Leukemia And Its Effect On Bone Marrow

Leukemia is a cancer of blood cells, specifically white blood cells that are responsible for fighting infection. However, the abnormal cells in leukemia do not function in the same way as normal white blood cells. Leukemia cells continue to grow and divide, eventually crowding out normal blood cells. The end result is that it becomes difficult for the body to fight infections, control bleeding and transport oxygen (Medicine Net, 2015). It is estimated that each year, approximately 30,800 individuals will be diagnosed with leukemia in the United

According to the American Cancer Society (2013) stated, “Leukemia is a cancer that starts in early blood-forming cells” (American Cancer Society, 2013). “Most often, leukemia is a cancer of the white blood cells, but some leukemias start in other blood cell types” (American Cancer Society, 2013). “Any of the cells from the bone marrow can turn into a leukemia cell” (American Cancer Society, 2013). According to the American Cancer Society (2013) stated, “Once this change takes place, the leukemia cells don’t go through the normal process of maturing” (American Cancer Society, 2013). There are changes that leukemia cells can quickly reproduce themselves and not die when they are suppose too (American Cancer Society, 2013). “They survive and build up in the bone marrow, crowding out normal cells” (American Cancer Society, 2013). “In most cases, the leukemia cells spill into the bloodstream fairly quickly” (American Cancer Society, 2013). “Almost all childhood leukemia is acute leukemias” (American Cancer Society, 2013).

Leukemia is cancerous disease that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the blood-stream (National Cancer Institute, 2008, para. 1). It is one of many complicated cancer diseases that affect all ages and have very negative outcomes if not treated properly, and on time. Within the disease are several different types that affect according to how quickly the disease develops and attacks the body. It could be classified as chronic leukemia, which has a slow progress of getting worse or acute leukemia which usually gets worse quickly. The types of leukemia also can be grouped based on the white blood cell that is affected (National Cancer Institute , 2008, p. 1).

How Leukemia starts is with the DNA of immature blood cells, mainly white cells, that get damaged somehow. That causes blood cells to grow chaotically without stopping like the body tells it to. If you didn't know normal cells die after a while and are replaced by a new one which are produced in the bone marrow. Abnormal cells don't die so easily and that is why when they keep multiplying they occupy more and more space and then the normal cells

Cancer is defined as the disease caused by an uncontrollable division of abnormal cells in a part of the body. The particular cancer that I️ researched is Non-Hodgkin Lymphoma (NHL) which is a type of cancer that begins in the cells of the lymph system. (Lymphoma) The lymph system is a part of the immune system. Lymph tissue is found all throughout the body; therefore, Lymphoma can begin from almost any part of the body since the major sites of lymph tissue are the lymph nodes, spleen, bone marrow, thymus, digestive tract, and adenoids and tonsils. (What) “In most cases, it is not known what causes Non-Hodgkin Lymphoma.” (Risk) Some risk factors of NHL are beyond our control such as age and gender but usually they are acquired rather than inherited. (Risk) NHL begins in white blood cells called lymphocytes. (What) There are two main types of lymphocytes: B lymphocytes ( B cells) and T lymphocytes (T cells). B cells normally create antibodies to

Leukemia is cancer in the bone marrow and the lymphatic system and affect the body's blood-forming tissues. Leukemia usually involves white blood cells. Your white blood cells fight off infections. People with leukemia, the bone marrow produces abnormal white blood cells, which don't function properly. Scientists don't understand the exact causes of leukemia. It is believed to develop from a combination of genetic and environmental factors. In general, leukemia is thought to occur when blood cells acquire mutations in their DNA. The CD34 phenotype. Certain abnormalities

The type of cancer I chose to write about is called acute lymphoblastic leukemia. Acute lymphoblastic leukemia is developed through damaged bone marrow and blood cells. Stem cells form blood cells, these stem cells that form white cells start out as cells then generate into blast cells, or also known as lymphoblast. Lymphoblast then produce a cell a type of white blood cell known as lymphocytes. This damaged cell then becomes a leukemic cell and multiples into billions of cells leukemic lymphoblast cells. This then causes the number of healthy blood cells to drastically lower. The origin of the word "acute" comes from the fact that the disease progresses rapidly and creates immature blood cells, rather than mature ones. It also can be called acute lymphocytic leukemia. Acute lymphoblastic leukemia is a

