancer has become one of the most predominant diseases in the United States. Breast cancer starts out as a malignant tumor in the tissues of the breast which is formed from the uncontrolled growth of abnormal breast cells. Breast cancer is the most common cancer in women, but it can also appear in men. (Stephan, 2010)

Over the past two decades, mammography has become the central tool used to detect cancerous regions within the breast. This evolution has been enabled by advancements in the technology itself and its implementation into healthcare regulations of numerous countries around the world (Pisano et al., 2004). In its beginning stages, breast cancer is a relatively treatable disease, and increased awareness for both mammograms and self-breast examinations have led to earlier diagnoses. Studies suggest that increases in mammography screenings have been one of the main reasons that breast

Despite significant advances in research, Breast Cancer is still the most common cancer, affecting both men and especially women. In the US, 232, 670 new cases of invasive breast cancer were expected to be diagnosed along 62,570 new cases of non-invasive breast cancer in women and about 2,360 new cases of invasive breast cancer were expected to be diagnosed in men in just 2014 .

N-cadherin is a protein encoded by the CDH2 gene. It interacts with the cellular cytoskeleton, and is often involved in cardiac muscle, as well as certain cancers. Being calcium dependent, it helps to maintain cellular structure and integrity. For example, it plays a role in trans-endothelial migration, which involves cell-cell adhesion [3]. The endothelial layer contains many different fibers, as well as pathways that allow attachment for the cadherin protein. Some cancer cells can eventually pass through the endothelium, causing the cancer to become malignant and spread. Cadherins in this case can be used to identify and track the spread of the cells, and further identify common routes of travel through the human vasculature.

It was Monday March 17th, 2014 when I received a phone call from my grandma asking me to come visit her. That day is the day when I received the news that my grandma has been diagnosed with invasive lobular carcinoma breast cancer. My grandma and I are very close. Her diagnosis is what persuaded me to write my I- search paper on this specific breast cancer. One topic I am really focusing on when I write my paper is the genetic factors because its important to my family and I. Even though I began to research about the cancer when my grandma was diagnosed, there are still a lot of things I don’t know about and I’m interested to learn about within creating this paper. In this paper I will share with you the importance of invasive lobular

I regularly speak for my parents with insurance companies, utilities representatives, and doctors. It is an important role. Their English comprehension even after 20 years in the U.S. remains inadequate for these circumstances. Because I was born here and speak English well, it falls to me to be the speaker for the household. I enjoy the calm I can bring to my parents when I help this way. But juggling school responsibilities with the doctors’ visits, phone calls, and other appointments can be stressful.

Tumor profiling is another form of advancement to help cure breast cancer. Tumor profiling allows researchers to better understand the genes in cancer cells. In this article found on the Susan G. Koman website, the ability to profile thousands of genes found in tumors is helpful in determining how likely breast cancer will reoccur and probable treatment. “The gene profiles of some tumors may help predict whether the cancer is more likely to recur and metastasize. Tumors with gene profiles showing a high risk of breast cancer recurrence or metastasis may be more likely to benefit from chemotherapy than tumors with gene profiles showing a low risk” (Susan G. Koman).

- The TNM classification is to describe the seriousness and characteristics of a patient’s cancer. T describes the measurements of the tumor. N stands for whether or not the cancer has started to develop in the lymph nodes. M is used for to determine if the cancer has moved from the original site to another location.

The term fibrocystic breast disease is used to describe the benign condition that may have caused Ms. Barker's breast mass. Whether a mass is solid or cystic, a benign mass is usually three-dimensional, mobile and smooth. Borders to the mass are not irregular (Sharma, Dave, Sanadya, Sharma & Sharma, 2010). Ms. Barker has lobular hyperplasia. Furthermore, abnormal cells can increase complexity when they grow inside the lobules of the the breast but do not spread or metastasize (McCance & Huether, 2014). This condition is known as lobular carcinoma in situ (LCIS). Although LCIS is not invasive cancer, it increases the risk of getting invasive breast cancer in either breast (Types of breast cancers, 2016). Often around menses women develop fibrocystic breasts. There are often lumps noted that quickly disappear with menses, however in lobular fibrocystic breast disease lumps are found in the milk producing glands. Breast cysts are common with approximately over 1/3 of the women 35-50 having cysts (Breast lumps, 2016).

Oral cancer is a devastating disease. Over eight thousand American lives are taken by oral cancer and only a fourth of these patients do not excessively drink alcohol or smoke tobacco, which are the two main causes of oral cancer (The Oral Cancer Foundation). Survival rates for oral cancer could be much higher if the population would take precautionary measures to reduce their chances of being diagnosed with oral cancer. When the use of alcohol and tobacco are decreased, the chances of acquiring oral cancer are also decreased. By visiting the dentist at least once every year, new lesions could be found. Unfortunately, only seven percent of the population, who visits the dentist regularly, receives a thorough oral cancer exam(The Oral

Sentinel nodes are lymph nodes that receive the bodies waste first (Craft, Gordon & Tiziani, 2011). It is believed that the cancer cells are metastasised to these nodes before spreading to other nodes of the body (Craft, Gordon & Tiziani, 2011). To identify these nodes, dye or a radioactive tracer is used to locate the node and determine an accurate stage of cancer (Craft, Gordon & Tiziani, 2011).

IDC is a ductal breast cancer because it developed in the ducts. When you have a physical exam and a mammogram and they show signs of IDC you’ll have a biopsy to collect cells to be analyzed. The doctor will be able to make a diagnosis by the results.

This ability of malign cancer to make their way across basement membrane and into blood vessels is what makes cancer so fatal and impossible to be cure by surgery alone. The result of metastasis and invasion in normal tissue by cancer cells are often seen as one of the distinctive features of malignancy (Ruoslahti 1996). Even though the ability of invasion and metastasis are one of the hallmarks for cancer, these abilities are not unique to cancer cells as it can also occur during the early development stage of the embryo, in healthy organisms and in many noncancerous diseases (Mareel & Leroy 2003). It does not matter whenever the organism has developed benign or malign cancer, all cancer cells have the ability to disturb the normal cell cycle and threaten the survival of the organism.

Salivary gland tumors are a morphologically diverse group of neoplasms, which may present considerable diagnostic and management challenges for the pathologist and surgeon. Salivary gland tumors are rare with an overall incidence in the western world of about 2.5 to 3.0 per 100,000 per year. About 80% of all lesions are benign; hence salivary malignancies are particularly rare, comprising less than 0.5% of all malignancies and about 5% of cancers in the head and neck. (1)