Malignant Melanoma Research Paper

Melanoma is caused by over exposure to UV which can sometimes cause sunburn, it can be especially critical to those whom are inclined to the disease itself. The tumours derive in the pigment-producing melanocytes which are inside the basal layer of the

The largest organ of the human body is your skin. It is your body’s first line of defense against infections, injuries, heat, and sunlight. It also helps in controlling the temperature of your body and getting rid of the excess water and salt by sweating it out. Skin cancer is also known as cancer of the sun. Excessive amounts of ultra violet lights affect your skin in negative ways, possibly leading to Melanoma skin cancer. Melanoma is the most serious type of skin cancer there is and can often times be fatal (McClay).

There are three primary layers of the skin: the outer layer, the epidermis and the layer beneath, the dermis and the hypodermis. The epidermis is thin, tough and waterproof while protecting the body from outside bacteria invading the body. It also contains keratinocytes which are from the basal layer which is the deepest layer of the skin. The keratinocytes reach up to the epidermis, shed and new ones form again. The dermis is the second layer of the skin and is the thickest. It is made from fibrous and elastic tissues which are made from fibrillin, elastin and collagen to create the strength and flexibility. It also contains sweat and oil glands, nerve endings, blood vessels and hair follicles. Sweat glands help the body cool off during heat

Although there are several types of skin cancer, the most aggressive form is melanoma. This cancer of the skin involves mass replication of the pigment producing melanocyte cells, which are located in the epidermis, below the basal layer. There are several factors involved with the onset of melanoma including, exposure to ultraviolet rays, genetic predisposition, numerous nevi (moles), immunosuppression, and environmental exposure to carcinogens.

Basal Cell Carcinoma – Most common type of skin cancer it accounts for 80% of non-melanoma cancers. If left untreated it can affect skin, bone tissue, and cause death.

Everyone has some sort of mole or spot on there body. A speckled face can also turn into a dangerous cancer called melanoma. Melanoma accounts for relatively few cases of cancer and is highly treatable when caught early. You should always look into any suspicious moles or spots right away. Melanoma is a cancerous growth that occurs because of unrepaired DNA damage to skin cells. To determine whether to get expert advice, you can search for 5 common identifying factors, outlined by the National Cancer Institute as the ABC’s of

Melanoma is a malignant condition arising from melanocytes in the basal layer of the skin. Melanocytes are the cells that produce melanin, which gives skin its pigmentation and shields the deeper layers of skin from the damaging effects of ultraviolet radiation. When skin is exposed to ultraviolet radiation, melanocytes increase their production of melanin, which generates darker pigmentation of the skin. Ultraviolet radiation stimulates malignant changes within the melanocytes by mutating DNA, stimulating cutaneous growth factors, decreases immune defenses, and promotes species of melanin that cause DNA impairment and suppress apoptosis. The abnormalities caused by ultraviolet radiation in the melanocytes predispose it to

While researching in depth Ocular Melanoma, there has been a consistent theme persisting there is not enough research done to find a way to decrease metastasis percentage and increase survival rate. The current attempts at decreasing metastasis and increasing survival rate have stayed the same throughout the course of 4 decades. The current drug, LS2616, is being used to treat Ocular Melanoma patients, but it is used to late to feel the full impact of the drug. Research and Development laboratories are working on a faster-acting drug, but nothing has been tested on mice or released to the public. If new drugs could be created, the survival rate of Ocular Melanoma would increase drastically.

Many people think that is it possible to achieve a “healthy tan,” but this thought has been proven wrong. Overexpose to UV-A and UV-B rays from the sun lead to premature aging of the skin, as well as the possible formation of skin cancer, know as melanoma. An appearance of a tan is actually a stage of burning and damage to the skin. Although a tan may be desirable to many, the fact remains that more people need to be educated on the dangers of the sun’s harmful rays, and the possible health complications of overexposure.

Melanoma being the austere form of skin cancer which can be fatal in most cases. Mayo Clinic’s article on the diseases and conditions of melanoma gives good clarity as to what is actually occurring, and how it forms. The article states that what causes melanoma is unclear and hasn’t been discovered but what takes place is the melanocytes that generate melanin cells is agitated by unknown causes which results in the change in pigmentation of the skin or a change in a current mole already present on the skin. Strategies that can help you detect the symptoms of melanoma consist of the letters “A- E meaning A: asymmetrical shape regarding moles, B: irregular boarders, C: change in color, D: diameter, and E: evolving” (Mayo Clinic Staff 2016) Melanoma can appear not only on the skin but underneath a person’s nail, it can affect their eyesight and rarely their internal organs such as the mouth, urinary tract, and digestive tract called mucosal melanoma. These are noted to be hidden

In 2011, there were 1544 deaths in Australia that resulted from melanoma. It is the fourth most common cancer that is diagnosed in Australia. There is a 1 in 14 chance for men to be diagnosed with melanoma by the age of 85, while for women it is 1 in 24. As a result, the country with the highest incidence for melanoma has become Australia. Although, these fatal events could have been prevented with the use of sun safety and being conscious with the risks.

Central to the diagnoses of skin cancer is a full history and careful examination. Lesions that carry features suggesting malignant melanoma should be removed promptly. The deeper the lesion, the higher the risk for local and distant spread. Superficial spreading and nodular melanoma is the most common form of melanoma to the Caucasian population. It appears as a flat brown or black (dark) patch with a border that is irregular. Nodular formation signposts a vertical invasion and it is associated with a worse prognosis. It’s typical for nodular melanomas to bleed or ulcerate. Lentigo malignant is a premalignant lesion that is most common among older individuals and usually forms in the face. It looks like an irregular, flat brown lesion with

Even if a series of significant results is identified in this analysis, there exist several serious limitations. One of the most obvious limitations is displayed through Figure 1. Even if none of the years after 1989 happened to have statistically significant implication for the melanoma rates, there are still a lot of missing observations for years 1989 and 1994. If the number of industries reporting chemicals was equivalent for all years, we might have had a chance to derive even more significant results for 1989 and 1994.

Melanoma is the second most diagnosed cancer among young adults, ages 20-39 years (Bleyer & Barr, 2009). Risk factors for developing skin cancer are greatly influenced by behavior, such as failing to adequately protect oneself from ultraviolet radiation (UV) exposure from the sun (Gandini et al., 2005). Young adults have especially high rates of UV exposure (Coups, Manne, & Heckman, 2008). However, 50 to 85 percent of them fail to properly protect themselves from the sun (e.g., wear adequate sunscreen; Cokkinides, Weinstock, Lazovich, Ward, & Thun, 2009; Jones, Saraiya, Miyamoto, & Berkowitz, 2012). For these reasons, it is important to investigate psychosocial correlates of sun protection behavior in this population in order to help design effective interventions.

Going tanning to get that healthy glow is like leaving toast in the toaster for too long. Imagine leaving your toast in the toaster for six minutes and come back to see it being completely black and unappealing. If heat rays can do that to your slices of bread just imagine what those rays can do to your skin. That perfect glow means getting a shine on your melanin and giving your skin that bronze look. But, that melanin can lead to a much dangerous skin disease known as melanoma. Melanoma is a skin cancer that has taken over 9,000 lives in just 2014 alone.