Schizophrenia is a class of mental disorders often symptomatic of a broad spectrum of behaviours which ultimately fail to determine what is real. Some of the symptoms that make up the spectrum of schizophrenia include hallucinations, invalid or illogical beliefs or thought processes, and abnormal social expression. It is worth noting that schizophrenia does not mean multiple personality disorder but rather a separating of mental function and is also rarely diagnosed separately but along with other conditions, such as depression, mania, and anxiety disorders. As to the causes of schizophrenia, both genetic [1] and environmental factors [2] have been found to influence the progress of schizophrenia, but there is still much which is unknown …show more content…
counselling) and antipsychotics. Antipsychotics do not cure the subject of their psychosis but merely treat the positive symptoms by mainly blocking the dopamine receptors in the brain. Hence, new drugs and treatments are continuously in the pipeline to find a drug that manages the symptoms of schizophrenia with relatively few (preferably none) side-effects.
Antipsychotic drugs are classified as either typical or atypical, based on their relative potency and side-effects. This classification is usually substituted with referring to typical as first generation and atypical as second generation, due to atypicals comparatively safer side-effects. However, it has been argued that due to the severe side-effects of both, the amount individual variation between psychotic patients, the patient’s tolerance to individual drugs, and the fact that antipsychotics treat symptoms rather than the psychosis, it might be better to class the drugs in regards to their mechanisms rather than their relative potencies [6][7]. Typical antipsychotics antagonise the D2 receptors and atypical antipsychotics target the D2 receptors among others (e.g. D3 and 5HT2 receptors).
Currently, the main drugs used to treat schizophrenia include clozapine, risperidone and haloperidol. It is still debatable which class, as stated above, whether typical or atypical antipsychotics are better and produce relatively safer side-effects among
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Get AccessSchizophrenia is a mental health condition that is the base of several psychological symptoms. There are many people out there who suffer from this disorder and have no idea on how to cure it. Some people tend to spend their whole life with this disorder; whilst others get it treated as soon as they see first sign or symptom of it. Schizophrenia is not a disorder that cannot be treated; with the right kind of treatment, the disorder can be controlled and the individual suffering from it can be cured. The paper will discuss the schizophrenia disorder in detail, causes, risk, signs & symptoms, and treatments of it.
Researchers believe that dopamine plays an important part in schizophrenia. The goal of conventional antipsychotic drug therapy is to reduce the amount of dopamine, or the amount of dopamine receptor sites. They are dopamine antagonists
According to NAMI (), schizophrenia is a long term mental illness that interferes with a person’s ability to think clearly, make decisions, and relate to others, impairing a person from functioning to their full potential when left untreated. For these persons affected, it is many times difficult to distinguish what is real from what is not. “Unfortunately, no single simple course of treatment exists.” Research has linked schizophrenia to a multitude of possible causes” (NAMI).
There is no known or possible cure for schizophrenia. This was the worse news that has been given yet. I have been switching between different medications and dosages to help my symptoms for years. I was happy to hear that in the 1990s, new antipsychotic medications were developed (S.A. Roberts, Personal Communication, March 15, 2016). These new medications are called second-generation or atypical antipsychotics (Schizophrenia. n.d.). These medications were offered to me in the form of a pill and an injection that can be given once or twice a month. Other than medications, I have also been offered therapy. There are different kinds for different aspects. Personally, I have been receiving psychosocial treatments and cognitive behavioral
The introduction of Clozapine, marked a turning point in the treatment of schizophrenia, as the first "atypical" antipsychotic drug lacking the propensity to produce ‘extra-pyramidal symptoms’ (associated with the older antipsychotic agents) (Kane et al. 1988). Even though, Clozapine has not conclusively demonstrated its significantly superior record or efficacy for psychosis (Gardner et al. 2005), it has proven exceptional effectiveness, compared to other more traditional antipsychotics (Claghorn et al. 1987). However, Kane et al. (1988) and others have concluded, 30–60% of all schizophrenic patients who fail to respond to typical antipsychotics may respond therapeutically/effectively to Clozapine (Breier et al. (1994) & Iqbal et al. (2003)). This is especially apparent for refractory schizophrenia (Kane et al. 1988), treatment-resistant schizoaffective disorders (Zarate et al. 1995) and aggression (Cohen & Underwood, 1994).
