Madding Blood To Clot Research Paper

Haemostasis is a normal physiological process to stops bleeding and maintains blood in the fluid state.

According to the National Hemophilia Foundation (.n d.), people with VWD experience recurrent nosebleeds, easy bruising and extreme bleeding for the duration of and after invasive procedures, such as tooth removals and surgery. Women often experience menorrhagia, heavy menstrual periods that last lengthier than usual, and hemorrhaging after giving birth. The signs and symptoms depends on the severity of the disease.

As the best of my knowledge I believe the two year old child is suffering from an inherited disorder called hemophilia. The Mayo Clinic describes hemophilia as a rare blood disorder that lacks sufficient blood clotting proteins. (Staff, B.M. ((n.d.)). Hemophilia. Retrieved September 27, 2016, from http://www.mayoclinic.org/disease-conditions/hemophilia/basics/treatment/con-20029824

We depend on our blood's ability to clot for survival. Without clotting ability, we couldn't heal, and the most minor injury could cause massive bleeding. Clotting is necessary, but in some cases, it is a necessary evil, as it also clots in dangerous ways, resulting in heart attack, stroke and other major problems. Some

Hemostasis will begin immediately after the injury to the knee. Hemo=Blood and Stasis=stopping/keeping. There will be three sequences of events occurring during this “stop bleeding” event: Mechanism 1) Vascular Spasm (squeeze step---blood vessels around the wound will constrict to bound blood escape) Mechanism 2) Formation of a platelet plug (known as the plug step whereby platelets come to the scrapped area of knee and adhere to exposed collagen fibers 3) Blood clotting (Coagulation phase ---Coagulation cascade converts inactive proteins to active forms and blood clotting begins)

The blood clotting process known as the coagulation cascade is complex and sophisticated which involves a multi-step. The coagulation process does more durable repairs of the vessel and very essential for closing up larger wounds and maintaining the platelet plug which allows for the formation of thrombus, or clot to form. The cascade process of coagulation is chain reaction because one step leads to next events. In each step of cascade produces a new protein of enzymes or catalysts. The Coagulation cascade leads to three different pathway an intrinsic pathway or an extrinsic pathway and at the end both of which lead to a common pathway. There are 12 known clotting factors involved in three different pathway of coagulation cascade including

Individuals with hemophilia may have a mild, moderate, or severe form, although the severe form is more prevalent. Individuals with hemophilia will bleed longer than others would. “Bleeds can occur internally, into joints and muscles, or externally, from minor cuts, dental procedures or trauma” (National Hemophilia Foundation, n.d., para. 7). Mild hemophiliacs may experience excessive bleeding only after a significant injury or procedure (National Hemophilia Foundation, n.d., para. 8). Individuals diagnosed with moderate hemophilia may experience bleeding episodes after both minor and serious injuries and have few spontaneous bleeds (National Hemophilia Foundation, n.d., para. 8). Severe hemophiliacs are prone to profuse bleeding after an injury and spontaneous bleeding episodes that appear to have no cause (National Hemophilia Foundation, n.d., para.

You mentioned hemophilia so I just wanted to explain what it was. Hemophilia is an inherited disease that affects the clotting process of your blood. Therefore, if you have hemophilia you do stand a chance of sever bleeding if you incur an injury or cut. There is a protein that is called clotting factor that a person might have little or none at all. It is a protein used for blood clotting that helps blood platelets stick together. (NIH

Hemophilia is a rare disorder when blood doesn't clot normally because it is short on sufficient blood-clotting proteins. Deep bleeding inside the body is big concern especially in the knees, ankles and elbows. The internal bleeding caused from this can damage the organs and tissues of the body and may be life threating. When a person without Hemophilia is injured, a system of procedures happens to make the blood turn from liquid to solid to clot the wound and make the blood flow stop. Platelets, which are cells found in the blood, combine together to form a clot at the site of bleeding. The platelets hold an enzyme that causes fibrinogen to change to fibrin which is a solid substance that doesn’t liquefy. The fibrin goes to the area of injury

Haemophilia is an inherited blood clotting disorder where the blood doesn’t clot properly because there isn’t enough clotting factor VIII or IX in the blood of someone who is affected by haemophilia (ref). There are two types of haemophilia. The most common form, Haemophilia A, or Classic Haemophilia, affects people who are deficient in factor VIII and Haemophilia B, or Christmas Disease, affects people who are deficient in factor IX. Haemophilia can also be referred to as ‘the royal disease’ because it affected royal families in England, Germany, Russia and Spain in the 19th and 20th centuries. Queen Victoria from the English royal family is believed to have carried the altered gene of haemophilia having a factor XI deficiency. In Australia there are approximately 3000 people affect by haemophilia and majority of them are males, with severe haemophilia extremely rare in females, but some females do have lower factor levels and bleeding symptoms. Abnormal bleedings had first been recorded hundreds of years ago, but wasn’t announced publicly until 1803 when a physician from Philadelphia, John Conrad Otto, published an article about a hemorrhagic bleeding disorder that affect mainly males.

Hemophilia is an inherited bleeding disorder that is passed from mother to son. This affliction is passed in such a way due to the fact that the gene that is responsible for hemophilia is carried on the X chromosome that the child receives from his mother. For someone to be afflicted by hemophilia means that their blood has a difficult time clotting. There people do not bleed any faster than the average person, they simply cannot stop bleeding once they start bleeding. As of this current moment, there are no known cures for hemophilia, but there are many treatments that are highly effective in helping to treat many of the issues associated with the bleeding disorder. (citation)

Blood is essential to human life. It carries oxygen, nutrients and hormones all through your body with a strong pump from the heart. Steven’s inability to stop bleeding could be detrimental to his health. There are many bleeding disorders existing today but the main, most common ones are limited to hemophilia A, hemophilia B, and von Willebrand disease. Von Willebrand disease is carried on chromosome 12 and occurs equally in men and women, unlike hemophilia which is an x linked disorder typically affecting males more often. There are many other rare forms of hemophilia with deficiencies in clotting factor 1, 2, 5, 7, 10, 11, 12, and 13 but type A and B specifically involve defective genes relating to factor 8 and 9, respectively. Through the

Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.

Hemophilia is an abnormal, rare disorder caused when blood does not properly clot, due to a lack of certain proteins. This disorder is genetic and is inherited from the parents of the offspring. Hemophilia does not change a humans lifestyle if it is treated correctly and the person is healthy and active. When a person bleeds, the body automatically forms a clot to stop the bleeding by sealing the blood cells together. Hemophilia occurs when blood particles do not participate in the clotting factors.

Hemophilia is a problem with the blood in a person that causes them to bleed not any faster than normal, but they often bleed for a longer period. Their blood is missing the clotting factor (a protein in the bloodstream that works to control bleeding). Hemophilia is quite rare; roughly 1 in every 10,000 persons are born with it. Rarely, hemophilia can be an acquired disease which just means a person is not born with it, but will develop it during their lifetime. This rarity occurs when a person's immune system forms antibodies that attack the clotting factor in the blood. The entire antibody population fights against the blood to prevent the clotting factors from working properly.