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Liposomal Bupivacaine Experiment

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Surdam et al. published a randomized prospective study done on (N= 80) patient comparing the efficacy of Exparel versus femoral nerve block (FNB). Study was performed on patients older than 18 who underwent unilateral TKA and who understood spoken and written English. Primary outcome of the study was to evaluate inpatient pain score comparing liposomal bupivacaine in contrast to
FNB. Other clinical outcomes of interest were ROM(extension and flexion), nausea and vomiting, narcotic consumption, ambulation distance, and length of stay (LOS). Results from the study showed no difference in pain score between the two groups. The mean pain score for the patients during their entire hospital stay in the FNB group was 2.92 ± 2.98 whereas mean pain score …show more content…

This significant difference (p=0.07) in pain score is more noticeable during POD0 (FNB=2.91; liposomal bupivacaine=3.84), but over the next 24 hours after surgery it diminishes to identical. ROM showed improved flexion in the FNB group (FNB=101 degrees Passive flexion vs: liposomal bupivacaine group=94 degrees passive flexion).This result was statistically significant (P = 0.001). The amount of flexion between the two groups did appear to level out after the first 24 hours of surgery. No statistically significant differences in nausea (P = 0.17) and vomiting (P = 0.64) between the FNB and liposomal bupivacaine groups. Surprisingly, the patient in FNB group on POD0 required significantly fewer opioids than the liposomal bupivacaine group (13.9 mg vs 25.5 mg, respectively) but on POD 1 the liposomal bupivacaine group patients required

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