Because no single measure can describe status in all SLE patients, standardized indices for assessing SLE disease activity have been created. In addition To the Physicians’Global Assessment (an estimate of activity rated on a 0 to 3 visual analog scale), the most common measures used include the SLE Disease Activity Index (SLEDAI), the British Isles Lupus Assessment Group (BILAG), the Systemic Lupus Activity Measure (SLAM), the Lupus Activity Index (LAI)68,70, and the European Consensus Lupus Activity Measurement (ECLAM). All of these indices are valid, reliable, and comparable. Some of them are easy to incorporate into routine clinical care, giving a quick snapshot of a patient’s status70. The SLEDAI is perhaps the easiest assessment tool to use. Twenty-four …show more content…
How to sense lupus flare from symptoms71
The following are the clinical features which are can be considered as a warning of impending flare: Increasing fatigue Arthralgias and myalgias New or worsening rash
Persistent headache
Fever
Abdominal pain.
Renal Flare
Nephritis is characterized by peripheral oedema secondary to hypertension or hypoalbuminemia During flare, the WHO histopathological class changes to a higher level with additional features of activity or chronicity. Basic haematological profile reveals anaemia,
ESR and thrombocytosis. Urine examination will show proteinuria, increased WBCs, haematuria and casts. Complement levels fall.
Haematological Flare
Acute immune haemolytic anaemia with a sharp fall in haemoglobin (>3gm), spherocytes on peripheral smear, raised bilirubin and reticulocyte count and a positive Coomb’s test confirm haemolytic process. Leucopenia and lymphopenia correlate with disease flare
Thrombocytopenia may be due to antiplatelet or antiphospholipid antibodies(APLA).
. Central Nervous System (CNS) flare
The ACR criteria for NPSLE have been mentioned in clinical manifestations of CNS lupus.
(Measureable) quality is being measured by scores (areas are being identified by scores of either higher or lower)
For every case of Lupus there is always a different set of signs and symptoms. “ No two cases of Lupus are ever the same. Symptoms can have a very wide range.” (Mayo Clinic Staff)
Discoid Lupus Erythematosus (DLE)is an autoimmune disease that affects the skin, DLE causes skin rashes and lesions on the scalp, internal ear, nose, and cheeks, unfortunately, hair loss and skin pigmentation occur with this disease. This rare disorder seems to be more common in women (between the ages of 20-40) than in men and is hereditary. Ten to twenty percent of people (around 200,000 US population) who have DLE will develop its more severe cousin ASLE (acquire systemic lupus erythematosus) which can be life threatening.
Elsa lives in the North of England. After she found out she had Lupus for a period of six years, the doctor consultant advised her that her pregnancy was safe. In 2008, following the birth of her daughter, her kidney malfunctioned. She had not known the impact of the disease on her life. She says that the illness made her long hair thick, which gradually fell off her head. This traumatized her also because of the way people treated her when they learnt she was suffering from Lupus. Elsa felt so damaged physically and physiologically, and made her feel uncertain of plans of having more children. Her future seemed unpredictable (Samsom, 2010).
What is Lupus? Lupus is an autoimmune disease in which our autoantibodies target self-proteins, known as ANAs. Systemic Lupus Erythematosus (SLE) is understood to be caused by our genetics and the environmental triggers from our everyday lives. There are four different types to this incurable but manageable disease, Cutaneous Lupus Erythematosus, Drug-induced Lupus Erythematosus, Neonatal Lupus, and Systemic Lupus Erythematosus. I will cover all of them, the main focus is on Systemic Lupus Erythematosus which is commonly diagnosed in females.
Lupus is a disease that can destroy any and every part of your body, for instance, your skin, joint, and even your organs. Lupus is a very tricky disease and no one knows what the cause of it is, the body natural defenses system is the immune system and with lupus, the immune system attacks healthy tissues instead of attacking only the damaged tissues. For example when you get things like a bacteria and viruses the body will kill both good and bad cells because it can’t tell the sick cells apart from the healthy cells. People who suffer from this disease experience a lot of pain. The disease is lifelong and has no cure however most people with lupus can control the symptoms and prevent severe damage to their organs. African American women are
The assessments appropriate the above activities include documenting of standards and skills whereby the teacher records through child-generated products, anecdotal records, notes, and observation. The teacher will carry out this assessment throughout each day to monitor the children’s progress towards accomplishing focus skills, fine motor skills, and gross motor skills throughout the week. The teacher will also assess the children using authentic assessment, such as observing, listening, and recording.
