Long QT Syndrome Research Paper

Apical hypertrophic cardiomyopathy is a disease that mainly affects the apex of the heart and does not cause any obstruction. [1] These abnormalities in the heart muscle can cause a wide variety of symptoms. As the heart becomes stiff it increases the pressure in the left ventricle which can push blood back into the lungs, causing shortness of breath in exercise. Chest pain can occur as there is not enough oxygen available to the cardiac muscle due to insufficient blood supply. Palpitations and lightheadedness, along with other conditions can occur as a result of HCM. In addition to these discomforting symptoms, the patient may develop an arrhythmias that often goes unnoticed. An arrhythmia takes place as the electrical conduction of the heart is disturbed by the abnormal scattering of myocytes. The two most common arrhythmias are atrial fibrillation causing palpitations, and ventricular tachycardia that can be life threatening causing sudden death. Both conditions can be controlled with medication. [4]

Symptoms do not occur until the advanced stages of the disease has occurred, such as your physician hearing a heart murmur, and performing tests. Symptoms include

Most physicians and people who acquired the problem usually know it as A-FIB, a shorter term for atrial fibrillation. Atrial fibrillation deals with the cardiovascular system, in particular, the heart in the body. It is defined as, “the electrical signals that control this system are off-kilter. Instead of working together the atria do their own thing, causing fast fluttering heartbeat, also known as arrhythmia” (WEBMD). In a normal pumping blood of the heart the atria would squeeze first, followed by the ventricles of the heart. A-fib can be a serious issue if not treated, due to the inadequate pumping of the blood, causing a higher chance of heart failure. It is also a higher chance in getting a stroke, because improper flow of the blood can cause clots in the

If the heart beats too fast, too slow or irregularly, it may not be able to pump enough blood to all of the body.

Dr. Arantza Manzanal explains how takotsubo was initially described “as a syndrome of reversible LV dysfunction with wall-motion abnormalities that involve the apical and midventricular segments” (57). Dr. Paolo Angelini rationalizes that “only during the last 2 decades have Japanese authors specifically categorized transient takotsubo cardiomyopathy (TTC) as an entity in itself. Before that time, TTC was often called “acute myocardial infarction with normal coronary arteries” (312). We will

Cardiac dysrhythmias come in different degrees of severity. There are heart conditions that you are able to live with and manage on a daily basis and those that require immediate attention. Atrial Fibrillation is one of the more frequently seen types of dysrhythmias (NIH, 2011). The best way to diagnosis a heart condition is by reading a cardiac strip (Ignatavicius &Workman, 2013). Cardiac strips play an chief part in the nursing world allowing the nurse and other trained medical professionals to interpret what the heart is doing. In a normal strip, one can clearly identify a P wave before every QRS complex, which is then followed by a T wave; in Atrial Fibrillation, the Sinoatrial node fires irregularly causing there to be no clear P

Today millions of Americans live or have lived with Atrial fibrillation. The main concern with this health issue is that many people who lived with it sometimes are not aware of it. Atrial fibrillation is defined by Mayo Clinic (2012) as “an irregular and often rapid heart rate that commonly causes poor blood flow to the body”. It occurs when the four chambers of the heart have a disrupted rhythm. The abnormal functionality of health may lead to a stroke because of the possible blood clot that will be formed. The Atrial fibrillation or Afib put the body in a situation without oxygen and nutrients because the body is not well supplied by a heart that is became weak. In general, only few people will feel change in their heartbeat. They may verbalize

Particularly heart beat irregularities (atrial fibrillation), disease of the heart valves, congestive heart failure or recent heart attack.

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Syncope is a common symptom of cerebral ischemia caused by various causes. The prevalence of inherited arrhythmias account for syncope is low. However, the syncope caused by inherited arrhythmias has possibility of indication of cardiac arrest and death and reported to be correlated with increased risk of sudden cardiac arrest. Long QT sy drome is a typical inherited arrhythmiacause syncope in children. Beta-blockers are clinically indicated in LQTS and effective for preventing recurrence of syncope. Brugada syndrome is also typical inherited arrhythmia cause syncope or sudden cardiac arrests in young individuals. The syncope is important for the risk stratification and therapeutic selection. Cathecolaminergic polymorphic ventricular

Brugada Syndrome was first described by brothers Pedro and Joseph Brugada in 1992. Nearly 30% of all BrS patients carry a pathogenic mutation in the SCN5A gene. The syndrome is thought to account for 20% of unexplained sudden death in the setting of a structurally normal heart and 12% of sudden cardiac arrest cases (Brugada et al 2014). Brugada Syndrome classified as a primary electrical disease is known to cause spontaneous ventricular fibrillation. When the arrhythmia occurs, it tends to be in the evening hours. This is thought to be due to increased nocturnal parasympathetic activity as part of the body’s natural circadian rhythm (Antzelevitch et al.

heart attacks, and strokes. Sometimes the heart beats so fast that it actually stops. Emergency

Without early intervention on average 360,000 people out of the hospital succumb to cardiac arrest. “ Cardiac arrest and sudden death account for 60 percent of all deaths from coronary artery disease”,(Bledsoe, Porter, & Cherry, 2011,2007,2004, p. 1229) [Click and drag to move] There are several causes of sudden cardiac arrest. Most are caused by ventricular fibrillation. “During ventricular fibrillation, the ventricles do not beat normally. Instead they quiver rapidly and irregularly.” When this occurs, the heart pumps very little and blood does not get circulated throughout the body. “ Most of the cases found with sudden cardiac death are related to undetected cardiovascular disease.("Sudden Cardiac Death," 2015, para. 2)Sudden cardiac arrest are immediate and drastic that includes sudden collapse, no pulse, not breathing, and loss of consciousness. “Four rhythms produce pulseless cardiac arrest: ventricular fibrillation, rapid ventricular tachycardia, pulseless electrical activity and asystole.”("Circulation ," 2005, p. IV-58)Other signs and symptoms that could occur prior to sudden cardiac arrest, include fatigue, fainting, blackouts, dizziness,

The presence of the arrhythmia is associated with significant impairment of quality of life, making an important contribution to general morbidity and mortality.24,301

In addition, scientists have found that genetics also plays a role in cardiac arrhythmias and that in some cases patients have commented that they had no symptoms before they succumbed to some form of episode of cardiac distress, like a sudden heart attack. This has proven to be standard for many different forms of arrhythmias, whether it’s due to genetics or not. One such case is the long QT syndrome (LQTS) which is estimated to affect one in every 5000 people and is recognized as a family disorder, frequent in children during their childhood years (Wilde, and Bezzina 1352–1358.) Patients with this disorder can have symptoms of a fluttering heartbeat, shortness of breath, and chest pain, while other patients might not experience any symptoms at all (Wilde, and Bezzina 1352–1358.) Another known disorder is cardiac conduction disease, which is mostly due to some form of cardiac injury (Wilde, and Bezzina 1352–1358.) Symptoms for this