Literature Review On Gout

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LITERATURE REVIEW

The imbalance of trace elements was shown is involved in many disorders, such as Gout. Sixty four elements were measured in the serum samples of Gout patients with in three regionally and healthy control group by inductively coupled plasma-mass spectrometry (ICP-MS). An elemental profile of Gout notably altered Al, Li, Ti, Se, Fe, Cu, Sr, Ta, Hg, U, Th, and Bi. An independent group of 39 gout patients and 13 healthy controls was further used to confirm the elemental analysis, yielding a sensitivity of 1.00 and a specificity of 1.00 for Gout forecast. A good link was also observed between Li, Zn, and Cu and further two risk aspects, age and serum urate concentration, in Gout patients. Therefore it was accomplished that gout has a distinctive elemental profile despite of many other nutritional and environmental factors [1].
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In recent decades, studies have shown that the development of Hyperuriemia and Gout is due to effect of lead on the tubular urate transport causing diminished urate excretion. In the case of lead intoxication these effects were mostly linked with renal failure. The clinical features of saturnine gout were basically same as that of primary gout; though, acute attacks were likely to occur in the knee more recurrently. The analysis of saturnine Gout was based on the history of exposure to lead, lead toxicity, high serum lead levels and various other abnormalities. The treatment of Gout consists of eliminating the further exposure to lead from the patient, to utilize chelating agents for removal of lead, and management of acute Gouty Arthritis and Hyperuricaemia
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