Leukemia is a cancer that affects the bone marrow. The bon marrow is the soft spongy center of the bone that produces blood cells. Leukemia is found in white blood cells or leukocytes. The white blood cells help to fight ff infections and other diseases. Normally, cells produce in an orderly way, but people that have leukemia the cell production gets out of control. The marrow produces too many immature white blood cells called blasts. They are differently shaped and can’t carry out their usual duties.

Cancer cells are unusual cells that multiply and devastate the fundamental organs of the body. They breed inside the tumors and live off on the oxygen and other nutrients. When the tumors cut into the blood stream they can insert the cancer cells and spread around very easily. If they enter the lymph nodes they straight away win over the immune system.

Leukemia is a type of cancer that starts of in blood-forming tissue. This disease is caused by the uncontrolled growth of blood cells in the bone marrow. White blood cells are the main culprit to the formation of this diesis even though they are essential components of the body's immune response to sicknesses and diesis. The way this diesis spreads throughout the body is when the leukemia cells overpopulates and replaces normal blood cells in the bone marrow. This cancer is not formed through genetics, but just forms in the body. As a result, this cancer cannot be prevented.

The research paper “CD47 is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells” found a new cancer marker to target for treatment of a type of bone marrow cancer.

Acute Lymphocytic Leukemia is a scary disease. The term “acute” means the disease can quickly spread and progress quickly and can prove fatal in months if left untreated. “Lymphocytic” simply means that it develops from immature forms of lymphocytes. Also known as Acute Lymphoblastic Leukemia, or ALL for short, it is a type of cancer that starts from the early form of white blood cells called lymphocytes in the bone marrow. ALL is the most common form of cancer in children, though adults can get it as well. For children, treatment results in a good chance of a cure. Adults have a significantly smaller chance of a cure with ALL. ALL generally invades the blood very quickly and has the potential to spread to other body parts such as the spleen,

I am Gino Dettorre, and I will be a senior at Bishop Watterson High School this coming school year. Currently, I am interested in pursuing a major in biology with a minor in Spanish at either Washington University in Saint Louis, University of Pennsylvania, or Vanderbilt University. While participating in the Mechanisms of Human Health and Disease program at Children’s Hospital, I have gained a better understanding of the molecular bases of various diseases, and I am interested in applying this knowledge in a laboratory setting. I have chosen to research acute myeloid leukemia because I have known relatives and friends affected by blood cancers, and I am interested in better understanding the mechanisms of this disease.

There are two main and four specific types of leukemia. The two main types are acute leukemia, which is fast growing, and chronic leukemia, which is slow growing. The four specific types of leukemia are chronic lymphocytic (CLL), acute lymphocytic (ALL), chronic myelogenous (CML), and acute myelogenous (AML) that were discovered in 1913. About three quarters of children diagnosed with leukemia have acute lymphocytic which peaks as early as two to four years old. This cancer kills more children that are two or fifteen than anything else. To determine whether the cancer will be chronic or acute is to look at the cell lineage. The blood cell that becomes cancerous explains what type of leukemia it is. Depending on if the white cells, the red blood cells, or the platelets can determine exactly which leukemia it is. “Adults can get either type; children with leukemia most often have an acute type” (Leukemia: MedlinePlus). For a child to get a chronic leukemia is very rare. Now it is known that the cancer starts in the bone marrow, which is where blood cells are formed. Leukemia causes the body to create too many abnormal cells and these abnormal white cells cannot fight infection and also lessen the amount of red cells and platelets. Some of the risk factors of this cancer are large doses of ionizing radiation, being exposed to benzene for a long period of time, rare viruses, genetic disorders, and

Once these cells become leukemia cells then they no longer mature nor form normally. These cells may reproduce quickly and not die when they should, or can build up in the bone marrow and begin to crowd other healthy cells.