In this work we aimed to highlight the use of ologen implant in cases of juvenile glaucoma. This group of glaucomas has a lower success rate than primary open angle glaucoma, and antimetabolites impose more complications. We also used one eye from each patient for MMC, and the other eye of the same patient for ologen. Doing so, we exposed the ocular tissues of the same patient to the 2 surgical modalities.
In this work, all the eyes had IOP above 21mmHg on maximally tolerated anti-glaucoma medications. The mean preoperative IOP was insignificantly different between the ologen group and MMC, while mean postoperative IOP was significantly lower in the MMC group on the first postoperative day (p=0.007), and at 1 week (p=0.039). At 1, 3 and 6 months, there was no significant difference between both groups, while 1 year postoperatively it was significantly lower in the ologen group (p=0.005). And there was a significant drop in mean IOP at each follow up period in each group (p<0.001).…show more content… Some of them have found that the techniques were comparable in IOP lowering effect. [6-9]
In 2015, Ji and colleagues conducted randomized clinical trials on trabeculectomy with Ologen implant compared to trabeculectomy with MMC for treatment of glaucoma. Ologen implant was associated with lower but non-significant percentage reduction in IOP. There was also no significant difference in the reduction in glaucoma medications, success rate, and incidence of complications.