Ischemic Stroke Effect

There are two major branches of strokes: those caused by narrowing or blockage of the arteries leading towards the brain, and those caused by blood vessel leaking or rupturing in the brain. Ischemic strokes account for approximately 87% of Stroke cases, which reduces the blood flow to the brain. About half of the Ischemic strokes are caused by clotting in small or large arteries, a smaller portion are caused by

Ischemic stroke is the blockage of blood vessels in the brain as a result of blood clots (thrombi), causing the portions of the brain nourished by the vessel and its tributaries to be starved of nutrients, poisoned, and to eventually die (“Symptoms

Ischaemic stroke is a serious neurological condition in which a blood clot stops blood flow to the brain and for which immediate action is required. It is the fourth cause of death in Western society, causing 87% of all strokes, and also results in long-term disability among survivors (Bunevicius et al., 2013). In the United States, about 800,000 strokes occur each year, and approximately six million Americans are living with neurological deficits caused by ischaemic strokes (Duong, 2012). Therefore, neuroradiological imaging has become a major section in radiology departments.

As mentioned above, strokes are pathophysiological changes. Ischemia which accounts for 87% of all strokes is a decrease or absent circulating blood which deprives neurons of necessary substrates. As there is no storage of glucose in the brain it leaves no opportunity for the chief ingredient for energy substrate and is incapable of anaerobic metabolism (Shah, MD, n.d.). Ischemia is a medical condition diagnosed when tissues do not have a sufficient oxygen supply, therefor resulting in a decrease in ATP energy, leading to necrosis of tissue. Decreased oxygen supply to tissue (ischemia) is caused by a blockage in an artery mainly from an embolism. An embolism is the breakage of an atherosclerosis formed in any coronary arteries. This floats freely in the blood stream, which eventually may plug a major artery in the brain (stroke), heart (MI) or lungs (lung failure). A thrombus occurs when an already

Cerebrovascular accidents, or strokes, will lead to brain damage that affects the functioning of executive function, memory, language, visuospatial performance and emotional states. Corresponding vertebral arteries and carotid arteries provide blood to the brain from the heart that the carotid arteries are internal and external sections of the thyroid cartilage. Where the optic nerve rests the internal artery distributes into the anterior and middle cerebral arteries. The vertebral arteries arise through the spinal vertebrae and meet the lower pons to form the basilar artery. The brain receives 15% to 20% of the oxygenated blood from the heart and can only endure fleeting interruptions of blood flow before neural operations

stroke is an acute episode of focal dysfunction of the brain, retina, or spinal cord lasting longer than 24 h, or of any duration if imaging (CT or MRI) or autopsy show focal infarction or haemorrhage relevant to the symptoms ,which is a leading cause of death and long term disability worldwide. It results from transient or permanent disruption of cerebral blood flow, leading to necrotic death of the brain tissue supplied by the affected artery. It activates an inflammatory condition in the affected area, marked by infiltration of inflammatory cells. Inflammation can induce an apoptotic cell death in the transition region between necrotic and normal tissue, so called penumbra, for a fairly prolonged period of time.[1].

Often times, doctors will typically call a stroke a “brain attack” because the events that transpire resemble those that occur during a heart attack (Wang and Aamodt, 2010). Blood supplies a constant source of oxygen to the brain. However, a stroke occurs when that blood supply to any given part of the brain is suddenly ceased. If the blood supply to the brain is suddenly interrupted this leads to the deprivation of oxygen and glucose to that area. The brain cells that are prevented from acquiring these substances, especially oxygen, will be quickly killed off. Strokes can be categorized into two classes: Ischemic and hemorrhagic strokes (Lindley, 2008).

Stroke, or brain attack, is the number four killer of adults in the world. In the United States, 160,000 deaths occur each year. From 1999 to 2009, the death rate from stroke gradually lowered as improvements to medicine and testing developed. Yet, 800,000 Americans continue to have strokes and survive the event. Worldwide, about 15 million experience stroke with 6 million who die and 5 million who become permanently disabled. (Robinson, Richard & Odle, Teresa G. & Frey, Rebecca J. & Odle, Teresa G. , 2011) The statistics in America are better for surviving a stroke because of rapid response and better interpretation of symptoms. Nevertheless, surviving a stroke often brings on dilapidating effects; which means a change in lifestyle and lifelong rehabilitation through physical therapy.

