Invitro and Insilico Anti-angiogenesis of Plant

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Most of the drugs available today are from plant origin, which can avoid not only side effects but also multiple steps in the synthesis of chemical compounds. It is the oldest form of health care known to mankind which is reported in herbal pharmacopoeia. Along the lines, we have identified that one of the Sophora family members (Sophora flavescens) has shown to arrest the cell cycle and inhibit the angiogenesis by down regulating the expression of VEGF. Sophora family members are distributed across the world and they showed to have many pharmacological actions. To identify and characterize the antiangiogenic compounds present in the Sophora family members, we have collected S. interrupta, from the Tirumala hilltop areas of Tirupati, Eastern Ghats, Andhra Pradesh, India. The roots of this plant are crushed into a fine powder and the presence/absence of phytochemical constituents in various solvent phases was validated. Results showed that SEA extract are not only positive for terpenoids and alkaloids but also showed significant anti-oxidant and anti-inflammatory activity. Antioxidant and anti-inflammatory potential of phytoconstituents has shown to reduce the risk of blood vessel associated cancer. It suggests that the compounds present in the SEA extract can serve as a powerful physiological effects that make them useful as phytomedicine. However, there is no such secondary metabolites from S. interrupta or their allied species are documented. In search of antiangiogenic
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