Magnesium In Exacerbation

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Role of serum magnesium in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Arunkumar Sreekumar1, Velayudhan K.K.1, R.N. Sharma1.

1. Department of General Medicine, Amrita Institute of Medical Sciences,
Amrita Vishwa Vidyapeetham.


Background: Chronic Obstructive Pulmonary Disease (COPD) is defined as a chronic airflow obstruction that is progressive and only partially reversible. Today COPD is recognized as a major killer disease and the fourth most common cause of deaths in U.S.A. Available data suggest there are more than 12 million adults with COPD affection in India with estimated prevalence rates of 2.12% to 9.4% in north India and 1.4 % to 4.08% in Southern India1. Many studies have indicated that magnesium deficiency has contributed to exacerbation in COPD and that the treatment with intravenous magnesium in these patients helps in relieving bronchospasm by
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Materials and Methods:A prospective study was conducted at Amrita Institute of Medical Sciences, Kochi, Kerala. Our study made use of an observational model, the case control study, to possibly explore and confirm the association between serum magnesium levels and its influence over exacerbation of COPD as compared to those at stable COPD conditions. The study was done on 100 patients who were previously diagnosed with COPD.

Results: The mean magnesium values of stable COPD patients in our study averaged 2.08 and 2.06mg/dl for patients below and above 60 years of age respectively. Their corresponding mean scores during exacerbation were 1.58 and 1.6 mg/dl respectively, which is significant.

Conclusion: There exists a significant role of magnesium during COPD exacerbation, as compared to when they are stable.

Key words:
Exacerbation,COPD (Chronic Obstructive Pulmonary Disease), Serum Magnesium, Peak Expiratory Flow Rate, Stable COPD, Oxygen
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