Lab Report On Small Molecules

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3. Review on small molecules
a) Small molecules
Small molecules are the low molecular weight organic compounds having capacity to inhibit the growth of bacteria or their virulence potential. Previously, antibiotics were used for these purposes but today we need to be curious before using antibiotics due to the developing resistance. If antibiotics develop resistance, they are no longer effective for prevention, treatment or control of diseases caused by infectious microorganisms. Researchers are now exploring the new strategies and new compounds that can take the advantageous place in front of antibiotics. Use of probiotics, vaccine, herbal extracts are some of the new strategies. On the way of discovery and research, scientists are now
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Similarly, a high throughput screen reveal nitrofuran , napthalimide, salicylanilide, bipyridinium and quinozolinediamine as the most potent antibacterial against E. coli and P. aeruginosa (La Fuente, Sonawane, Arumainayagam, & Verkman, 2006). Compound [2-oxo-2-(5-phenyl-1,3,4-oxadiazol-2-ylamino)ethyl 2-naphtho[2,1-b]furan-1-ylacetate] inhibited the growth of antibiotic-resistant Gram-positive bacteria S. aureus (Richter et al., 2013). High throughput assay system identify 10 compounds that were highly specific to inhibit M. tuberculosis growth (Arora et al., 2014). Similarly, HTS of small molecules identified 206 growth inhibitors of a Burkholderia cenocepacia among 30,259 screened compounds (Selin et al., 2015). The small molecule, 2- imino-5-arylidene thiazolidinone reveal the inhibitory potential for virulence in S. typhimurium, Yersinia, Pseudomonas, and Francisella strains (Giller & Viteva, 2013).Thus, high throughput screen combined with vitro and in vivo analysis of the identified compounds directs the starting point of alternative antibacterial drug discovery.
c) Potentiality of small molecules
Understanding precise mechanism behind the inhibition will further strengthen the role of small molecules as an alternative. Due to different novel mechanism of inhibition, less bacterial resistance is expected against these compounds than those of conventional antibiotics. Small molecules
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