MMP-A Case Study

The defective genes job to identify and repair somatic mutations in DNA during cell division was later referred to as microsatellite instability. It was identified in a number of genes through screenings of blood tests. This microsatellite instability lead in some cases to loss of imprinting, but further research is need to determine if this loss of imprinting in healthy people will lead to the development in cancer. A study done in 1997 revealed that the microsatellite instability in genes p53, RAS, and APC fit 85% of colon carcinomas, many of which were aneuploidy and all sequential mutations of those genes. The rest were deficient in DNA mis- match repair genes which tended to have near diploid genotypes. This study was tested with cultures, it is now being tested with clinical specimens.

The Maryland Personal Information Protection Act (MPIPA) was enacted to help ensure that Maryland consumers’ personal identifying information is reasonably protected, and in the case of a breach, the consumer is notified so that they can take measures to protect themselves. While it has provided many essential safeguards, Maryland can take a step towards more robustly protecting itself and its citizens by amending and expanding certain provisions of the MPIPA.

MMP-9 is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix and have an important role in cancer progression. VEGF is a protein produced by cells that stimulates angiogenesis. It restores the oxygen supply to cells when blood circulation is inadequate and also similar to MMP-9 causes to cancer

It appears that the clone of antibody used, influences the TTF-1 expression in tumors.(35, 36) Although TTF-1 was thought to be a specific maker for lung adenocarcinomas, positive staining with IHC for adenocarcinomas of other origin became

CYP1A1*2A genetic variations have been indicated to raise risk for several cancers, such as cervical cancer, lung cancer, prostate cancer and laryngeal cancer(49,50,51,52). However, poor relations between polymorphic CYP1A1*2A and gastric cancer, colorectal cancer, esophageal cancer and breast cancer risks have been found (53,54,55). Therefore, polymorphism of CYP1A1 MspI might play different roles in different cancers.

While working on the MRAP (Mine Restraint Ambush Protected) program for the Army, I came across a difficult issue to overcome. The main parts supplier did not have the proper paperwork filled out or even submitted for the company to even ship parts overseas let alone to a combat theater of operations. Rather than just sit around and wait for the shipping company to get all the paperwork filled out and submitted I called a meeting with all the leaders at the time and discussed the issue at great lengths. I brought up the idea of doing an end around the current shipping company by having myself fly the parts personally into theater. This way the parts would not have to go through customs but only the airline check point. I called the shipping

To determine whether MGMT and ERCC1 DNA methylation is diagnostic of human cancer rectum, we detected the frequency of MGMT and ERCC1 methylation in 50 serious of primary cancer rectum samples and 43 benign rectum tumors by MSP. MGMT and ERCC1 were methylated for 13.9% and 18.6% in the benign tissue and for 4.7% and 7% in the blood, respectively. On the contrary, a methylation-positive pattern of MGMT and ERCC1 was observed for 80% and 74% of cancer rectum tissues and for 58% and 60% of the blood, respectively. The differences in the frequencies of MGMT and ERCC1 methylation pattern between rectum cancers and benign tumors was statistically significant (p<0.001 for each in the

DMRP will be following AFMAN 23-3 Sec 26.5.2.2 guidance "...provide travel funds to support GIDEP workshops, seminars, and clinics..."). GIDEP only provides training and workshops at conferences and symposiums to support participation. The DoDI 4140.67 mandates all suspect counterfeit and counterfeit information be posted to GIDEP. The DMSMS conference is where DMRP team will receiving training for all things counterfeit.

Other methodologies for integrative genomic analysis in cancer have been studied previously. The review presented in \cite{kristensen2014principles} summarizes a number of different tools and algorithms used in this area. The paper classifies these methods into statistical, machine learning, gene set, network, and other analysis techniques.\\

Both early genes E6 and E7 are responsible for the progression of cervical cancer oncogenesis [2][4]. These two genes have many different actions but discovered first was the interaction that E6 had with p53 and how E7 interacts with RB, both genes will initially alter host metabolism to favor abnormal cell development [4][7]. By degrading host p53, the host cell can no longer initiate apoptosis upon infection [7]. P53 and RB have crucial roles in the cell maintainence of the cell cycle specifically at the (G1/S-phase checkpoint) [7]. Explain their role and importance in cell processes.

6 different types of Mll family proteins have been identified in humans one of which is Mll1 (Morgan and

P16 is a tumor suppressor protein, which in humans is encoded by the CDKN2A gene. The protein has a key job in regulating the cell cycle. It helps to decelerate cell progression from G1 phase to S phase, so it acts as a tumor suppressor that is linked to the prevention of cancers, particularly cervical cancer, esophageal cancer, and melanoma. P16 can be helpful to increase the histological diagnostic precision of cervical intraepithelial neoplasia, which is a possibly premalignant transformation and atypical growth of squamous cells on the surface of the cervix. In a multitude of tumors, the CDKN2A gene is deleted or mutated. P16 also inhibits cyclin dependent kinases like CDK6 and CDK4. These kinases help phosphorylate retinoblastoma protein

DETERMINATION OF THE HYPERMETHYLATION OF SELECTED TUMOUR SUPPRESSION GENES IN SALIVARY GLAND TUMOUR AND ITS ASSOCIATION WITH HPV POSITIVITY.

Gynecological cancers continue to be an important health problem worldwide.[1] Gynecological cancers accounts for 1/3 of entire female malignancies. [2] Cervical, endometrial and ovarian cancers are the leading types of gynecologic cancers. While Vulval, vagina, fallopian tubes and choriocarcinoma are less frequent sites for female genital malignancies. [3] Worldwide incidence and mortality rates (per 100.000) of gynecological cancers are respectively as follows: cervical cancer 16.1 and 7.99, endometrial cancer6.4 and 1.5, ovary and other gynecological cancers 6.5 and 3.8. [2]

In the article, “Reliability and Validity of the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) in Evaluations of Chronic Low Back Pain Patients,” by Tarescavage, Scheman, and Ben-Porath (2015), the writers aim to determine whether or not the MMPI is able to be a valid and reliable measure in predicting chronic pain in low back pain patients. Several methods were used in this study in order to investigate the hypothesis that the MMPI was a valid and reliable measure in predicting chronic pain in patients with low back pain. Using a sample of patients from a rehabilitation center, the investigators were able to calculate correlations between the MMPI’s scales, collateral medical records, and the participants own self report. The results of this article indicated that indeed the MMPI proved to be both valid and reliable in predicting chronic pain.