Effects - Every stroke is different, and each person that is affected by a stroke will suffer from different problems and have different needs. The way in which you are affected depends on where in the brain the stroke occurs and how big it is. A stroke on the right side of the brain generally causes problems to the left side of the body, and a stroke on the left side of the brain causes problems on the right. The brain is dived into several different areas which control different functions, including movement of the body, language, the way in which you think and senses (touch, sight, smell). Due to different arteries supplying blood to different areas of the brain, where abouts the brain is damaged determines which function is affected. Some strokes occur at the base of the brain which generally cause problems with breathing, moving and eating. These factors impact the effect of a stroke and the recovery after; Type of stroke, which area of the brain is damaged, how much tissue is permanently damaged and the person’s health and level of activity before a

An ischemic stroke is caused by a blood vessel that has been blocked (for example, by a clot), whereas a hemorrhagic stroke is caused by a vessel bursting and bleeding into the brain (Kolb & Whishaw, 2012, p. 45). Although both types of strokes result in the same ending - the brain not getting the fluids that it needs- they are caused by extremely different events. In addition, ischemic strokes are more common and typically less fatal. An estimated eighty to ninety percent of stroke suffering patients seen in hospitals have endured an ischemic stroke. For this reason, the primary treatment for all strokes is to give the individual a blood thinner. However, if an individual is suffering from a hemorrhagic stroke, this type of treatment will only make the situation worse, and likely lead to

Stroke is known as, “the death of nerve cells caused by an interruption of blood flow to a region of the brain,” (Goodenough, 138). When a section of the brain is shut off, neurons cannot receive enough oxygen and glucose that they need and die. The seriousness of the stroke depends on where the interruption of blood flow took place. The destruction of neurons in certain regions of the brain can cause the, “abilities controlled by that area of the brain such as memory and muscle control are lost,” (National Stroke Association). There

When possible, in-vitro testing on isolated organs and tissues is used, but due to the complexity of human anatomy and physiology, knowing the effects that this testing would have on the entire body is nearly impossible. The same goes for computer simulations, which are not yet advanced enough to represent human research. Luckily, humans share very similar cell and vital organ functions with other mammals, similarities that allow for research in animals to be applied affectively back to humanity. For example, the risk of sustaining permanent mental and physical impairment from a stroke has decreased through studies using rabbits. Strokes, in both rabbits and humans, are caused by blood clotting which prevents oxygen from reaching the brain. Introducing anti-clotting factors immediately after a stroke has been shown to lessen the permanent effects of strokes in rabbits, and is similarly effective in humans. (Society for Neuroscience 2012). In comparison to induced strokes in a population of rabbits, research on human subjects would be inefficient due to the

Cerebrovascular tissue undergoing ischemia has two layers , outer layer and inner layer. Inner core of severe ischemia with blood flow below ten to twenty-five percent, showing necrosis of both neuronal and supporting glial elements. Outer layer of less severe ischemia (penumbra),which supplied by collaterals and contain cells which can be retrieved by timely intervention.

According to the National Institute of Neurological Disorders and Stroke, a stroke is defined as “decreasing in blood supply to part of the brain is suddenly interrupted, or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding brain cells’’. When there is a blockage or rupture in the brain artery, the blood stream is cut off to the brain. In addition, that onset will affect the delivery of oxygen to the brain cell, which will have side effect on memory and muscle control. The people who had influenced by a stroke rely on where the stroke happened and the number of the harmed cell in brain. For instance, if someone has a stroke the left side effects the opposite side, the damage depend on the treatment when you received, and how much time since the onset of signs and symptoms. On other hand, people who have massive strokes may not survive from it or losing the ability to speak, feel, and walk. Some

A stroke caused by a blocked artery by a blood clot or bursting of a blood vessel because of uncontrolled high blood pressure. There are main three types of the stroke. An ischemic stroke occurs when a blood clot blocks one of the arteries which supply blood to brain. A clot may be caused by fatty deposits (plaque) that build up in arteries and cause reduced blood flow (atherosclerosis) or other artery conditions. (mayo clinic). About 89%, strokes are ischemic strokes. Ischemic stroke includes thrombotic stroke. A thrombotic stroke occurs when a thrombus stuck in one of the arteries that supply blood to the brain. A clot build-up of fatty deposits in arteries. Another type of stroke is called the hemorrhagic stroke. This stroke occurs when a blood vessel leaks or ruptures in the brain. A bold vessel leaks or ruptures from many conditions like uncontrolled high blood pressure or overtreatment with anticoagulants and the weak spot in blood vessel walls. (mayo). Some people experience a mini-stroke it is known as a transient ischemic attack (TIA). A temporary decrease or clot stuck in a vessel in our brain causes TIA. It happens less than five minutes. This stroke does not have any symptom, because the blockage is