Lung Cancer In The 20th Century: A Summary

What are lung cancers? Lung cancers are the abnormal cells which grow in uncontrolled manner in one or both lungs. They do not function as normal lung cells and do not develop into healthy lung tissue. The abnormal cells can grow, form tumours and interfere with the normal functions of the lung (Lungcancer.org, 2015). Lung cancers can be divided into two major types, namely non-small cell lung cancers (NSCLC) and small cell lung cancers (SCLC). NSCLC can be further classified into three main subtypes, namely adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma (Longo & Harrison, 2012). Lung cancers can be diagnosed by chest X-ray, computerised tomography (CT) scan, positron emission tomography-computerised tomography (PET-CT) scan, bronchoscopy and biopsy (Nhs.uk, 2015). Unfortunately, lung cancers are often diagnosed at the later stages. This is due to the unrecognisable symptoms and warning signs at the earlier stages. NSCLC are often diagnosed at stage IV which accounts for 30-40% of cases whereas 60% of SCLC is diagnosed at stage IV. Lung cancer usually originates from the cells lining the bronchi, bronchioles and alveoli. Carcinogens especially tobacco smoke will alter the gene expression of the normal human lung cells, resulting in cell mutation. The proto-oncogenes will be converted to mutated form, oncogenes. Mutation leads to the decreased expression of the tumour suppressor genes. This results in uncontrolled cell proliferation, cell

Throughout life, many individuals experience difficulties due to growing up in everyday life. While going in depth of the human life, it is discovered that there are many diseases and disorders that affect humans’ everyday functions. A very popular disease that has traumatically affected the human body is cancer. Cancer is a disease that spreads throughout your body in many ways. The purpose of cancer is to attach to a blood cell in your body and cause a plague within itself, causing the body to initially shut down and die. This disease contains many forms and have many causes to it. However its main goal is to destroy the human body.

The human body is designed so that each part is dependent on the other for one or the other reason. There is a delicate balance to the distribution of functions and the way in which each system defenses itself against any unmentionable disease or ailment.

The leading cause of cancer death for both men and women in the United States and worldwide is lung cancer. Lung cancer is responsible for thirty percent of cancer deaths in the United States. The deaths caused by breast cancer, colon cancer and prostate cancer combined do not add up to the deaths that lung cancer causes. In 2007, 158,683 people, 88,243 men and 70,354 women died from lung cancer in the United States (Eldridge, 2012). Out of the 158,683 people that died from lung cancer in 2007, 135,000 of them died of lung cancer caused by smoking cigarettes. The overall survival rate of those with lung cancer is at about fifteen percent.

Lung cancer is a genetic and acquired disease. Lung cancer is genetic because cancer in general is caused by changes to the genes that control the way our cells function, especially how they grow and divide. All of these changes include mutations in the DNA that makes up our genes. Genetic changes that increase cancer risk can be inherited from our parents, if the changes are presents in germ cells. Which are the reproductive cells of the body, those are the eggs and the sperm. Lung cancer is also acquired because as the result of errors that occur as cells divide a person’s lifetime or exposure to certain chemicals. Some examples of these chemicals are found in tobacco smoke, radiation, UV rays from the sun that damage DNA. “In general, cancer cells have more genetic changes than normal cells. But each person’s cancer has a unique combination of genetic alterations.” Some of these changes may be the result of cancer, rather than the cause. As the cancer continues to grow, additional changes will occur. Even within the same tumor, cancer cells may have different genetic changes.

Lung cancer is a tumor that affects either one or both of the lungs.A primary cancer begins in the lungs and a secondary cancer begins in another place in the body and makes its way up towards the lungs. Lung cancer is the 5th most common cancer. In Australia 59% of males were diagnosed were as 41% of Australian females were diagnosed.

This paper discusses in distinct detail the pathology of lung cancer, specifically malignant tumors. This investigation into the cancer touches on many different subjects that include: the history of the disease and how it came to be so prevalent, it’s cellular origins, how it is diagnosed within a patient, the different treatments used to fight it, and the survival rates for people with any sort of lung cancer. The paper also goes in depth about the use of x-rays and how they are used to find lung cancer. There are many resources used for this paper and they are cited as necessary.

