Is A As Effective As Clopidogrel For The Patient With Acute Coronary Syndrome?

994 WordsNov 15, 20154 Pages
Is prasugrel as effective as clopidogrel for the patient with acute coronary syndrome? Acute coronary syndrome (ACS) is the most common form of cardiovascular disease.1 In 2006, about 733,000 ACS patients were discharged from hospitals costing the United States $150 billion annually.2 Eighty percent of these cases were either unstable angina (UA) or no ST- elevation myocardial infarction (NSTEMI), and the remaining 20% were ST-elevation myocardial infarction (STEMI). The pathophysiology of ACS includes the stable plaque forms get converted into unstable plaque forms.2 These unstable plaque forms have numerous thin fibrous cap cells, inflammatory cells, activated macrophages, and smooth muscle cells. Sympathetic activity increases myocardial contractility, pulse rate, blood pressure, and coronary blood flow which leads to plaque rupture or fissure. As the artery ruptures, it causes thrombus formation and ischemia in this particular artery. Depending on the condition, different thrombi could form. The unstable angina forms a small thrombus formation, NSTEMI forms a partial thrombus formation, and STEMI forms a complete and persistent thrombus. The risk factors involved in ACS are age, physical inactivity, and history of hypertension, diabetes, or angina. The signs of acute coronary syndromes are an acute heart failure, tachycardia, bradycardia, or heart blockage, and the symptoms of ACS consist of chest pain, pain in the extremities, nausea, shortness of breath, heavy
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