Ketogenic Diet Research Paper

Glioblastoma (pronounced like gleO blastoma) is an incurable brain cancer,Survival rate is usually measured in months.This became a word that was instantly defined, researched, dissected, feared, and tried to comprehend and understand by family,friends and acquaintances of Larry McKee (McKee)who was personally affected from this single word, it was quickly added to their vocabulary, because of the of the events that transpired on October 22, 2011 that forever changed lives “Glioblastomas are tumors that arise from the astrocytes- the star-shaped cells that make up the “glue-like,” or supportive tissue of the brain. These tumors are usually highly malignant (cancerous) because the cells reproduce quickly and they are supported by a large network of blood vessels.”(A.B.T A..) He was diagnosed with stage four.

Glioblastoma is the most common and aggressive form of malignant brain cancer in adults. On average, 8 of every 100,000 people in the U.S. are diagnosed with glioblastoma every year – representing approximately 2% of all cancers diagnosed [1]. Glioblastoma tumors form when astrocytes, star-shaped cells which support and protect the brain, re-enter the cell cycle and start to rapidly divide. Because the brain is supported by a large network of blood vessels, tumors grow quickly and are difficult to remove surgically. Present treatments for glioblastoma are limited to surgery, radiation therapy, and chemotherapy; however, despite these interventions tumors are likely to regrow. Consequently, typical survival time following glioblastoma diagnosis is less than 2 years.

The nutritional dietary consumption of carbohydrates is between 55-75% for the vast majority of the global population as their main source of food intake and energy.  And the general populous continues to be misinformed by government agencies regarding what a normal, healthy diet, should be, as well as what a balanced diet looks like.  Eating a low-carb high-fat, or ketogenic, diet of high fat, adequate protein and low carbohydrates can provide many health benefits as compared to the alternative of an unhealthy diet. Research suggests that a ketogenic diet builds a healthier body than

While Season felt completely broken-down, she knew that she had no choice but to bring her background in nutrition to her own home. To build Kicker’s immunity Season implemented The Ketogenic Diet. The human body produces cancerous cells daily, so building a strong immunity is imperative when fighting off cancer cells and the harsh chemicals from treatment. The Ketogenic Diet is a new cancer treatment, which is free, with virtually no side effects. It can also be conjoined with other cancer treatments. The diet involves cutting carbohydrates, beginning with the worst carbohydrate of all, sugar (Johnson L, 2013). It is a high-fat, adequate-protein, low-carbohydrate diet. The diet forces the body to burn fats rather than carbohydrates. Normally the carbohydrates contained in food are converted into glucose, which are then transported around the body. However, if there are little carbohydrates in the diet then the liver converts fat into fatty acids and ketone bodies. Ketone bodies are water molecules that are produced when the body is consuming very little food, which mimics fasting. Cancer is an obligate glucose metabolizer because it fuels on sugar. One’s normal cells have the metabolic flexibility to adapt from saving glucose by using ketone bodies (Johnson S, 2014). This addressed that because cancer

Magnetic resonance spectroscopy measures the chemical composition of tissues and provides information about major cellular metabolites. A common pattern of brain tumors is a decrease in N-acetylaspartate (NAA), a decrease in creatine (Cr), and an increase in choline (Cho), lactate (Lac), and lipids (L). Cho/Cr and Cho/NAA ratios have the superior diagnostic performance in predicting the glioma grades.

The ketogenic diet; one of the oldest treatments for epilepsy is based on the creation of ketones in the body. The creation of ketone bodies is accomplished through high fat intake, carbohydrate depletion and a fasting-metabolism; over long periods of time. When the body is in a fasting state, it creates ketones, a by-product of a fat-burning metabolism. It has long been recognized that seizures often lessen or disappear during periods of fasting in some individuals with epilepsy (Richard Senelick, 2014). This fat-burning metabolism is slowly become popular amongst dieters and endurance athletes. Besides the clear loss of body fat there is the increase in brain processes that create extreme amounts of clarity.

“Patients can face modifications in their quality of life due to frequent headaches, nausea, seizures, neurological or cognitive deficits, and insomnia. Furthermore the treatment itself is often toxic and can result in considerable morbidity” (Gazzotti, Mariana, 2011). “Until recently, assessment of treatment response in brain tumor patients has been associated almost exclusively with radiological imaging response (characterized by tumor reduction in tumor dimensions), progression with symptoms and overall survival” (Gazzotti, Mariana, 2011). “In addition, quality of life may also reflect cognitive dysfunctional and functional limitations associated with the disease or as a treatment complication in these patients” (Gazzotti, Mariana, 2011). People suffering from brain cancer already go through an immense number of complications dealing with their disease alone, and the surgeon should really focus on the impact of treatment on the patient’s quality of life. Some common risks of Brain surgery are: bleeding of the brain, blood clots, brain swelling, coma, impaired speech, vision, coordination, or balance, and many more risks are

Ketosis is a normal metabolic process where the body has a high fat-burning rate. A low-carb and high fat diet is required for ketosis. Ketosis is when everything is good and your body is running on fat rather than glucose. The ketosis diet is therefore receiving more attention as people become aware of the harm of consuming too many carbohydrates.