Medications for schizophrenia can cause rare side effects but the side effects can be serious. Because of the side effect many people are unwilling to take the medication. Antipsychotic medications are the most generally prescribed drugs to treat schizophrenia. They help control the symptoms of schizophrenia by disturbing the brain neurotransmitters dopamine and serotonin.
Antipsychotics: Olanzapine (Zyprexa), Risperidone (Risperdal), Quetiapine (Seroquel), Ariprazoe (Abilify), Ziprasidone (Geodon), Lurasidone (Latuda), Asenapine (Saphris)
Treatment for Schizophrenia can be classified under two categories medication and Psychosocial. Medication is the main form of treatment for Schizophrenia. Anti-psychotics are used as medicinal treatment for Schizophrenia patients Types of
Antipsychotics are primarily used to manage the symptoms of psychosis, particularly schizophrenia and bipolar disorder by blocking D2 receptors in the dopamine pathway of the brain. There are two main types of antipsychotics; typical antipsychotics, also known as the first generation antipsychotics (FGA) which were developed in 1950s, example of medicine in this category include Chloropromazine, Haloperidol, Flupenthixol, and Loxapine. Atypical antipsychotics, also referred as second generational antipsychotics (SGA) which acts as an antagonist for 5HT2A receptor aside from its blocking effect on D2 receptor, drugs in this class include Olanzapine, Quetiapine, Risperidone, Clozapine and Aripiprazole.
Schizophrenia is a life-long disorder that affects about one percent of the population (Mueser & McGurk, 2004). The cause of this mental illness is still unclear. Studies have suggested that Schizophrenia does not arise from one factor but from a combination of genetic, environmental, and social factors (Liddle, 1987). People diagnosed with Schizophrenia struggle to deal with a multitude of symptoms that make it difficult to function (Mueser & McGurk, 2004). Antipsychotic medications are a popular treatment of the symptoms of Schizophrenia (Mueser & McGurk, 2004). Research is constantly being done to develop these medications to enhance the quality of life of those diagnosed with Schizophrenia.
Because schizophrenia manifests itself as a blend of a thought disorder, a mood disorder, and an anxiety disorder, a mixture of antipsychotic, antidepressant, and antianxiety medication is used to treat it. One main type of antipsychotic medication is traditional, such as chlorpromazine, haloperidol, and fluphenazine. These medications have been present since the 1950 's, and they are most effective for treating positive symptoms because they block the dopamine receptors. Dopamine is a neurotransmitter that aids in regulating mood and behavior. Schizophrenia is believed to be caused by an excess of dopamine related activity in the brain. By blocking the receptors, the disorder is controlled.
When it comes to treatment for schizophrenia, there are many different antipsychotic medications that can be administered to patients.
Since schizophrenia may not be a single condition and its caused are still unknown, current treatment methods are based on both clinical research and experience. These approaches are chosen on the basis of their ability to reduce the symptoms of schizophrenia and to lessen the chances that symptoms will return. Antipsychotic medications reduce the risk of future psychotic episode in-patients who have recovered from an acute episode. Even with continued drug treatment, some people who have recovered will suffer relapses. Far higher rates are seen when medication in discontinued. In most cases; it would not be accurate to say that continued drug treatment "prevents" relapses; rather it reduces their intensity and frequency. The treatment of severe psychotic symptom reappear on a lower dosage, a temporary increase in dosage may prevent a full-blown relapse. (http://nimh.nih.gov/publicat/schizoph.htm), National Institute of Mental Health
Schizophrenia treatment has developed to have two specific classes of drugs, typical antipsychotics and atypical antipsychotics. Typical antipsychotics were the first type of drugs to be used on schizophrenia patients. They are also known as the ‘first-generation’ drugs. Atypical antipsychotics, or ‘second-generation’ drugs are newer drugs that are now often used in replacement of the ‘first-generation’ drugs. However this progression of drug treatment for schizophrenia patients has shown little change in effectiveness as studies were unable to find distinct difference. The only real difference between the two can be seen in their prices and side effects. Although, the typical antipsychotics have now tapped into the fast-growing generic drug
Treatment of schizophrenia may vary according to what clinicians believe to be its causes. For example, some believe (and this is backed by evidence) that the condition is caused by over activity of the dopamine system, so that the person experiences too much stimulation. Dopamine is a neurotransmitter, so that in effect too much activity is occurring in the brain. Clinicians who believe this is the case are likely to use drug therapies to correct this over activity, and will use antipsychotic drugs.