Is Genomics Comparative And Functional Genomics?

768 WordsMay 9, 20164 Pages
Question #4 (2 Points) What is genomics? Genomics is the study of similarities and differences in genomes between living organisms, either between or within species, using experimental methods derived from the acquisition of entire genomes due to quicker and cost effect sequencing. There are two approaches to studying genomics comparative and functional genomics. Comparative genomics gives insight to the function of genes by comparing sequences to each other. This process can be done on single genes across species, a chromosomal region or even entire genomes across species. Similar sequences can then be compared across species to give an idea of gene conservation through evolution and its function can be inferred. This method nowadays uses genome annotation to identify genes and regulatory elements within stretches of DNA by computer. Genome annotation is a process of mapping genetic elements such as promoter elements, protein-coding regions, splice sites, and transposons to certain areas in the genome. Comparing these annotations within species allows for the prediction of gene and regulatory element locations are in the genome. The counterpart of comparative genomics is functional genomics in which genetic, molecular, biomolecular, and cytological experiments are used to confirm functions predicted by the computer sequence analysis and with the availability of whole genomes, assay can be used at a genome wide level as opposed to single genes. This information
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