Lncrna Essay

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Lnc RNA in human diseases
Human lncRNA is versatile and has many cellular functions like alternate splicing, nuclear import, epigenetics, RNA turnover, translation and regulation (Tani, 2017).thus in medical research, lncRNA is achieving importance as their dysregulation is directly associated with diseases like cancer. They act as a precursor of siRNA and has both tumor suppression and oncogenic property. Few of the roles of lncRNA in disease are described below. (Lo, Wolfson, & Zhou, 2016) MIR4435-HG
It has been reported in lung cancer tissues and cell line MIRL lncRNA acts as an oncogene. This downregulation is confirmed by knocking down MIR4435-2HG in lung cancer and treating the lung cancer cells with resveratrol. In both the cases,
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Thus, silencing HOTAIR affects the action of PRC2 and LSD1. Recent studies revealed that HOTAIR can control estrogen receptors and chromosome pS2 hTERT, human telomerase reverse transcriptase (Tani, 2017). Hotair is overexpressed in breast tumors, colorectal cancer, and hepatocellular cancer which can be used to predict death and metastasis. (Shi et al., 2013) MALAT or Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1 or Neat2) MALAT1 well-known lncRNA is often related to cancer metastasis and so it can be used as a marker for prognosis of cancer in early stages of non small cell lung cancer. MALAT was found to colocalize several highly expressed genes. However, they exhibit different binding patterns and have certain cytosolic functions. Serine-arginine (SR) splicing factor phosphorylation and distribution is affected by MALAT1. Further studies conducted in the MALAT1 knock out mouse model shown that MALAT1 is not only crucial for cell motility, invasion but also essential for prenatal and postnatal development in such mouse. lncRNA regulation Disease function
MIR4435-
2HG up Lung cancer oncogene
ANRIL up lung, ovarian cancer, bladder cancer, gastric cancer, hepatocellular carcinoma, and colorectal cancer Oncogene. Binds with PRC-1/2 Causes transcription repression of p15 and p16
MALAT1 up non small cell lung cancer, osteosarcoma, uterus cancer, breast cancer,

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