Essay on Liraglutide: Novel Treatment of Type 2 Diabetes Mellitus

Type II Diabetes, also known as diabetes mellitus, is also called non-insulin-dependent diabetes or aadult onset diabetes. It is a medical disorder that, due to a number of factors codependent with the modern world, is characterized by higher than normal blood glucose levels that play havoc with insulin deficiency and resistance. Insulin resistance means that cells do not respond appropriately when there is free insulin in the blood system. Essentially, they body is reacting to an improper balance of sugars and insulin. Because obesity is often present, research suggests that even thought the mechanisms controling glucose and insulin are unclear, the adopose tissue likely

This article discusses the use of dulaglutide and sitagliptin in the management of type 2 diabetes. Dulaglutide is a recombinant GLP-1 Fc fusion protein, which acts by linking GLP-1 analog peptide and a variant of lgG4 Fc fragments in humans. As such, the analog of GLP-1 has posed effects and has shown elevated efficacies in the management of type 2 diabetes. The primary efficacy in the baseline of HbA was altered during the end of 52nd week. The objective of secondary efficacy included a change in HbA during the end of the 26th and 104th week. The percentage of patients achieved HbA targets ranged between 7.5% to 6.5% in a central laboratory and the body changed significantly. However, current treatment majorly focuses on increasing

Answer: The combination of Insulin as well as oral hyperglycaemic drugs may be prescribed for Diabetes because they help in lowering the blood glucose levels. However the primary treatment doesn’t consist of these drugs. The primary treatment comprises of Diet control, Physical activity and Weight control. If after following the primary treatment strictly, no improvement in the blood glucose level is achieved then medication is suggested for the same. Insulin helps in maintaining the blood sugar levels. Note that insulin is not to be taken orally because the acids and digestive juices in the stomach destroy it. It has to be injected under the skin only. Taking insulin leads patient to experience Hyperglycaemic condition. The Hyperglycaemic drugs helps our body to react appropriately with the insulin so that the insulin hormone is able to help transfer glucose from blood to the cells successfully.

Everybody knows that obesity is a big factor in developing type-2 diabetes, and that part of coping with this metabolic disorder is lifestyle change. If blood glucose does not go down, then medicines are introduced. Some type-2 diabetics even have to administer insulin in order to keep their blood glucose levels

Type II diabetes is a disease that affects millions of people in the United States and is also a disease that is continually growing in numbers. The cost of the individual and national health care systems is also a number that is growing. Policy for prevention of diabetes and pre-diabetes is something that while has changed some in the past, has been basically the same for the past 20-25 yeas. This disease affects many throughout the country, but effects those in the middle and lower classes due to the cost of eating healthier being greater than the alternative and also due to the fact that these groups are less likely to go for routine health care.

In order to combat the epidemic of type 2 diabetes in America, a series of subsidies and social programs promoting and mandating nutrition and exercise for weight loss should be created with the trillion dollar budget. The prevalence of type 2 diabetes in America is rising and has doubled over the last 30 years to 23 million (Campbell). Currently, it costs the nation about $90 billion a year to treat the complications of type 2 diabetes (Hoerger). Added with the co-morbidities of type 2 diabetes, namely cardiovascular disease, obesity, and kidney failure, it becomes apparent that drastic measures are needed. In order to combat this epidemic, the U.S. Congress is proposing to use a trillion dollars to do whatever it takes to reduce the

Diabetes affects over 180 million people in the US and is projected that by 2025 this figure will increase to 300 million.

Diabetes is a growing concern and health challenge for the American people (b). Diabetes is a condition in which the body cannot react to insulin appropriately or either cannot produce insulin efficiently (w). “Without a properly functioning insulin signaling system, blood glucose levels become elevated and other metabolic abnormalities occur, leading to the development of serious, disabling complications” (w). There are numerous forms of diabetes amongst the nation, however, there are three main forms of diabetes. Most people have heard of type one diabetes, type two diabetes, and gestational diabetes because they are common. Type two diabetes deals with a resistance to insulin, while

Treatment of diabetes is important to minimize the harm that is done to the body by diabetes. In addition to exercise and a special diet, type 1 diabetes patients need regular insulin injections to lower the blood sugar levels, while people with type 2 diabetes usually don’t need insulin shots, most of them require insulin tablets in addition to healthy diets and regular exercise and a few don’t even need the insulin tablets. (2, 7)

Type II Diabetes is a growing disease that according to Ley, Ardisson Korat, Qi, Tobias, Cuilin, Lu and ... Hu (2016) approximately 415 million adults are affected by this disease world wide and in the United States in 2015, $348 million dollars was spent on treatment for diabetes. Additionally, the growing number of people who are projected to develop type II diabetes is

Considerable advances in the past treatment of type II diabetes include the application of lifestyle intervention and prevention efforts aimed at delaying development of glucose intolerance in order to evade diabetes and the progression of new curricula of glucose in the blood-lowering prescriptions to appendage current treatments (DeFronzo, 2010) (Mazzola, 2012). Presently, the control and maintenance of type II diabetes centres on control of glucose by the decrease of haemoglobin and glucose in the blood (DeFronzo, 2010). Current treatment strategies focus on the progression of therapeutic factors that affect the defects contributing to type II diabetes and thus, provide sustainable glucose control through a delaying of disease development

Mrs. Scott is receiving glyburide, a sulfanuria, to treat her diabetes mellitus type II, formerly know as adult onset or non insulin dependent. Type II diabetes mellitus involves a decreased ability to use the insulin produced by the beta cells of the pancreas (Doenges, Moorhouse, and Murr 2010, 1). Sulfanuria drugs, such as glyburides, are specifically used for lowering the glucose level in the blood by working on three of the four main metabolic factors of type two diabetes. In type II diabetes, there are four main metabolic factors that are involved in the regulation of insulin and glucose; insulin production in the pancreas, glycogenolysis in the liver, adipokines regulation in the adipose tissue, and receptor site sensitivity in the muscles.

Today, millions of new people become affected by type 2 diabetes every year. Diabetes ranks seventh among the leading causes of death in the United States and is causes more deaths than breast cancer and AIDS combined. Most people don't know how deadly this disease is. Weight loss is a primary goal towards preventing the disease. Therefore, almost every day companies introduce new medicines, pills, and diet plans that promise weight loss. These techniques are not always effective and they can be extremely expensive. However, there is an inexpensive old stand-by called “exercise” that has been proven over and over to reduce and control weight. Exercise is the most offered suggestion by doctors to prevent adult onset diabetes. People have to

One of the most serious (and misunderstood) diseases that affects our country today is type II diabetes. While many people may not understand exactly what type II diabetes is, it is actually quite simple: "Type II diabetes is a chronic condition that affects the way your body metabolizes sugar (glucose)- your body's main source of fuel" (Mayo Clinic, 2006). Type II diabetes is the most common type of diabetes, with approximately 90 to 95% of the 21 million Americans who suffer from diabetes have type II diabetes. It has been estimated that one-third of people with type II are not aware that they have it; if it goes undiagnosed for a long period of time the disease can become life-threatening (Mayo Clinic, 2006).

Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.