Lung Cancer is one of the most deadly types of cancer. ?Lung cancer kills more Americans than the next five cancers combined? (Jameson). Lung cancer can be caused by smoking, second hand smoke, pollution, and chemicals. ?Some symptoms of lung cancer may be someone who has a cough that doesn?t go away or gets worse, chest pain that is often worse with deep breathing or coughing or laughing, hoarseness, weight loss and loss of appetite, coughing up blood or rust- colored spit, shortness of breath, felling tired or weak, infections such as bronchitis and pneumonia that don?t go away or keep coming back, new onset of wheezing, and often showing no symptoms until it?s too late? (Ungar). Chronic obstructive pulmonary disease is a risk factor for developing lung cancer, and have a poor chance of treatment after having lung cancer. People don?t know cancer can kill them. There four stages of lung cancer one through four. . The four stages of lung cancer are in stage one the cancer is only in the lungs and nowhere else yet. In stage two the cancer is in the lungs and is moving nearby the lymph nodes. The third stage of lung cancer has spread to the middle of the chest. In the last and final stage of cancer is the worse of them all it has went into both lungs and fluid around the lung or to other parts of the body such as organs or liver

Lung cancer is the leading cause of cancer-related mortalities in the world. An astounding average of 1.6 million deaths occur due to lung cancer yearly (1). Lung cancer is classified into two types: small cell and non-small cell lung carcinoma (NSCLC), where 85% of lung cancer cases are NSCLC. NSCLC has several different histologic subtypes, some of which are: squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Of the three, adenocarcinoma accounts for more than 50% of NSCLCs, making it the most common subtype (2).

Lung cancer is the number one cause of death by cancer. It has affected my family tremendously. My grandma was diagnosed with stage four lung cancer in June of 2014, it has been almost two years and she is still fighting. She has gone through so much and it really takes a toll on your body. She has gone through years of chemotherapy, radiation, so many drugs and recently was put on oxygen that she needs 24/7. I pray every day that people will stop smoking and not take the risk of developing lung cancer.

When I was 14 I was staying in a double room in Memorial with another girl. She was 16 and had lung cancer, which at this point was quickly spreading to the rest of her body with the doctors at a loss on how to stop it. Her name was Melissa and we very quickly became friends. She was checked in about 3 weeks before I arrived, and it certainly didn’t seem like she was leaving anytime soon, despite how badly she protested that how she was living wasn’t actually living. We didn’t really talk much the first couple of days I was there but on the fifth day she asked me the most asked question among patients in hospital, “So what are you in here for?”

I remember it was a December evening, when my parents and I had just gotten back from the Nutcracker Ballet when they called to tell us that my Grandma had passed away in her sleep. My Grandma had been staying in California with my Aunt Cindy for over six or seven months, and she had been staying in a hospital bed since soon after she got to California because she was very ill with lung cancer. It made me feel very sad to think about her dying.

(Transition: we have discussed the causes, lets look at the risk factors including some environmental ones.)

When we are young, we never think about anything bad happening. We always imagine our parents living forever and taking care of us. We didn’t understand why everyone was sad at a funeral. We didn’t react like adults do when something bad happens. Children aren’t programmed to think the worst of things normally. They’re lucky. When a certain age comes along, reality really slaps you in the face and everything kind of crumbles down. The tragedies of life really make it hard to remember when things were simpler.

Introduction: Lung cancers are well known to display inter and intra-tumoral heterogeneity with profound implications for exact histological classification by pathologists1–3. The New International (IASLC/ATS/ERS )4,5 and the 2015 World Health Organization (WHO) classification6 has defined the non-invasive (adenocarcinoma in situ), minimally invasive adenocarcinoma and invasive lepidic adenocarcinoma ; has replaced the 'mixed subtype category ' in the WHO 2004 classification7 with the predominant subtype ; included the micropapillary subtype8,9 and replaced the term “mucinous bronchioloalveolar carcinoma(BAC)” with invasive mucinous adenocarcinoma. This study aimed to do a comprehensive histological subtyping and detailed study of