Magnetic Resonance Imaging Studies in Bipolar Disorder and Schizophrenia

730 Words3 Pages
Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis D. Arnone, DM, MRCPsych, J. Cavanagh, MD, FRCPsych, D. Gerber, MRCPsych, S. M. Lawrie, MD, FRCPsych, K. P. Ebmeier, MD, A. M. McIntosh, MD, MRCPsych Several magnetic resonance imaging (MRI) studies have determined structural abnormalities in association with bipolar disorder. The literature is, however, incongruous and there remains ambiguity about which areas of the brain are crucial to the pathogenesis of the ailment. The aim of this article is to identify, appraise and summarise volumetric MRI studies of brain regions comparing bipolar disorder with an unrelated control group and individuals with schizophrenia.The method applied was a systematic review and random-effects meta-analysis that was carried out to determine main areas of structural aberrancy in bipolar disorder and ifr the pattern of areas affected disconnected bipolar disorder from schizophrenia. The results of the study of participants with bipolar disorder are delineated by whole brain and prefrontal lobe volume reductions. In comparison with schizophrenia, bipolar disorder is affiliated with smaller lateral ventricular volume and extended amygdala volume. Heterogeneity was widespread the partial explanation for this is by clinical variables and the year it was published. Appearance of substantial differences in brain volume in bipolar disorder compared with healthy volunteers is present. Most changes do not seem to
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