Lung Cancer : A Malignant Cellular Transformation And Growth Of The Lung And The Airway Tissues

3080 Words Nov 10th, 2014 13 Pages
Lung cancer is a malignant cellular transformation and growth of the lung and the airway tissues. It is usually divided into two main types: Small Cell Lung Cancer (SCLC, 15%) and Non-Small Cell Lung Cancer (NSCLC, 85%) with the latter further subdivided into several subtypes such as Squamous carcinoma, Large Cell carcinoma, and Adenocarcinoma among other rare subtypes. Each subtype has its own unique growth and spread pattern with some being more aggressive than others. Lung cancer is staged according to the American Joint Committee on Cancer (AJCC) using the TNM system, where T stands for the size, N for nodal involvement and M for the presence of distant metastases. The knowledge of the lung cancer main types, subtypes and stage, and the presence of specific molecular and genetic signatures, help the clinician determine the appropriate treatment approaches be it surgical, radiation, chemotherapy and the combination of, in addition to the appropriate type of chemotherapy regimen. (SEER, ACS, AJCC, 2014)
Lung cancer has been the most common cancer in the world for several decades. The 2012 International Agency for Research on Cancer (IARC) estimate was 1.8 million new cases which constituted 12.9% of the total number of new cancers diagnosed worldwide. Fifty eight percent of which occurred in the less developed regions. Lung cancer remains the most common cancer in men worldwide (1.2 million, 16.7% of the total) with the highest estimated age-adjusted incidence rates in…

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