Major Types Of Major Depressive Disorder Essay

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Major depressive disorder is a mental illness characterized by five or more of the following symptoms that have been present during the same 2 week period.29 These symptoms include; depressed mood, diminished interest or pleasure, fatigue, insomnia or hypersomnia, feelings of guilt or unworthiness, significant weight gain or weight loss change, and poor concentration.29 These symptoms cause significant distress or impairment in social, occupational, or other important areas of functioning. They can be long lasting or recurrent. Furthermore, depression is the leading cause of disability for people ages 15 to 44. and it is a major cause of disability in people ages 15 to 44.30 Majority of them are women compared to men. Thus, in a greater aspect, this disorder affects about 6.7% of people a year.30 Other than the psychological dimension of the disorder affected by early life traumas and/or stressors, the biological etiology involves the depletion of neurotransmitters, such as serotonin and norepinephrine. The “older perspective” suggested that there was a ypo functioning of serotonergic, noradrenergic, and/or dopaminergic pathways. Now it is seen as mediated by a common pathway that is yet to be defined. These monoamines influence this pathway by affecting gene expression and function. By affecting gene expression and function, it plays a significant role in the response to antidepressants. Specifically, the pathways that may play a role include glutamatergic
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