Neuro-Oncology is the study of cancer in the brain, skull base, or spinal cord. They can also treat genetic disorders of a certain type such as Neurofibromatosis. Neurofibromatosis is tumors that grow in the nervous system that is caused by a genetic disorder. The main purpose of the research was to gain information on Neuro- oncology, general information on brain tumors, and general information on specific tumor types. Central nervous system tumors include various gliomas such as glioblastoma multiforme, astrocytoma, brainstem glioma, ependymoma, and oligodendroglioma. Furthermore, meningioma and vestibular schwannomas. Other conditions neuro-oncologist can treat are central nervous system lymphoma, metastic disease to the spine

Cancer is the second most prominent cause of death in the United States. In the year 2016, it is predicted that 595,690 Americans will die from this disease.12 Caner is defined as an uncontrollable division of cells in the body that spreads into surrounding tissue. This rapid division of cells can occur almost anywhere in the human body. The cancer treatments currently available in modern medicine include a combination of chemotherapy, radiation, and surgery. Recently scientists have discovered that there could be another way to battle this epidemic. There proves to be a strong correlation between this rapid cell division that is seen in cancer patients with the metabolism of glucose. Glucose provides the energy needed for these cells to continue to rapidly divide and develop new cells. This could mean that nutrition may be a very valuable weapon in the war against cancer. 5 A high fat, low carbohydrate diet, also known as a ketogenic diet, has been successful in the clinical world for patients with uncontrollable seizures, but it may now pose as a viable resource to assist in cancer recovery. By restricting carbohydrates through diet, thus starving the cancer cell of glucose, we may be able to slow or terminate the spread of these cancer cells. The objective of this paper will be to give a better insight on how a Ketogenic diet may aid in delaying or terminating cancer.

If a patient chooses to go a community based treatment route, the NCI, or National Cancer Institute, is an option they may consider. The NCI has 69 Cancer Centers that spread among 35 states. These centers include several university medical centers as well as freestanding cancer centers. The main roles of these centers are focusing on studying and controlling cancer. (National Cancer Institute [NCI], 2015)

Brain tumors appear as unexpected, scary, confusing, and powerful. The brain contains the control system, the personality, the memory, and more. Tumors form when cells have defects in the DNA which make them multiply uncontrollably; there consist of many types, symptoms, treatment, and different kind of doctors to treat it. When patients identify symptoms early and seek medical treatment in a timely fashion, survival

The Ketogenic Diet is a way of eating that is becoming increasingly popular within fitness and health communities. The Ketogenic Diet began as a way of eating to combat Alzheimer’s disease along with neurological disorders such as Multiple Sclerosis and Parkinson’s Disease (Davis, n.d.). In the past decade it has become widely known for its weight loss benefits. As of recent, many famous public figures and professional athletes have further popularized the concept of the Ketogenic Diet. Many years ago, the Ketogenic Diet began as a way to combat diseases and neurological disorders, but has since then become a much more popular tool for weight loss.

Common malignant brain cancers increase significantly according to statistical data collected by the National Cancer Institute. In 1984, the annual incidence rates of primary brain tumor and primary brain lymphoma also increased notably, the rate of lymphoma almost tripling,

Malignant gliomas are the most common type of primary malignant brain tumor, and glioblastoma accounts for 82% of cases of malignant glioma. Glioblastomas arise from glial precursor cells and are characterized histologically by considerable cellularity, mitotic activity, vascular proliferation, and necrosis. They are highly invasive, infiltrating surrounding brain tissues, yet they are typically confined to the central nervous system and do not metastasize.1 From a molecular standpoint, malignant glioblastomas are heterogeneous tumors, and genome studies have demonstrated four transcriptional subclasses. These four classes display features of distinct cell types: classical, mesenchymal, proneural, and neural.1 Patients with glioblastoma experience a wide variety of complications from both the disease and drug therapies. Current standard therapies for glioblastoma are maximal safe surgical resection followed by temozolomide and radiotherapy. With these therapies the median patient survival is less than 2 years due to common tumor recurrence.2 However, new therapies such as targeted vascular endothelial growth factor inhibitors, carmustine wafers, and gene therapies are promising in prolonging survival and delaying progression of the disease.