Discoid lupus erythematosus (DLE) is a chronic, scarring, atrophic, photosensitive dermatosis. DLE may occur in patients with systemic lupus erythematosus (SLE), and <5% patients with DLE progress to SLE. The primary lesion is an erythematous papule or plaque with slight-to-moderate scaling. As the lesion progresses, the scale may thicken and become adherent, and pigmentary changes may develop. Patients with DLE rarely fulfill four or more of the criteria used to classify SLE. Serologic abnormalities are uncommon. Therapy with sunscreens, topical corticosteroids, and antimalarial agents is usually
Systemic Lupus Erythematosus is a very rare and severe autoimmune disease. While the symptoms vary, lupus commonly affects the skin, joints, and mucous membrane (Brown, Bond, & Waldron, 2014). However, systemic lupus erythematosus (or lupus, for short) can become a multi-organ disease resulting in further complications. Because lupus is so rare and the symptoms vary, diagnosis is difficult and often does not occur until the disease is in its latter stages. However, in the detection of the disease, Brown, Bond, and Waldron (2014) express the importance of noticing certain common symptoms in young females, which are severe fatigue, mouth ulcers, headaches, rashes (especially those caused by the sun), and flitting arthralgasis (joint pain) and
There are many varieties of lupus, but the most common one is Systemic Lupus Erythematous (SLE). SLE, commonly referred to as lupus, is a chronic autoimmune inflammatory disease that can affect all of the organs. There has not been a lot of research on this disease, but much of what is known about SLE is based on the signaling of the molecular abnormalities that is present in the disease (Signaling). It is believed that the cause of this disease is genetic, and triggered by unknown environmental stimulus. Although this disorder can occur in person, it is most commonly found among both African American men and women, especially women between the ages of fifteen and forty-five.
When I was 14 years old I almost died. I grew sick because I had Systemic Lupus Erythematosus. Only no one knew until it was nearly too late. I was later hospitalized and diagnosed. I came out of the hospital directionless, yet anxious; I had a weight of unplaced responsibility on my shoulders.
Kristan is a 49-year-old female who suffers from systemic lupus erythematosus (SLE) (M32.19), along with osteoarthritis, vitamin D deficiency, CVA, and anemia. Her symptoms include fatigue, joint pain, swelling, morning stiffness, rash, sleep disturbances and fever. Kristan has tried and failed various treatments including quinacrine, prednisone, and plaquenil, all provided her with little to no relief. Systemic Lupus Erythematosus (SLE) is the most common form of lupus, a chronic, incurable autoimmune disease producing autoantibodies that can attack almost any system in the body. Lupus can impact the lives of patients in many different ways with varied and often unpredictable symptoms. Benlysta is currently the only medicine specifically
It’s the first time that I really think in stars and constellations. I see them all the nights but today was the first day that I look for a real meaning in those bright points in the sky. For my essay I choose the constellation “Lupus” and the reason it’s very easy, i love animals and wolf is one of my favorites. This constellation is situated in the south hemisphere between two others, Centaurus and Scorpius. In addition it’s not a big constellation; it is composed by thirty not very bright stars.
“Inflammation is a localized tissue response to injury. Inflammation produces local redness (rubor), swelling (tumor), heat (color), and pain (dolor). These are known as cardinal signs and symptoms of the inflammation. Sometimes a fifth is included: lost function (function laesa) (Martini, 2015, p. 801). The normal physiology of inflammation is its “response to a defense mechanism that evolved in higher organisms to protect them from infection and injury. Its purpose is to localize and eliminate the injurious agent and to remove damaged tissue components so that the body can begin to heal” (“Inflammation”, 2017, para.1). Inflammation is indicative of injury and maybe even possible disease. The anatomy of inflammation is a “change in blood