Case Study : Lung Cancer

What are lung cancers? Lung cancers are the abnormal cells which grow in uncontrolled manner in one or both lungs. They do not function as normal lung cells and do not develop into healthy lung tissue. The abnormal cells can grow, form tumours and interfere with the normal functions of the lung (Lungcancer.org, 2015). Lung cancers can be divided into two major types, namely non-small cell lung cancers (NSCLC) and small cell lung cancers (SCLC). NSCLC can be further classified into three main subtypes, namely adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma (Longo & Harrison, 2012). Lung cancers can be diagnosed by chest X-ray, computerised tomography (CT) scan, positron emission tomography-computerised tomography (PET-CT) scan, bronchoscopy and biopsy (Nhs.uk, 2015). Unfortunately, lung cancers are often diagnosed at the later stages. This is due to the unrecognisable symptoms and warning signs at the earlier stages. NSCLC are often diagnosed at stage IV which accounts for 30-40% of cases whereas 60% of SCLC is diagnosed at stage IV. Lung cancer usually originates from the cells lining the bronchi, bronchioles and alveoli. Carcinogens especially tobacco smoke will alter the gene expression of the normal human lung cells, resulting in cell mutation. The proto-oncogenes will be converted to mutated form, oncogenes. Mutation leads to the decreased expression of the tumour suppressor genes. This results in uncontrolled cell proliferation, cell

The human body is designed so that each part is dependent on the other for one or the other reason. There is a delicate balance to the distribution of functions and the way in which each system defenses itself against any unmentionable disease or ailment.

Lung Cancer is a disease which consists of uncontrolled cell growth in lung tissues. Lung cancer consists of two types, Non-small cell lung cancer, and small cell lung cancer. (NSCLC) is the most common type of lung cancer. The bronchi are the large air tubes leading from the trachea to the lungs that convey air to and from the lungs, and where most lung cancers begin. The body normally maintains cell growth only

Cellular / Molecular Basis: Lung cancer has two types; small cell and non small cell. The two types can be identified by their appearance when looked at with a microscope. It usually affects the cells that are lined along air passages in the lungs.

There are different types of lung cancers. NSCLC occurs when abnormal cells grow uncontrollably. The abnormal tissues multiply, and they form malignant tumors. The tumors can spread to other organs and tissues. Smokers have the highest rates of NSCLC. Prolonged exposure to radon can also cause NSCLC.

Patient stated that her siblings were born in a hospital. Mariano Saquilayan, grandfather, died at the age of 61 from lung cancer. Patient states that her grandfather smoked for a long time; therefore, leading to the result of lung cancer. Patient’s parents from her father’s side are diagnosed with diabetes, unknown of type (ages 80 and 77). Uncle on father’s side, Reynaldo Vinzon, developed diabetes at age 55; patient is unknown of type of diabetes. Patient’s uncle, Arnel Saquilayan, on her mother’s side is 55 years old and diagnosed with Polio and uncle, Manny Saquilayan, of 48 years old is diagnosed with heart disease. Patient is unaware of the type of disease. Patient’s parents both have hypertension and is currently taking medication for

SCLC is most regularly centrally situated tumour arising up from bronchial epithelium (Belinsky, 2004). Facts reveal 92% of patients had NSCLC, whereas 8% have been recognized with small cell carcinoma. The foremost commonplace anatomy changed into adenocarcinoma (43.8%) followed with the aid of squamous cellular carcinoma (26.2%), large cell carcinoma (2.1%) and others (8.3%). statistically better occurrence of the adenocarcinoma in non-people who smoke and small cellular and squamous histology had been more commonly located within the smokers [Noronha et al.,

Fig.42 :The tumor detection. A grade 2 periosteal chondrosarcoma in the humeral shaft. (A) Axial T2-weighted image before surgery. There is a small lesion hyperintense on the image (circle) in the posterior periosteum of the humeral shaft. (B) Axial diffusion weighted image. The tumor is hyperintense on DWI sequence (circle), easier to detect because of the high tissue contrast. (C) Axial T2-weighted image 6 months after the surgery. There is a very small residue of the tumor in the surgical site (circle), which is difficult to find on conventional MR imaging. (D) Axial diffusion-weighted image. The tumoral residue shows hyperintensity on diffusion-weighted image sequence (circle), which facilitates the detection. quoted from (Costa et al.,

