Lab On A Chip Lab Report

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Introduction The research is specifically carried out on Particle Sorting using the interplay between the Travelling Surface Acoustic Wave and the Stationary Surface Acoustic Wave. Sorting individual cells/particles of interest from a heterogeneous population has been of critical importance in biological studies and clinical applications, such as single cell sequencing, rare cell isolation, and drug screening. The introduction of “lab-on-a-chip” (i.e.,

small-sized analytical devices) has spurred steadily increasing interest and research efforts in the microfluidics discipline (upon which lab-on-a-chip devices are based). The promise of such lab-on-a-chip devices is grounded in the advantages of microfluidics relative to traditional
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Displacement of acoustic waves is also helpful in creating particle mobility required for separation of particles in a static fluid volume. In batch systems, with very small samples in contact with a substrate, separation has been shown using acoustic streaming in droplets, in an open chamber and in a channel.

Description of Research Methodology In this research we will examine the use of acoustic radiation forces alone for particle separation in a system, and demonstrate that the controllability of this type of acoustic force allows highly specific separation. SAW is generated by a spatially periodic electrical field to create a resonant condition on a piezoelectric substrate.

Further, in TSAW a wave travels through the substrate and in case of SSAW, there are 2 counter propagating wave. We will utilise both TSAW and SSAW; the former acts to push the particles across the chamber, the latter to capture particles in bands of minimum force potential. The system will consist of a microfluidic chamber, cast in polydimethylsiloxane (PDMS), and bonded onto a lithium niobate, LiNbO3 (LN) piezoelectric substrate.

The device will be held under a microscope using a frame. The
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