Long Term Antibiotic Treatment Of Persistent Symptoms Attributed Lyme Disease
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The research question of this study was to determine if longer-term antibiotic treatment of persistent symptoms attributed to Lyme disease resulted in a better outcome than shorter-term antibiotic treatment1.
Evaluate the review of related research. How well did the authors provide a context for the current research in light of previous literature and gaps in current literature and knowledge? In the introduction, the authors indicate that previous randomized, clinical trials have not provided sufficient evidence to show the benefits of long-term antibiotic treatment versus short-term antibiotic treatment in patients with persistent symptoms attributed to Lyme disease. The authors do not explain the limitations of these previous studies…show more content… Thus, this study was ineffective in estimating the size of the treatment effect. In addition, the authors indicate that previous trials did not account for baseline difference in the quality of life for Lyme disease patients. The authors accounted for this by including the baseline quality of life as a covariate in the current study. This background information regarding previous studies would have been useful in the introduction in order to understand the context in which the study was performed and the reasoning behind the methods.
Identify the research design and assess threats to internal and external validity. The research design was a randomized, double-blind, clinical trial that compared short-term antibiotic treatment (ceftriaxone followed by placebo) and long-term antibiotic treatment (ceftriaxone followed by doxycycline or ceftriaxone followed by clarithromycin and hydroxychloroquine). The first two weeks in which all the subjects took ceftriaxone is referred to as the open-label phase and the following 12 weeks in which the subjects either took the placebo or the treatment is referred to as the randomization phase. The authors minimized selection bias by randomly assigning participants to either the placebo or treatment groups. This increased internal validity because it ensured that the groups had similar baseline characteristics by equally distributing potential confounding