It is wise, however, to have a doctor monitor the tumor over at least a two-years period in order to note any changes that might indicate the presence of cancer. Also, a biopsy or surgical removal of a tumor may be needed when the patient is a smoker, the patient has difficulty breathing, or other troubling symptoms, tests show that the cancer could be present, and the nodule continue to grow. The malignant lung cancer is divided into non- small cell lung cancer, small cell lung cancer, and lung carcinoid tumor. First, the non- small lung cancer is A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The cancer cells of each type grow and spread in different ways. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer. The first type of the non- small cell cancer is squamous cell carcinoma About 25% to 30% of all lung cancers are squamous cell carcinomas. These cancers start in early versions of squamous cells, which are flat cells that line the inside of the airways in the lungs. They are often linked to a history of smoking and tend to be found in the central part of the lungs, near a main airway (bronchus). The second type is larger cell carcinoma this type accounts for about 10% to 15% of lung cancers. It can appear in any part of the lung. It tends to grow and spread quickly, which can make it harder to treat. A subtype of large cell carcinoma, known as large cell, neuroendocrine carcinoma, is a fast-growing cancer that is very similar to small cell lung cancer. The third type of non- small cell lung cancer is adenocarcinoma about 40% of lung cancers are adenocarcinomas. that begins in the cells that line the alveoli and make substances such as

Cancer can be one of the hardest battles that one must face, whether that battle is lost or won, it changes the lives of everyone involved. Lung cancer is one of the most diagnosed cancers and it affects the lining of the lungs and the ability to breathe. Lung cancer is the number one killer of men and women than any other cancer worldwide. This cancer is mostly found in smokers and this is why professionals are targeting this population for testing for diagnosing early and possibly saving a life (www.ncb.nlm.nih.gov). Lung cancer refers to the malignancies that originate in the airways or pulmonary parenchyma.

Lung cancer is the leading cause of cancer-related mortalities in the world. An astounding average of 1.6 million deaths occur due to lung cancer yearly (1). Lung cancer is classified into two types: small cell and non-small cell lung carcinoma (NSCLC), where 85% of lung cancer cases are NSCLC. NSCLC has several different histologic subtypes, some of which are: squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Of the three, adenocarcinoma accounts for more than 50% of NSCLCs, making it the most common subtype (2).

Small cell lung cancer and non-small lung cancer can be differentiated by the biological and histological markers (Vescio, et.al., 1990). Among these two major types, non-small cell lung cancer is responsible for 85% of lung cancer (Lungcancer, 2015). Non-small cell lung cancer can also be divided into 3 common types since their spreading behaviors and microscopic structures are different. Those three are squamous cell carcinoma, large cell carcinoma, and lastly adenocarcinoma (NIH National Cancer Institute, 2015). Among these three, Adenocarcinoma accounts for 40% of NSCLC, and it is known as the most common types of

Nanotechnology has immense numbers of avenues and directions that have been created, especially in the treatment of cancer. It is only projected to become a bigger field that’s more accurate as time passes. But is nanotechnology sustainable and though accurate, strong enough to be the best cancer therapy system? Is lung cancer too difficult to treat with nanotechnology due to its metastatic tendency? And is nanotechnology the best direction that we could be following in our quest for the treatment of cancer without damaging other tissues? As we discover more technology and tools, problems pop up as quick as we can solve past ones – toxicological aspects of cancer treatment, cost effectiveness and the like. Can these wonder child molecules created

According to Mosby, cancer is a neoplasm characterized by the uncontrolled growth of cells that

Lung cancer is the leading cause of cancer deaths in Malaysia for both men and woman. Your lungs are two spongy organs in your chest. The left lung is divided into two lobes or sections, and the right lung has three lobes. When you breadth in air enters your nose or mouth and passes into your trachea or windpipe, at the carina the trachea divides into two bronchi then branches into smaller bronchioles. The bronchioles end in tiny air sacs or alveoli. In the alveoli the oxygen and the air you inhale passes into the bloodstream and carbon dioxide in your body passes out of the blood stream. The carbon dioxide is expelled from your body when you exhale. Your lungs are in cased by pleura, a thin membrane that protects them and helps them slide back and forth as you breathe in and out. Underneath your lungs is the diaphragm a smooth thin muscle that helps your lungs expand and contract as you breathe. Your lungs are connected to small collection of immune system cells called lymph nodes by way of lymphatic vesicles. You have groups of these lymph nodes near your lungs above your collar bones and behind your breast bone as well as in other parts of your body. Lung cancer is most commonly start in the bronchi, but they can also begin in the trachea, bronchioles, or alveoli.