Malignant Hyperthermia Research Paper

Malignant Hyperthermia is primarily thought to be an autosomal dominant genetic disorder that causes a hypermetabolic state after administration of volatile anesthetics. When a patient is under anesthesia, the muscles are usually relaxed, but when a patient is experiencing Malignant Hyperthermia crisis, certain IV anesthesia causes the opposite effect. Most inhaled anesthetics other than nitrous oxide, cause or trigger Malignant Hyperthermia. More specifically, the anesthetic agents: Halothane, Chloroform, and Succinylcholine. The genic condition of Malignant Hyperthermia only becomes apparent when a patient is exposed to certain anesthetics such as halothane, which causes muscle rigidity.

Malignant Hyperthermia is a life-threatening, genetic disorder that involves the skeletal muscles. It commonly occurs intraoperatively and postoperatively when inhalant agents such as halothane, enflurane, and isoflurane are used, as well as some muscle relaxants such as succinylcholine and curare. It

American Heart Association (AHA) estimates that nearly 700 Americans die each day of sudden cardiac arrest (MI), or 250,000 every year, as many as 50,000 lives could be saved each year if certain critical interventions were made. (Freeman , 50) A patient who receives early life support measures and defibrillation within one to five minutes of arrest is much more likely to live and to retain normal brain function. The brain is often at a serious risk for irreparable brain damage related to anoxia and many other co-morbidities that are associated with cardiac arrest (MI). When a perfusing cardiac rhythm returns after a heart attack, the most important objective is to preserve brain function. The AHA and the Advanced Life Support Task Force of

The evidence surrounding the topic of therapeutic hypothermia post cardiac arrest is one lathered in potentially advantageous benefits, as well as harmful side effects. Although this procedure has potentially lifesaving and neurologically preserving implications, it does come with various side effects which can be dangerous in general or if left untreated. This paper will first address the many benefits, some of which include prolongation of life, retention of neurological function. It will then shed light upon some of the subsequent risks and harmful effects that are associated with therapeutic hypothermia. Lastly the paper will discuss why or why not the overall benefits outweigh the aggravating factors. Thus, being a topic of much controversy

The nursing topic that I am going to base my final paper on is the use of hypothermia therapy following the successful resuscitation of adult patients. I want to further understand the positive or the negative outcomes for patients after we have using the hypothermia therapy protocol. hypothermia _1_.pdf This is one of the research studies that I plan on using in the research for my finial paper. The PICO question that I will be trying to answer in my research paper will be " In the resuscitated adult patient does the use of hypothermia therapy have a reduced mortality rate for adult patients after they have been discharged from the hospital?" By using the definition of PICOT from our book, the P in my research is resuscitated adult patients,

Malignant hypothermia has many symptoms including bleeding, dark brown urine, low blood pressure, and a rapid heartbeat. Most patients will have the high body temperature of 105-113 Fahrenheit, muscle rigidity and stiffness, muscle pain, and sweating profoundly. These symptoms occur within one hour of the anesthetic or can take up to 12 hours to show. Some complications of MH include amputation, death, kidney failure, abnormal bleeding/blood clotting, swelling of the feet and hands,

In the United States out-of-hospital cardiac arrest (OHCA) is a common occurrence among adults. In 2013, according to the American Heart Association (AHA), 359,400 individuals suffered from OHCA with an overall survival rate of 9.5% (AHA, 2014). Even with rapid chain-of-survival initiation, (i.e. immediate recognition of cardiac arrest, early cardiopulmonary resuscitation (CPR), early defibrillation, effective advanced life support, and post cardiac care) mortality following OHCA remains elevated (Lee & Cone, 2014). In the chain of survival, the post resuscitation period is thought to be the missing link. Therapeutic hypothermia (TH) is one such post resuscitative

Hypothermia is a common problem in surgical patients. Up to 70% of patients experience some degree of hypothermia that is undergoing anesthetic surgery. Complications include but are not limited to wound infections, myocardial ischemia, and greater oxygen demands. The formal definition of hypothermia is when the patient’s core body temperature drops below 36 degrees Celsius or 98.6 degrees Fahrenheit. Thus, the purpose of the paper is to synthesize what studies reveal about the current state of knowledge on the effects of pre-operative warming of patient’s postoperative temperatures. I will discuss consistencies and contradictions in the literature, and offer possible explanations for the inconsistencies.

If the disease is unmanaged, it causes several complications that can be fatal. One of those is hypertension, which, if not

Shock is a life threatening medical condition where there is very low amount of blood flow through the human body. There are many different types of shocks:

Hyperthermia is a healthier treatment because it is safer. While there are other cancer treatments, this one has less severe effects. Chemotherapy can cause heart problems, reduced lung capacity, kidney and urinary issues, numbness, bone and joint problems,

Dantrium is the trade name for a generic drug called dantrolene-sodium which is classified as a direct-acting skeletal muscle relaxant. This drug is available for use in both intravenous and capsule form, the following information if for the intravenous product

    Cancer is a disease in which cells multiply out of control and gradually build a mass of tissue called a tumor. There has been a large amount of research dedicated to the treatment and cure of cancer. Several types of treatments have been developed. The following are just some of the major examples of cancer therapy: surgery, chemotherapy, radiation therapy, biologic therapy, biorhythms, unconventional treatments, and hyperthermia. Each type of treatment is discussed in detail below.

The mid-latitude summer, mid-latitude winter, and high latitude data sets show evidence of some mixing. This was determined by observing how some deeper depths have a warmer temperature than depths that are not as deep. For example, on the high latitude temperature graph, the temperature is 0°C at a depth of 250 m. However, at deeper depths the temperature is warmer; one can assume that mixing took place.

Hyperthermia is a cancer treatment wherein the cancerous cells are killed by electromagnetic heating of malignant tumor tissue. This study is focused on the effect of using a 432 MHz antenna heating source for hyperthermia treatment of tissue. Temperatures of 42 °C to 46 °C are required to kill the cancer cells while the healthy tissue is unaffected. The Pennes Bio-Heat Equation is used to obtain a numerical solution of the tissue temperature profile. A 1-D analytical solution required to make quick calculation is derived and compared with the 2-D numerical solution solved by Finite Difference Method (FDM). Also, the effect of variable tissue properties in the tissue region of tumor and healthy tissue is determined and the effect of a large blood vessel is also determined.