Malignant Hyperthermia

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Malignant Hyperthermia Malignant Hyperthermia is primarily thought to be an autosomal dominant genetic disorder that causes a hypermetabolic state after administration of volatile anesthetics. When a patient is under anesthesia, the muscles are usually relaxed, but when a patient is experiencing Malignant Hyperthermia crisis, certain IV anesthesia causes the opposite effect. Most inhaled anesthetics other than nitrous oxide, cause or trigger Malignant Hyperthermia. More specifically, the anesthetic agents: Halothane, Chloroform, and Succinylcholine. The genic condition of Malignant Hyperthermia only becomes apparent when a patient is exposed to certain anesthetics such as halothane, which causes muscle rigidity.…show more content…
An increase in calcium inside muscle cells activates processes that generate heat and production of excess acid, leading to a continual increase in body temperature and then acidosis. Our cardiac muscle remains unaffected in those with Malignant Hyperthermia because this condition is within the skeletal muscles. Here, the brain sends electrical signals that eventually reach the calcium pump and cause a domino effect. There are minimal proven theories about Malignant Hyperthermia’s effect on the cardiac muscle by professionals; however, what is known, is that during a Malignant Hyperthermia crisis, there are increased abnormal heart rhythms frequent in this disorder. These arrhythmias are often attributed to the damage made directly to the cardiac muscle. Malignant Hyperthermia can be fatal by causing stable blood pressure to drop tremendously and heart rates to rise excessively. Malignant Hyperthermia can also cause kidney and liver failure. Because Malignant Hyperthermia causes the muscle cells to deteriorate, releasing an excessive amount of potassium, acid, and protein into the blood, it disturbs the body’s chemical balance. The kidney's shut down which prevents the body from producing urine; the liver ceases to detoxify the body's waste products, and the heart fails to pump regularly. During a Malignant
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