Invitro and Insilico Anti-angiogenesis of Plant

The earth’s tropical forests are major contributors to the treatment of diseases and the relief of suffering. Covering only 6% of the Earth's surface, tropical moist forests contain at least half of all species. Rainforest plants are the source of compounds useful for medicinal purposes. The abundant plant resources of tropical forests have already provided solid medical advances, yet only 1% of the known plant species have been thoroughly examined for their medicinal potentials. 70% of the 3000 plants identified by the United States National Cancer Institute as having potential anti-cancer properties are endemic to the rainforest.

It is now believed that nature has given the cure of every disease through herbal medicine or management. Plants have been known to relieve various diseases in Ayurveda. Consequently, the researchers today are emphasizing on evaluation and characterization of various plants and plant constituents against a number of diseases based on their traditional claims of the plants given in Ayurveda. Extraction of the bioactive plant constituents has always been a challenging task for the researchers

The use of natural products as medicine has initiated the isolation of active compounds. The first commercial pure natural product introduced for therapeutic use is generally considered to be

Licorice root is used worldwide as a natural sweetener, as well as a flavoring agent. The main composition of plant Flavonoids and Isoflavonoids act as inhibition platelet aggregation, and anticancer, antioxidant (20). Aly et al.,2005(21) indicate that liqurice have potent anti-inflammatory reduction edema about 78.3 while diclofen about 73.9% also have anti-ulcerogenic activity associated with a reduced acid output and an increased mucin secretion, an increase in prostaglandin E2 release and a decrease in leukotrienes (22). Many volatile oil and vitamins such as B1,B2,B3,B6,C,E, Biotin, Foli acid, Pantothenic acid act as expectorant, laxative, liquiritin act as antitussive (23). Also contain Coumarins Herniarin and umbelliferone (24).moreover plant used for treatment of asthma , chronic fatigue, hormonal disturbance , antiviral, antibacterial , hepatoprotective, anti-oxidant , antiulcer, ant mutagenic, Hypothermic antioxidant, anti-inflammatory, relieve pain , expectorant, hypoglycemia,

Panax notoginseng, a root of Panax notoginseng (Burk.) F.H. Chen, has been traditionally used as either functional food or herbal medicine. Previous studies show that Panax notoginseng is used in cardiovascular disease, cerebrovascular diseases, diabetes, pains, and bleeding (Ng, 2006; Wang et al., 2009; Yang et al., 2014). In cancer prevent and therapy research, Panax notoginseng is beneficial to the prevention and treatment on colon, liver and breast cancer (Chen et al., 2006; Wang et al., 2007; Toh et al., 2011; He et al., 2012; Wang et al., 2009; Wang et al., 2012 ). Although, Chen et al. (2006) have been show that Panax notoginseng can suppress liver metastasis of C57BL/6 mice. And, a ginsenoside from Panax notoginseng, 20(S)-25-methoxyldammarane-3b,

Traditionally, the root of A. racemosus has been widely used to increase fertility and libido, cures inflammation of sexual organs, enhances ovulation, prepares the womb for conception and prevents miscarriages (Kalia et al., 2003; Naik, 1988; Dwivedi & Tewari, 1991). Although, A. racemosus roots also known to possess estrogenic property (Tewari et al., 1968), but it has also been documented that at higher doses of A. racemosus, it maintains the balance between the endogenous female sex hormones (Sharma and Bhatnagar, 2011). Moreover, the ethno medical use of A. racemosus root as an anticonvulsant has been experimentally validated in our laboratory (unpublished data) as well as by other researchers too (references). The available literature reveals that the plant has not been explored with respect to its therapeutic potential as an anticonvulsant in catamenial epilepsy. But nowadays the virtual screening of the phytochemicals is believed to be a major tool for drug discovery beyond their ethnic use. Hence, an effort has been made to explore the pharmacological activities of Asparagus racemosus root using Prediction of Activity Spectra for Substances (PASS) and Pharmaexpert. In line with in our current study, a PASS based analysis (Table 1 & 2) revealed the presence of different bioactive phytoconstituents which might be responsible as an anticonvulsant with the most significant possibility of getting effective in the management of catamenial

The study of cancer has impact millions of lives and scientist have continued to research new treatments for this disease. Scientists are coming close to developing a cure for this disease. New compounds are being tested to develop this cure. Compounds used in this research are Onosma echioides L., German Chamomile (Chamomilla recutita), and Rosemary (Rosmarinus officinalis L). Onosma L. is a medicinal plant traditionally used as laxative, anthelmintic and for alexipharmic effect. Chamomile have many medicinal attributes, used for hay fever, inflammation, muscle spasms, menstrual disorder, insomnia, ulcers, wounds, gastrointestinal disorder, rheumatic pain and hemorrhoids. Rosemary is a medicinal plant, a good source of iron, calcium,

