MD Anderson Liver Summary

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The MD Anderson Liver Tumor biospecimen resource has been invaluable for a large number of studies or clinical development. The sixth and subsequent editions of the American Joint Committee on Cancer (AJCC) staging of hepatocellular cancer, which was developed by an international consortium led by Jean-Nicolas Vauthey, MD, Professor of Surgery at MD Anderson and co-leader on project 2 of the SPORE, was based upon pathologic review of resected specimens in the Liver Tumor Bank (Vauthey JN J Clin Oncol 2002 20:1527-36). In addition, investigators at MD Anderson examined tissues in the Liver Tumor Bank to elucidate the prognostic significance of the ribonucleoprotein Human Antigen R (HuR) showing that patients with high HuR tumor expression had…show more content…
Cases are defined as patients with newly and pathologically diagnosed HCC who were referred for treatment at MD Anderson Cancer Center. All participants had to be residents of the United States and could not have had a prior history of other cancers. We included all referred HCC patients with no restriction to age, sex, and race. Patients who agreed to participate in the study signed informed consent documents indicating their willingness to be personally interviewed for 45 minutes to provide detailed history of smoking, alcohol, occupational, chronic medical diseases, hormonal, and family history of cancer. Patients provided answers to detailed diet “food frequency questionnaire” prior to cancer development. They also provided blood samples for viral, biomarkers and genetic testing. All data is securely documented in password protected database. Diet questionnaire are currently being analyzed through a collaboration with Harvard University for macro- and micronutrient analysis. Upon enrollment, the complete clinical picture of HCC at the time of diagnosis (Baseline) are retrieved. Under IRB approval
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