Introduction Lambert-Eaton myasthenic syndrome, also known as Eaton Lambert syndrome, is an autoimmune disease that is characterized by the onset of severe muscle weakness. The muscle weakness involved with Lambert-Eaton myasthenic syndrome (LEMS) typically occurs in the pelvis and thigh muscles. Approximately 60 percent of LEMS cases are associated with a small cell lung cancer (SCLC), and the onset of LEMS symptoms often precedes the detection of the cancer (Gozzard). Patients who have LEMS that also have cancer tend to have a history of smoking and are usually older adults. LEMS occurs often in men with tumors in their chests, especially lung cancer. Individuals without cancer can develop LEMS at any age. However, LEMS is rarely seen in children and this disease is not hereditary. This disease is also more common in men than in women and the progression depends on whether it occurs with cancer. LEMS is named after Edward Lambert and Lee Eaton. These men were neurologists at the Mayo Clinic in Rochester, Minnesota and they described Lambert-Eaton myasthenic syndrome in the 1950’s and 1960’s. Approximately 400 people in the United States have LEMS. This disease is an autoimmune disease in which the immune system attacks the body’s own healthy tissues. The immune system attacks neuromuscular junctions, which are the areas where a person’s nerves and muscles connects. This then affects the way muscles and nerves communicate and make it difficult to move muscles. LEMS
Multiple sclerosis is a chronic, progressive neurological disease affecting all aspects of life: physical, cognitive, emotional, and social (Abma). It is known as an autoimmune disease, Where the body’s immune system turns against the body and destroys the protective covering that surrounds nerve cells. This damage to the nerve cells causes many problems for the patient including weakness, muscle stiffness, poor coordination and balance, tingling, numbness, tremors, blurred vision, slurred speech, and memory and concentration problems (Bren)
Let alone the cause of this horrible disease. One of the most commonly suspected reasons for systemic lupus erythemotosus (SLE) is a very low iron count. Low iron has a veriaty of effects on the body including the feeling of being cold, low blood count (anemia), and impaired immune defiecency, ect.. Thus the low iron syptom seems to add up with lupus making doctor think that low iron can have a leading from in the disease.
Multiple Sclerosis (MS) is an autoimmune disease that attacks the central nervous system. The myelinated nerve cells get attacked which results in scars and lesions that destroy the myelin sheath. The reason for the body attacking its own nerve cells is unknown. Many believe that the cause of MS is from a virus, a deficiency in Vitamin D, or genetics. Studies are being done to find out what is the real cause of MS.
Multiple Sclerosis (MS) a disease which the immune system attacks the protective sheath also known as the myelin that covers the nerves. Damages myelin disrupts the communication between the brain and the rest of the body. The nerves itself may weaken, process that is currently irreversible.
The father of neurology, Dr. Charcot, examined the brain of a deceased patient because the patient had a tremor unlike anything he has treated before. He noticed plaques or abnormal clusters of chemically sticky proteins that build up amongst nerve cells. He also described the patient’s symptoms and changes in the brain that accompanied the plaques; this was the first description of multiple sclerosis. In England in 1873 and in the United States in 1878, multiple sclerosis was first recognized based off of Dr. Charcot’s description of the disease. In 1916, Dr. James Dawson performed autopsies on brains of patients who died with multiple
This disease affects the nerve cells by enabling them to send electric impulses to the muscles which ultimately makes the muscle wither away and stop working. The nerves targeted are actually
Emery-Dreifuss muscular dystrophy (EDMD) is a rare form of muscular dystrophy. It is another one that only affects boys that appears from childhood to the early teen years and sometimes as late as the age of twenty five. It causes muscles weakness and wasting in the shoulders, upper arms, shins, and often causes problems with the joints becoming tighter. Life threatening heart problems are common and can also affect those who do not have this disease, but simply carry the genes for it. This is a slow progressing disease and often has slow progressing muscle weakness compared to other forms of muscular dystrophy.
Multiple sclerosis is a disease of the central nervous system. It most commonly occurs in individuals between the ages of twenty and forty (1) and in higher numbers of women than men (2). In Multiple Sclerosis (or "MS") a loss of the nerves' axon coating myelin prohibits the nerve axons from efficiently conducting action and synaptic potentials. Scar tissue (called plaques or lesions) forms at the points where demyelination occurs in the brain and spinal cord, hence the name "Multiple Sclerosis"or "many scars" (3). The demyelination found in MS is thought to be caused by an autoimmune process, in which the body's immune system attacks its own healthy tissue (4). Other diseases thought to have an autoimmune basis are
Myasthenia gravis [MG] is a rare, autoimmune neuromuscular disorder. The incidence rates has been reported as 2-7/10000 in central and western Virginia ( Thanvi ,2004).The onset of [MG] is depends on age and gender .In patients younger than 40 years, women are more susceptible than man to [MG],with a ratio of 7:3 :Above the age 50 [MG] are slightly more common in men with a ratio 3:2.Myasthenia gravis are very rare in children.Juvinile [MG] is an autoimmune disorder ,while congenital [MG] results from genetic mutations that impair neuromuscular transmission. It has been suggested that incidence of [MG] falls after 70 years of age. A recent study using AChR antibody as a diagnostic
Looking back, there were a lot of things that made more sense following my diagnosis with Ehlers-Danlos Syndrome, commonly referred to as EDS. This is a rare genetic condition separated into six different types; Classical, Hypermobility, Vascular, Kyphoscoliosis, Arthrochalasia, amd Dermatospraxis. There are varying degrees of symptoms and seriousness but a common thread is the defect in the collagen proteins which allow the skin, joints, connective tissues, and organs to function properly. EDS can also lead to many other unrelated diseases or disorders due to the malfunction in the body. The varying types and degrees in which EDS manifests itself makes getting a diagnoses difficult, especially at a young age.
Stevens-Johnson Syndrome is extremely rare, affecting between 2.6 to 7.1 people per million each year. The disorder can affect anyone, however, studies show that SJS is twice more common in females, more common in caucasians, and elderly people as they are more likely to use the medications that cause it. The condition is 100 times more likely to occur in people who are HIV-positive and those with systemic lupus erythematosus,
Multiple Sclerosis is also known as MS and is a disease of the central nervous system. It is a chronic inflammation disease that is immune-mediated and attacks the protective sheath that covers the fibers of the nerve and causes problems of communication between the brain and the remainder of the body. This disease will eventually cause the nerves to deteriorate or become damaged permanently. Multiple Sclerosis has the potential to disable the brain and spinal cord. The cause of this autoimmune disease unknown. The body’s immune system attacks its own tissues.
Ehlers-Danlos syndrome is one of several disorders that can affect the body in similar fashion, so doctors need to make a differential diagnosis to ensure that it is not something else, such as Marfan syndrome. Like EDS,
While the progressive neurological symptoms of MS have been observed in patients through medical history, it wasn 't until 1868 that it was given a name and defined by Jean-Martin Charcot
During SLE, the body’s immune system doesnt work as it should. In a healthy immune system, the body makes special proteins called antibodies and a specific type of white blood cell called lymphocytes. These two components are crucial to healthy immune system because they help to fight and destroy foreign viruses and bacteria that can be harmful to the body. In SLE the immune system produces harmful antibodies that work against the body’s healthy cells and tissues which are called autoantibodies. Autoantibodies cause inflammation in the body that could severly damage organs and tissues. Most people tend to develop an