It is the oldest and still extensively used in many parts of the world today. Herbal medicines played an important role in maintaining the human health for thousands of years, and have gained growing popularity and extensive usage in the world over the last decades5. Using plants as medicine provides remarkable advantages for treating many conditions5. Different parts of the plant provides certain therapeutic effects therefore, it can be used to treat many different diseases. They are usually sold as tablets, capsules, powders, teas, or even as dried plants6. Pharmaceutical drugs contain specific active constituents, while herbal medicines contain relatively unprocessed mixtures of phytochemical constituents and their holistic efficacy is usually produced by the unresolved integrative effects between the constituents

The antioxidant and tumor inhibiting property of Brahmi were studied in 3- methylcholanthrene induced fibrosarcoma rats (Rohini et al., 2004). The levels of the antioxidant enzymes such as glutathione peroxidase, superoxide dismutase, catalase and glutathione, the rate of lipid peroxidation (LPO) were determined in the liver and kidney tissues. Sarcoma induction in rats resulted in a marked increase in the rate of LPO and a decrease in the antioxidant enzyme status. Furthermore, tumor markers such as lactate dehydrogenase, alanine transaminase, aspartate transaminase, creatine kinase, and sialic acid showed an upregulated expression in the serum. Brahmi supplementation enhanced the antioxidant enzyme status, reduced the rate of lipid peroxidation and downregulated tumor development markers. Among the five crude samples such as the whole plant of Bacopa monniera (L.)Wettst and four different fractions (petroleum ether, CHCl3, EtOAc, and n-BuOH fractions) of the methanol extract, n-BuOH fraction was noted to have the highest antitumor activity as per bioassay-guided methods conducted by Peng et al. The dammarane triterpene saponins isolated from n-BuOH fraction, bacopaside É (1) and bacopaside VII (3), had

Furthermore, inhibition of ROS protects TJs against disruption during brain damage (8). Furthermore, amelioration of ischemia-induced BBB disruption and brain edema in addition has been shown by using diet antioxidants such as olive leaf extract and ginkgo biloba extract (9, 10). Matricaria chamomilla can be an aroma herb with anticancer, antioxidant, and anti inflammatory properties (11), is an important source of dietary antioxidants (12). Various studies show that matricaria chamomilla is associated with several health advantages such as antioxidants (13), and cancer (14). However, to the best of our knowledge, little is well known about the result of matricaria chamomilla extract on BBB dysfunction during brain ischemia. In the present study, we looked into whether matricaria chamomilla extract has beneficial results on brain ischemia-induced edema and BBB dysfunction in mice. The possible root systems are also looked into, especially those from the antioxidant ramifications of the matricaria chamomilla

Results from Molinspiration: With the help of ‘Canonical SMILES’ of phytochemicals taken from PubChem, virtual screening was performed. All the phytochemicals which followed the Lipinski’s rule of five were shortlisted, as shown in Table.9

The plant kingdom is abundant in species that act as anti-inflammatories to animal tissue. If the premise is accepted that through an ecological integration most of the biological needs of humanity and the other animals are met by our evolutionary environment, the wealth of anti-inflammatory herbs comes as no surprise. Whilst they are rarely as immediately powerful as the steroid drugs, they are very rarely as dangerous and potentially life threatening.

Both crude and processed aloe vera was shown to increase average life span of Fischer 344 rats by 10%. Group 2 and 3 had a lower incidence of atrial thrombosis than than the control group 1. Moreover, Group 2 has a significantly lower occurence of fatal chronic nephropathy and of multiple causes of death in comparision to the control group 1. Moreover, no adverse, toxic effects were found with the ingestion of aloe vera.

Herbal medicines are great alternative for commercially manufactured medicines available in the market. The major reason why herbal medicine differ from modern medicine is because they are produced with 100% natural content. Therefore the plant extract has all the medicinal values that are as effective as modern medicine. Commercially prepared drugs show results quickly but have numerous side effects. However herbal medicines don’t show any side

There are some evidences that supports that particular herbal treatments help relieve the symptoms of cancer and could prevent the cured cancer from coming back. Herbal medicinal treatments lessen the pain being experienced by a cancer patient. The powerful extracts of herbs helps in strengthening the human body’s immune system, which results to the prevention of cancer from coming back. According to the Cancer Research UK, researchers in China in October 2007 looked at a range of studies of herbal medicine for many medical conditions, including chemotherapy side effects. They found that some standard herbal medicines could be