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Knee Research Paper

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The bones in the upper and lower leg of Human body are connected by complex pivotal hinge joint called knee. The upper and lower extremities are encompassed of tendons, cartilage, ligaments and muscle. Menisci, two concave pads of cartilage, disperse the friction created at the meeting of the ends of the tibia and femur. The key ligaments of the knee are Medial Collateral ligament (MCL), Lateral Collateral ligament (LCL), Anterior cruciate ligament (ACL), Anterolateral ligament (ALL), and Posterior Cruciate ligament (PCL).

The knee is comprised of articular cartilage that is hyaline cartilage. Articular cartilage unlike most tissues, lack nerves, lymphatic and blood vessels. It is composed of a sparse distribution of chondrocytes …show more content…

Collagen is secreted as pro collagen by fibroblasts and is aggregated into fibers. Type I collagen is the most common type and is found in ligaments and tendons. Meniscus is a piece of cartilage in the joint space where two bones meet. They are found between the ends of upper and lower leg bones in the knee. They absorb the shock and protect the joint surface from activities like running, walking and jumping. The menisci are mainly composed of type I collagen which supports the meniscal structure. Type I collagen is the main difference between menisci and articular cartilage which is composed of type II collagen. Another component of menisci is fibrochondrocytes intermixed with extracellular matrix. These fibrochondrocytes synthesize and maintain collagen and exhibit properties of chondrocytes and fibroblast. There are three layers of collagen fibers arranged to convert compressive loads into circumferential or stresses. The fibers run radially serve to resist splitting or shearing in the superficial layer where as they run parallel to resist stress during weight bearing in the middle layer. In the deep layer, they are aligned parallel to the

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